ACACIA-HCM trial topline results - aficamten in nHCM. Incredibly proud and thankful to our patients and team for their commitment and hard work. This represents the first effective treatment for patients with nHCM. looking forward to seeing the full results.
#CardioTwitter
Danicamtiv enhanced cardiac myosin function in vitro and was generally well tolerated in #DCM. Echo findings suggest improved contractility, with strongest responses in #MYH7 and TTN cohorts jacc.org/doi/10.1016/j.jacc.…#JACC#cvDCM
RBM20 cardiomyopathy carries a more significant burden at a younger age, and an accelerated course compared to TTN cardiomyopathy
pmc.ncbi.nlm.nih.gov/article…#CardioTwitter
Limiting fluid intake may have no benefit for patients with #HeartFailure, according to findings from the FRESH-UP study presented during a Late-Breaking Clinical Trial session at #ACC25.
Check out the key findings ➡️ bit.ly/3DYGHEl
Cardiopulmonary exercise testing (CPET) has a unique role in the assessment of cardiopulmonary disease. @BrazileTiffany and colleagues review key CPET variables, protocols and clinical indications. eviden.cc/4aC6uOt
ALT A visual representation of cardiopulmonary exercise testing applications.
Heart failure with preserved ejection fraction is noted for symptoms of heart failure, LVEF of at least 50%, and cardiac or structural abnormalities. Treatment includes diuretics and SGLT2 inhibitors. Learn more: nej.md/4h41K6k
ALT A diagram of a pragmatic approach to the diagnosis of heart failure with preserved ejection fraction.
🔬New in @JACCJournals: HCM diagnosis criteria show unexpected demographic bias. Study of 50,000 hearts reveals current thresholds create 8:1 male-female ratio
Proposing demographic-adjusted thresholds to improve diagnosis🫀
authors.elsevier.com/a/1kPE5…@UCL_ICS@NHSBartsHealth
This is nice work on an important question in EP. I have an idea about a subgroup. Mandrola theory of de novo AFlutter. If it occurs in pt w prior heart surgery, CTI likely enough. If no prior surgery, CTI PVI better. #epeeps
LOE 👆= opinion. #EPeeps
Should we isolate the pulmonary veins in all patients with atrial flutter? Does PVI replace the need for cavitricuspid isthmus isolation? Provocative findings in systematic led by Daniel Gomes. Great collaboration @SergeBoveda , @DhirajGuptaBHRS , et al. #Afib#atrialfibrillation
As promised, here is a slew of content ...re the PLATO trial of ticagrelor vs clopidogrel in patients with ACS
This all occurred in 2009, early in my critical appraisal learning.
Revisiting PLATO controversy is super important--both clinically and epistemologically
🗝️ Collecting a detailed family history and pertinent clinical data for patients with cardiomyopathies is needed to guide potential use of genetic testing.
Read more key points on genetic testing for cardiomyopathies ➡️ bit.ly/4fho5vK#HeartFailure
2024 ACC Expert Consensus Decision Pathway on Strategies and Criteria for the Diagnosis and Management of Myocarditis: A Report of the American College of Cardiology Solution Set Oversight Committee | Journal of the American College of Cardiology jacc.org/doi/10.1016/j.jacc.…