I study floppy proteins and teach students who are incarcerated | mattryanking.com

Joined June 2019
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Floppy protein phase separates to make microtubules grow off each other super efficiently. (Shameless self promotion 🙃) nature.com/articles/s41467-0…

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Matthew Ryan King retweeted
Congratulations to @DanaFarber's Cigall Kadoch, PhD, (@CKadoch) who was named as the Laureate of the Blavatnik National Awards for Young Scientists today. The prestigious award from @BlavatnikAwards and @NYASciences (cont) ms.spr.ly/l/6014mOVe0
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Matthew Ryan King retweeted
Congratulations to Avnika Pant on receiving a scholarship & invitation to attend the @MBLScience Physiology program this summer! This selective and intensive program is one of the oldest continually running biology courses. Avnika is a doctoral student with @PappulabWashU.
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🔥🔥How does the LINE-1 retrotransposon jump around in the human genome? Super excited to present my postdoctoral work answering this published today @Nature together with twitterless Kathy Collins's lab and @NogalesLab @UCBerkeley nature.com/articles/s41586-0… A 🧵
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Congrats to @sophiembtravis and team from @RuiZhangWUSTL and @LabPetry on the augmin structure! Also congrats to @PfefferCryoLab and @lchangpurduebio for their structural work!
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20 Jul 2022
Have you wondered how a decades-old oocyte can give rise to a new embryo while other cells in the body age? Our study @Nature, spearheaded by @AidaRoNu, uncovers the mechanism that allows early #oocytes to maintain ROS-free #mitochondria nature.com/articles/s41586-0…🧵
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Happy to present a new preprint from @MarileenD’s lab, in which we ask if a microtubule plus-end tracking comet is held together by interactions that also drive phase separation. The answer is not a clear ‘yes’ or ‘no’, so here goes the 🧵1/10
Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus ends biorxiv.org/cgi/content/shor…
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Matthew Ryan King retweeted
At some point you have to admit that doing things ironically can have very straightforward consequences. #FakeAccountsClub @laurenoyler
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Why am I "the only person who can see the true essence of this book?" Any thoughts @laurenoyler?
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Matthew Ryan King retweeted
29 Jan 2021
Beautiful work officially out by @SagarSetru, Bernardo deGouveia, Josh @shaevitz and Howard Stone - a tri-departmental @Princeton collaboration. What do drops on spiderwebs and protein droplets on microtubules have in common? #PhaseSeparation on Cellular Surfaces
A hydrodynamic instability drives protein droplet formation on microtubules to nucleate branches go.nature.com/39oh79J
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My kitties - Jenny and Emmy - couldn’t be prouder of their namesakes’ - Jennifer @doudna_lab and Emmanuelle #NobelPrize #CRISPR
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Jenny and Emmy are great collaborators
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Frogs rule!
Xenobots are programmable organisms made from the cells of frog embryos -- golems dreamed in silicon and then written into flesh. Should bioethicists be concerned? nyti.ms/2wcjDyY
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Matthew Ryan King retweeted
Once again: DO NOT TRACK THE NUMBER OF CASES. THIS IS SUPPOSED TO INCREASE AS TESTING COMES ONLINE. Instead, track the number of deaths per day. If the "doubling time" of these slows to more than 3 days, we're starting to bend the curve. thread: x.com/SamWangPhD/status/1241…

Bookmark this. When the doubling time of deaths* gets above 3 days, we will have begun to get past the runaway period of the pandemic. Note the current doubling times for China (35 days) & South Korea (12 days). *not cases, which can be underdiagnosed ourworldindata.org/coronavir…
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As promised, here is our first glimpse of the #COVID19 spike protein (aka the demogorgon) in action, courtesy of @foldingathome . More to come!
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Non-spherical coacervates are cool! I was wondering when this would be coming out. Congrats @luiree and Kasper!
PNPase mediated UDP Polymerization leads to non-isotropic Poly(U) * Spermine Coacervate Growth. High phosphate levels drive Poly(U) Depolymerization & Coacervate Dissolution. By @luiree & @MarileenD. Now in Langmuir: pubs.acs.org/doi/abs/10.1021…
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Matthew Ryan King retweeted
In a paper just published Rohit Pappu’s and my lab show that the number of stickers and their patterning determine LLPS of prion-like LCDs. Our findings lead to a numerical model that enables the prediction of full binodals from the sequence. science.sciencemag.org/conte… (1/15)
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Matthew Ryan King retweeted
10 Feb 2020
Come explore the Physics of Life. A summer school for advanced undergraduates. We have space for 24 students, with all local expenses covered and no tuition or fees. biophysics.princeton.edu/edu…

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