The NCI-funded Pancreatic Cancer Stromal Reprogramming Consortium (PSRC) is focused on improved understanding of the stroma & its interactions with cancer cells
Joined February 2019
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33 Photos and videos
PDAC Stromal Reprogramming Consortium retweeted
25 Jun 2023
Spatial determination and prognostic impact of the fibroblast transcriptome in #PancreaticCancer
elifesciences.org/articles/8…
Tumor proximity determines state:
“Tumor proximal” - enriched in myCAFs, wnt ligands
“Tumor distant” - enriched in iCAFs, complement, wnt inhibitory signals
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PDAC Stromal Reprogramming Consortium retweeted
22 Jun 2023
#ICYMI from the June issue—
In the Spotlight: #Pancreatic neoplasms are frighteningly common: A role for immune surveillance?
By Megan T. Hoffman and Stephanie K. Dougan.
bit.ly/4410ScI
@DanaFarber @DanaFarberNews @harvardmed
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PDAC Stromal Reprogramming Consortium retweeted
20 Jun 2023
Out in @NatureComms from the @hopkinskimmel team:
A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable #PancreaticCancer
@DrLizJaffee
nature.com/articles/s41467-0…
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The pancreatic microenvironment may contribute to cancer onset and spread, according to research published in @CD_AACR and presented at #AACRras23. Learn more on the #AACRBlog: bit.ly/3JnsvEp @umichmedicine
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PDAC Stromal Reprogramming Consortium retweeted
13 Jun 2023
From @Inserm @RemyNicolle et al in @NatureComms
Pacpaint: a histology-based deep learning model uncovers the extensive intratumor molecular heterogeneity of #PancreaticCancer
nature.com/articles/s41467-0…
~40% of RNA defined “classical” cases harbor “basal-like” component on #AI
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PDAC Stromal Reprogramming Consortium retweeted
6 Jun 2023
📢📢Spreading the word!!! Our Center, Henry Ford Pancreatic Cancer Center, is hiring a Grants manager!! If you are or know of someone who might be interested, please reach out!!!
henryford.referrals.selectmi…
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PDAC Stromal Reprogramming Consortium retweeted
9 Jun 2023
Featuring the opus that was @_sunnydae9's wide-ranging and outstanding dissertation work in #cancercachexia and #PancreaticCancer. Want to drive this project now? We are hiring! @OHSUKnight 🌉🛶🚠🚵♂️🗻🌊🧪🫂
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PDAC Stromal Reprogramming Consortium retweeted
7 Jun 2023
Teaser #PREOPANC2 design & accrual: Total #Neoadjuvant #FOLFIRINOX in resectable borderline resect #PancreaticCancer vs “winning arm” #PREOPANC trial #EAHPBA2023: accrual faster than planned ✅, final survival outcome expected in Sept 2023 ✅
@EmmelieDekker @BasGrootKoerkam @DPCG_official @DeltaplanA #alvleesklierkanker
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PDAC Stromal Reprogramming Consortium retweeted
8 Jun 2023
From the June issue—
Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Pre-Neoplastic #Pancreatic Lesions, by @Pasca_Lab, @timofran1 et al.
bit.ly/3P3wXf8
@UMICHpancreas @UMRogelCancer @UMichSurgery #PanIN #PancreaticCancer
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Submit an abstract by July 13 for the AACR Special Conference on Pancreatic Cancer (Sept 27-30, Boston), chaired by Christine A. Iacobuzio-Donahue, Anirban Maitra, Rosalie C. Sears, and Jen Jen Yeh.
bit.ly/3qDYFos
#AACRpan23 @ciacobu @Aiims1742 @SearsRosie @YehlabUNC
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PDAC Stromal Reprogramming Consortium retweeted
9 Jun 2023
Hey Mom, I'm on the radio! This was a fun experience. Thanks to @KellyCutrara the opportunity to raise awareness for #PancreaticCancer and discuss our new study! cc: @UMRogelCancer, @UMICHpancreas, @UMPhysiology, @PanCAN
pdst.fm/e/chtbl.com/track/74…
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10 Jun 2023
Letters of Intent for @CDMRP #PancreaticCancer Research Program are due in one month.
@PanCAN @arosenzweig19
cdmrp.health.mil/funding/pca…
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PDAC Stromal Reprogramming Consortium retweeted
8 Jun 2023
The Visium spatial transcriptomics data of human and murine IPMN samples from our @CD_AACR paper is available at GEO for download at:
ncbi.nlm.nih.gov/geo/query/a…
Hopefully will be useful to the #PancreaticCancer research community.
aacrjournals.org/cancerdisco…
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PDAC Stromal Reprogramming Consortium retweeted
7 Jun 2023
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PDAC Stromal Reprogramming Consortium retweeted
8 Jun 2023
So happy to have our study now out in @CD_AACR!! We used #SpatialTranscriptomics and COMET imaging to spatially profile IPMN lesions of the #pancreas and identified NKX6-2 as a previously unknown transcription factor driving indolent gastric differentiation.
7 Jun 2023
Now online in @CD_AACR: #SpatialTranscriptomics of Intraductal Papillary Mucinous Neoplasms (#IPMN) of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential @Marta_Sans_ @Aiims1742 @MDAndersonNews doi.org/10.1158/2159-8290.CD…
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PDAC Stromal Reprogramming Consortium retweeted
7 Jun 2023
Now online in @CD_AACR: #SpatialTranscriptomics of Intraductal Papillary Mucinous Neoplasms (#IPMN) of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential @Marta_Sans_ @Aiims1742 @MDAndersonNews doi.org/10.1158/2159-8290.CD…
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Submit an abstract by July 13 for the AACR Special Conference on Pancreatic Cancer (Sept 27-30, Boston), chaired by Christine A. Iacobuzio-Donahue, Anirban Maitra, Rosalie C. Sears, and Jen Jen Yeh.
bit.ly/3WReKmK
#AACRpan23 @ciacobu @Aiims1742 @SearsRosie @YehlabUNC
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Fantastic keynote by @YatrikShahLab at @PacmenC consortium meeting on hypoxia, lipids and gases in cancer.
Thank you @Pasca_Lab @LyssiotisLab @timofran1 for inviting Dr. Shah for this meeting.
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PDAC Stromal Reprogramming Consortium retweeted
7 Jun 2023
Excited to present our #PancreaticCancer stromal subtyping work at the @PacmenC meeting today in Ann Arbor Michigan with @YehlabUNC @itslaurapeng @isteaus! Had a lovely dinner last night with other U01 sites at @zingermans roadhouse. Big thanks to the organizers
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PDAC Stromal Reprogramming Consortium retweeted
6 Jun 2023
🚨Our📜officially out in June issue of Cancer Discovery @CD_AACR @AACR! Thank you #DattaLab members esp @anna_bianchi22, mentor @NbmerchantMD, collaborators @BenStanger01 @EnedaToska @GabrilovichLab, sponsor @DrSDNimer & funders @PanCAN #PardeeFdn @AcademicSurgery @AmCollSurgeons
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