Playing with #singlemolecules, bending light, and algorithms to see really small things. Led by Matthew Lew, Associate Professor @WashUESE @WashUengineers
Joined October 2015
- Tweets 124
- Following 146
- Followers 329
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32 Photos and videos
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11 Mar 2025
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Lew Lab @ WashU retweeted
Apr 26
Shooting oneself in the foot?
Nope.
Shooting oneself in the prefrontal cortex.
U.S. President Donald Trump has fired all 24 members of the National Science Board, the body that oversees the National Science Foundation. Many science advocates see it as the latest step by his administration to erode—some would say destroy—the independence of the 76-year-old research agency. scim.ag/4eGM0YS
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Lew Lab @ WashU retweeted
For this #SpotlightSunday, view this Spotlight by Matthew D. Lew of #OPG_JOSA_A: Surface orientation ambiguity for single molecules at dielectric interfaces bit.ly/4kh9vJ0 #OrientationImaging #RefractiveIndex @UTArlington
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25 Nov 2025
Very happy to share this news of my election to become an #OpticaFellow. I'm grateful to my many students and mentors over the years. Happy Thanksgiving!
25 Nov 2025
Meet the new #OpticaFellows!
The Optica Board of Directors is pleased to announce that 121 members from 23 countries have been elected as Fellows for their outstanding contributions and service to Optica and the community.
Find the full class: bit.ly/4rgXHtn
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Lew Lab @ WashU retweeted
4 Nov 2025
How do discoveries in the lab become lifesaving treatments?
This updated infographic provides a big-picture view of the R&D pipeline, illustrating the public-private sector continuum from discovery to delivery. It visualizes just how much innovation depends on collaboration among multiple sectors and stages of research.
Use this resource in your outreach to show how progress slows when any segment is underfunded or otherwise weakened.
#FundScience #MedicalInnovation #HealthResearch
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14 Apr 2025
"A new polarized dual-view inverted selective-plane illumination microscope (pol-diSPIM), coupled with engineering insights provided by its imaging model, offers an exciting way forward." My commentary is online in PNAS pnas.org/doi/10.1073/pnas.25…
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11 Apr 2025
Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates: nature.com/articles/s41467-0…
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Lew Lab @ WashU retweeted
20 Mar 2025
Experiments confirm the prediction that fluid-like biomolecular condensates are defined by spatially inhomogeneous organization of the underlying molecules.
nature.com/articles/s41567-0…
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21 Mar 2025
14 Mar 2025
A team of #WashUEngineers researchers has developed a new method to study biomolecular condensates — tiny, shifting blobs in our cells that help organize important molecules.
Learn more. {link}
engineering.washu.edu/news/2…
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Lew Lab @ WashU retweeted
20 Mar 2025
Matthew Lew of @WashUESE & grad student Yiyang Chen developed a new method to improve precision in molecular imaging. Their technique boosts accuracy, with potential to transform studies in protein interactions & more.
#WashUEngineers
ow.ly/jBBq50VlF0E
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Lew Lab @ WashU retweeted
This semesters Biophysical Evening seminar will be given by Matthew Lew, Professor in Electrical & Systems Engineering at WashU
"Single-Molecule Orientation-Localization Microscopy: New Challenges and Biophysical Insights"
Thurs, March 20th 4-5 PM, Connor Auditorium
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Lew Lab @ WashU retweeted
7 Oct 2024
Out today from the Lee lab @SteveTheChemist In the POLCAM paper, they make polarization cameras compatible with single-molecule detection for instant molecular orientation microscopy. nature.com/articles/s41592-0…
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14 Aug 2024
News coverage of our JPC article pubs.acs.org/doi/10.1021/acs… "Wobbly molecules get a closer look" engineering.wustl.edu/news/2… via @WashUengineers @shawncballard
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18 Jul 2024
We made the cover! Check out Weiyan's work exploring the "Fundamental Limits in Measuring the Anisotropic #RotationalDiffusion of #SingleMolecules" in @JPhysChem doi.org/10.1021/acs.jpca.4c0… @WashUESE @WashUengineers
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12 Jun 2024
Brian's study on using the #binding #orientations of Nile blue to decipher the architectures of growing, decaying, and remodeling #amyloid #fibrils is now online in @NanoLetters !
#singlemolecule @WashUESE @WashUengineers doi.org/10.1021/acs.nanolett…
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6 May 2024
Congratulations Dr. O! @wuimgsci_stuco @WashUengineers
Congratulations to Joseph O’Sullivan, the Samuel C. Sachs Professor of Electrical Engineering! He was among 12 faculty and staff awarded at the 25th Annual Outstanding Faculty and Staff Awards.
Read more here: ow.ly/Gqhu50Rr7g2
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2 May 2024
Our work with @JaiRudra4 is online here pubs.acs.org/doi/10.1021/acs…
1 May 2024
Matthew Lew & Jai Rudra's teamwork brings forth a new imaging method. Their technique highlights interlocking peptides, crucial in identifying toxic strains in Alzheimer’s.
#WashUEngineers #Imaging @WashUBME @WashUESE
ow.ly/b5pw50RsY4A
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25 Apr 2024
Resharing our recent cover article on imaging the architecture of peptide assemblies using #singlemolecule #orientation imaging!
From the cover of our new issue: Researchers led by @Lew_Lab & @WashUengineers show the nanostructure of β-Sheet #peptide self-assemblies using Nile red (NR) & single-molecule orientation–localization microscopy (SMOLM).
Read more 👉 go.acs.org/8Ms
ALT TOC image from the article
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25 Mar 2024
Excited to share Weiyan's work with @JaiRudra4 on using #singlemolecule orientation-localization microscopy to visualize these helical assemblies! @WashUESE @WashUengineers doi.org/10.1021/acsnano.3c11…
20 Mar 2024
Thanks to a wonderful collaboration with Matt Lew @Lew_Lab helping us visualize polymorphisms in amyloid-inspired peptide assemblies using Single Molecule Orientation-Localization Microscopy. pubs.acs.org/doi/10.1021/acs…
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24 Mar 2024
Happy to see @Tingting_Wu_'s review chapter on 6D dipole-spread function engineering now online doi.org/10.1007/978-3-031-39… @WashUengineers @WashUESE
A big thanks to @JinyangLiang for putting such a great volume together! doi.org/10.1007/978-3-031-39…
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