CardioScience: ♥️ detección de arritmias cardiacas por monitoreo electrocardiografico continuo EL GRAN PASO PARA LA DISMINUCIÓN DE LA MORTALIDAD DEL INFARTO AGUDO en las unidades coronarias 💓💓

The Case of the Missing Dip: Glucocorticoid Rhythms, Vascular Clocks, and Blood Pressure Timing Read Prof. Isabel Goncalves' comment on the Cardiovascular Research article "Loss of circulating glucocorticoid rhythm disrupts the circadian transcriptome and vascular reactivity in the mouse renal artery", highlighting how the results offer a molecular framework for understanding non-dipping blood pressure patterns and may reveal rhythm-based therapeutic opportunities ow.ly/QlE450YwPU6 #CardioScience #TranslationalScience #CardiovascularResearch

Taming the Scar: How Timed ADAM17 Inhibition Improves Post-MI Healing Read Prof. Isabel Goncalves' comment on the Cardiovascular Research article "Temporal inhibition of ADAM17 in fibroblasts reduces stiffness and promotes vascularization following myocardial infarction", highlighting that this study identifies a pivotal role for ADAM17 in post-MI remodelling ow.ly/cfPh50YtxkJ @bellasgon #CardioScience #TranslationalScience

Grateful for the opportunity to contribute to the new scientific statement from the @escardio on metabolic dysfunction and cardiovascular disease. A great collaborative effort across ESC Basic Science Council and Working Groups. #CardioScience #ESC academic.oup.com/eurheartj/a…

@ionispharma announced that the FDA has accepted a supplemental NDA for olezarsen to treat severe hypertriglyceridemia (sHTG) and granted Priority Review. Target action date: June 30, 2026. ir.ionis.com/news-releases/n… #Hypertriglyceridemia #Triglycerides #FDAReview #CardioScience

New study shows deleting FHR1 reduces atherosclerosis, inflammation, and plaque formation in mice—revealing a novel immune-lipid axis in cardiovascular disease. #Atherosclerosis #CardioScience #Immunology #ComplementSystem #TranslationalResearch buff.ly/QEVu3ct

🚨 New insights on LV mass and mortality! A large multicentre study of >300,000 echocardiograms reveals that our current thresholds for identifying LV hypertrophy may miss many at-risk patients. 🔍 Key findings: • Mortality risk increases at much lower LVMi values than traditional ASE cut-offs.  ➡️ ≥88 g/m² in men  ➡️ ≥82 g/m² in women • Over 50% of patients fall into these newly defined risk categories. • Results validated in an independent US cohort with no major comorbidities. • Identifying LVH earlier could transform how we approach risk stratification, follow-up, and therapeutic timing. 💡 A call to rethink what we consider “normal” LV mass. #Cardiology #Echocardiography #LeftVentricle #LVH #HeartFailure #RiskStratification #CMR #EchoResearch #JAHA #CardioScience ahajournals.org/doi/suppl/10…

💡All articles in Reviews in Cardiovascular Medicine (ISSN: 2153-8174)--Volume 26, Issue 12--, are now freely available to access, read and download: imrpress.com/journal/RCM/26/… The editorial team has selected some featured articles for you—inviting all readers to explore and share! Featured Article: 1️⃣ Spontaneous Coronary Artery Dissection in Women: imrpress.com/journal/RCM/26/… 2️⃣ The Beneficial Effects of Glucagon-Like Peptide-1 Agonists on Blood Pressure: A Comprehensive Review: imrpress.com/journal/RCM/26/… 3️⃣ A Comprehensive Review of the Management of Light-Chain (AL) and Transthyretin (ATTR) Cardiac Amyloidosis: imrpress.com/journal/RCM/26/… 4️⃣ Endothelin as a Treatment Target in Cardiovascular Diseases: A Recent Step Forward: imrpress.com/journal/RCM/26/… Share your research with us! Submit your work: imr.propub.com RCM welcomes review papers, research articles and other types of research in both cardiovascular medicine and cardiovascular disease. 📖 Click here for author guidelines: imrpress.com/journal/RCM/pag… #CardiovascularMedicine #HeartHealth #OpenAccessJournal #InterdisciplinaryResearch #RCM #CardioScience #ClinicalCardiology

CardioScience: Detección de síndrome de Taqui-Bradicardia o del seno enfermo por medio de curva oximetrica asociado a hipertensión arterial sistémica con severo descontrol ♥️

CardioScience: Morfología electrocardiografica de los ritmos cardiacos sinusal, auricular, nodal y ventricular♥️

🌟 New insights into cardiovascular proteomics from UK Biobank! A large-scale analysis of nine key circulating proteins — including ACE2, NT-proBNP, BNP, BAG3, NOTCH1, ACTA2 and more — reveals how genetics, lifestyle, medications and disease interact to shape cardiovascular risk. 🔍 Key findings: • Strong associations between protein levels and age, sex, ancestry, lifestyle (alcohol, smoking). • Genetic modifiers identified at GCKR, APOE and SERPINA1, influencing multiple proteins. • ACE2 emerges as particularly important — higher circulating levels were linked with hypertension and type-2 diabetes, yet Mendelian randomisation suggests a protective causal role. • NT-proBNP and BNP correlated with structural heart traits, arrhythmias, and future diagnoses of heart failure and atrial fibrillation, reinforcing their prognostic value. • Individuals carrying pathogenic variants for HCM or DCM showed elevated NT-proBNP, highlighting early biomarker potential. 💡 Why this matters This work enhances our understanding of the biological pathways connecting proteomics, genetics, and cardiovascular disease — and points toward future opportunities for precision medicine, risk stratification, and biomarker-guided therapies. #Cardiology #Proteomics #GenomicMedicine #UKBiobank #CardiovascularResearch #PrecisionMedicine #HeartFailure #Hypertension #Biomarkers #NTproBNP #ACE2 #Genetics #AHA #ResearchUpdate #CardioScience doi.org/10.1161/CIRCGEN.124.…

➰Why Hydralazine Isosorbide Dinitrate Is Specially Effective in Black Patients with HFrEF? 🌀Because this combo restores a failing nitric-oxide (NO) pathway — a pathway shown to be biologically less active in many Black patients with heart failure. 🌀The result? Better vasodilation, improved hemodynamics, and dramatically reduced mortality. 🤹How the Combo Works (Beautiful Synergy):- •🌀Isosorbide Dinitrate → Releases NO → Venodilation ↓ Preload •🌀Hydralazine → Arterial dilation prevents NO breakdown → ↓ Afterload •🌀Together → Enhanced NO signaling → More stroke volume, less congestion, better survival 🤹Landmark A-HeFT Trial (NEJM): •🌀43% ↓ all-cause mortality •🌀33% ↓ HF hospitalizations •🌀Significant improvement in symptoms & quality of life 🌀These benefits were uniquely pronounced in Black patients. 🤹When We Use This Combo: •🌀NYHA III–IV HFrEF in Black patients already on optimal therapy (ACEI/ARB/ARNI β-blocker MRA). •🌀Patients who cannot take ACEI/ARB/ARNI due to renal issues or hyperkalemia. 🤹Clinical Pearl: 🌀This is the only heart-failure therapy with race-specific, trial-proven survival advantage — by correcting the NO-deficiency phenotype. #HeartFailure #Hydralazine #IsosorbideDinitrate #AHeFT #CardioScience #EvidenceBasedMedicine #HFManagement #KriMeeraPharma

David A. Kass Director, Johns Hopkins Institute of Cardioscience, USA Meet the leaders at the 3rd Olympiad in CV Medicine April 30-May 3, 2026 Kalamata & Olympia, Greece Chairs: @mkontari & @kdrosato Registration-Abstracts submission: cvolympiad.com

💡All articles in Reviews in Cardiovascular Medicine（ISSN: 2153-8174)--Volume 26, Issue 10--, are now freely available to access, read and download: imrpress.com/journal/RCM/26/… The editorial team has selected some featured articles for you—inviting all readers to explore and share! Featured Article: 1️⃣ Traditional and Virtual Cardiac Rehabilitation: Understanding the Changing Landscape of Cardiac Rehabilitation and the Implications on Patient Outcomes: imrpress.com/journal/RCM/26/… 2️⃣ A New Era in the Management of Hypertrophic Cardiomyopathy: imrpress.com/journal/RCM/26/… 3️⃣ Transcatheter Management of Acute Mechanical Complications Post-Myocardial Infarction: imrpress.com/journal/RCM/26/… 4️⃣ Vitamin D and Cardiovascular Disease: The “Good”, the “Bad”, and the “Unknown”: imrpress.com/journal/RCM/26/… Share your research with us! Submit your work: imr.propub.com RCM welcomes review papers, research articles and other types of research in both cardiovascular medicine and cardiovascular disease. 📖 Click here for author guidelines: imrpress.com/journal/RCM/ins… #CardiovascularMedicine #HeartHealth #OpenAccessJournal #InterdisciplinaryResearch #RCM #CardioScience #ClinicalCardiology

🎭Nitric oxide (NO) is a crucial signaling molecule involved in vasodilation, immune modulation, neurotransmission, and mitochondrial function. As we age, NO production naturally declines — contributing to hypertension, atherosclerosis, cognitive decline, and impaired immune response. 🤹Drugs like PDE-5 inhibitors (e.g., Sildenafil, Tadalafil) boost NO signaling by blocking its breakdown, increasing cyclic GMP, and enhancing blood flow. 🫆But why are they mainly used for erectile dysfunction? 🤹Reason: •🌀The penis is a highly vascular organ, and erections are primarily driven by rapid NO-mediated vasodilation. •🌀It’s a clear, measurable, and quick therapeutic response, making ED a suitable FDA-approved indication. •🌀Regulatory pathways and market incentives prioritized sexual health over broader, more complex NO-related diseases. 🎭However, current research is expanding: •🌀PDE-5 inhibitors show promise in pulmonary hypertension, cardiac remodeling, Raynaud’s phenomenon, and even neurodegenerative disorders. •🌀L-arginine, beetroot extract, citrulline, and exercise are non-pharmacologic strategies to raise NO and are often used in aging, performance, and cardioprotection. 🤹Bottom line: Sexual health was just the first stop. NO-based therapies have much broader potential — and research is catching up. #CardioScience #NitricOxide #KriMeeraPharma

🔬 New study: Systemic inflammation modulates how Lipoprotein(a) drives coronary stenosis in chronic coronary disease — suggesting inflammation isn’t just bystander but a key amplifier. 🔗 ow.ly/Q8B650Xairl #Lp(a) #Inflammation #CVDPrevention #CardioScience

LDL-C enters the artery wall when the endothelium is stressed/dysfunctional and becomes trapped by intimal proteoglycans. That sub-endothelial retention is a key initiating step in atherogenesis. #LDL #Atherosclerosis #CardioScience #HeartHealth

High LDL-C drives plaque buildup inside arteries. Clinical trials show that every 39 mg/dL (1 mmol/L) LDL-C reduction lowers major cardiovascular events by ~20–25%. Lower LDL → Less plaque → Fewer heart attacks. #CardioScience #Prevention

🌍 #Cardiology #CardiacSurgery #HeartFailure #InterventionalCardiology #Cardiometabolic #PreventiveCardiology #GlobalCardio #HeartTeam #CTsurgery #CardioTwitter #SurgTwitter #WomenInCardiology #WomenInSurgery #ESC #ACC #AHA #CCS #CSCS #STS #AATS #EACTS #HFSA #HFA #EASD #ADA #ISH #TCT #PCR #SCAI #JACC #Circulation #EHJ #NEJM #Lancet #CVResearch #AcademicSurgery #CardioScience #MedTwitter #WorldHeartDay #VascularSurgery #DiabetesCardiology #CardioOncology #PrecisionCardiology 👥 @escardio @ACCinTouch @American_Heart @CanCardioSoc @CSCSHeart @AATSMeetings @STS_CTsurgery @EACTS @HFSA @HFNewsdesk @EASDnews @AmDiabetesAssn @SCAI @PCRonline @JACCJournals @CircAHA @EuroHeartJourn @TheLancet @NEJM @EricTopol @hmkyale @drjohnm @drjohnmandrola @dr_bhatt_md @maraantonoff @BiykemBozkurtMD @ProfEugeneBraunwald @DrRoxanaMehr @DrMarthaGulati @drsanjaygupta @ProfAnandPandit @ProfCleland @ProfStefanAnker @ProfFaiezZannad @CTSnetorg @BrighamCardiac @StanfordCVMed @ClevelandClinic @MayoClinicCV @MountSinaiHeart @TorontoMed @uoftmedicine

📢 The latest contribution from Dr. Massimo Mapelli(@MapelliMassimo ) and his team at IRCCS is now featured in RCM! Welcome to read this article 👉: imrpress.com/journal/RCM/26/… Article Highlights 💡 How do novel heart failure (HF) therapies impact functional capacity? This article synthesizes evidence on CPET metrics—VO₂ peak, VE/VCO₂ slope, OUES—across conventional drugs and emerging agents like ARNIs, SGLT2i, vericiguat, GLP-1 RAs, and finerenone. ✒️ Author: Nikita Baracchini, Teresa Maria Capovilla, Simona Costantino, Fiorella Puttini, Elisabetta Salvioni, Irene Mattavelli, Massimo Valenti, Emilia d'Elia, Elena Bertarelli, Piergiuseppe Agostoni, Gianfranco Sinagra, Massimo Mapelli 🏪 Affiliation: University of Trieste @UniTrieste; IRCCS; University of Milan; ASST Papa Giovanni XXIII Citation format: Nikita Baracchini, Teresa Maria Capovilla, Simona Costantino, Fiorella Puttini, Elisabetta Salvioni, Irene Mattavelli, Massimo Valenti, Emilia d'Elia, Elena Bertarelli, Piergiuseppe Agostoni, Gianfranco Sinagra, Massimo Mapelli. New Fuels for a Failing Engine: The Impact of Novel Heart Failure Drugs on Functional Capacity. Rev. Cardiovasc. Med. 2025, 26(9), 41919. doi.org/10.31083/RCM41919 📖 Don’t miss this citable reference for your future research! 👉Welcome to submit your work: imr.propub.com/ #HeartFailure #Cardiology #ExerciseCapacity #CPET #SGLT2i #ARNI #Vericiguat #MedicalResearch #RCMJournal #CardioScience #RCMPaper