The mission of The PolG Foundation is to support and accelerate research to find effective treatments and a cure for PolG-related mitochondrial disorders.
Excellent Bologna workshop on DNA polymerase gamma diseases, organized and facilitated by the new vibrant @PolGFoundation. Action plans, brainstorms. A stimulating global effort to make a difference for the devastating disease group. #mitochondrialdisease#ResearchBringsHope
The @PolGFoundation 2023 research call is open. The Foundation seeks to fund research projects of up to $250.000 p/y (max 5 year research projects) that will have direct impact on drug discovery and clinical development of PolG therapeutics. Full details: polgfoundation.org/call-for-…
ALT The image has a black background with large capital letters P, O and L in white and a large capital letter G in green. This is the POLG Foundation logo.
The mission of The PolG Foundation is to support and accelerate research to find effective treatments and a cure for PolG mitochondrial disorders.
To advance this mission, we are announcing our first Call for Proposals.
polgfoundation.org#polg#mitochondrialdisease
The @PolGFoundation 2023 research call is open. The Foundation seeks to fund research projects of up to $250.000 p/y (max 5 year research projects) that will have direct impact on drug discovery and clinical development of PolG therapeutics. Full details: polgfoundation.org/call-for-…
ALT The image has a black background with large capital letters P, O and L in white and a large capital letter G in green. This is the POLG Foundation logo.
Can we just take a moment to appreciate how crazy cool this is?
Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood
cell.com/cell-metabolism/ful…
Hello from The PolG Foundation!
Our story starts with the journey of one family and, more particularly, one young man, Frederik. Inspired by Frederik's example of sheer determination, they set out to transform hardship into deep resolve and find a cure for a devastating disease.
The disease comes from a mutation in POLG and POLG2 genes. These mutations impair efficient replication of the mitochondria DNA, causing symptoms that can start from early childhood to adulthood. Symptoms often include ophthalmoplegia, muscle weakness, epilepsy and liver failure.
We already have a few ongoing research projects.
Mouse model 1, Generating and investigating in vivo PolG mouse models to unravel the mechanistic pathogenesis of PolG disorders.
Mouse Model 2, Development and preclinical validation in mice of gene therapy treatment.