Brain Cancer Care Partner, #BTSM | Solution Architecture, Oncology, Genomics | Chaotic neutral tweets are mine and don't represent my employer. 🇺🇲🇮🇱
Joined October 2014
- Tweets 8,392
- Following 1,519
- Followers 2,231
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377 Photos and videos
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26 Oct 2024
One day the people of Iran, Israel, and Lebanon will dance together. May that day come sooner than later.
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Thank you, @mirandalevycopy, for sharing your interview with Shira Shapira. Many of us knew of Aner’s bravery in defending innocent lives at the @novafestival, but hearing his story through his mom brings the weight of it into focus.
October 7, and the wave of hatred that followed worldwide, is a stain on our shared humanity.
May Aner’s memory, and the memory of all those lost to this evil, be a blessing (BDE) to their families, their friends, and all of us who carry them forward.
Jun 13
Here's my interview in @MailOnline with Shira Shapira, the mother of Aner, who was killed on #October7 after @novafestival, but not before saving 10 lives. Going in print in @YouMagazine tomorrow. I'd love people to see this, so please retweet @nicolelampert @HeidiBachram @HenMazzig @JoosyJew @joshxhowie @MrsGarch #novaexhibition
dailymail.com/lifestyle/arti…
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Jun 10
New collaborative paper on IDH-mutant glioma with Tirosh, Suva, Lavarone, and Lasorella labs. They show how acquired genetic alterations converge with cell state changes and poor treatment responses.
Congrats to @Kevin_C_Johnson, @AvishaySpitzer, @M_Nomura, @MarioSuva, @TiroshLab, @RoelVerhaak et al.
Nature research paper: Acquired genetic and cell-state changes in IDH-mutant glioma progression
go.nature.com/4fJnCXp
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Jun 11
Here’s a great thread by @AvishaySpitzer about the recently published IDH-mutant paper. It is well worth reading, especially for those interested in brain cancer evolution.
x.com/avishayspitzer/status/…
1/8 Thrilled to share that our new paper is officially out in @Nature today!
nature.com/articles/s41586-0…
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Guy Lipof - גיא retweeted
The @gliomaregistry is headed to the 2026 Brain Tumor Epidemiology Consortium Annual Meeting in London this week!
Excited to present preliminary findings on knowledge and use of IDH inhibitors in a real-world sample of glioma patients. Huge thanks to #BTEC for this opportunity.
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Dear @replloyddoggett, I’m proud to join @NBTSTweets and brain tumor advocates across the country in urging Congress to support stronger brain tumor research funding and patient-focused policies.
Please see my below post to senators @JohnCornyn and @SenTedCruz . The need is urgent. Thank you!
#Head2Hill #GoGrayinMay
May is Brain Tumor Awareness Month.
Thank you @JohnCornyn and @SenTedCruz for your continued support.
Now let’s move the BRAIN Act (H.R.2767 / S.1330) forward. It’s been sitting in committee for a year.
Increased NIH/NCI funding is critical to drive new treatments and improve quality of life for those facing this devastating disease.
braintumor.quorum.us/campaig…
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May is Brain Tumor Awareness Month.
Thank you @JohnCornyn and @SenTedCruz for your continued support.
Now let’s move the BRAIN Act (H.R.2767 / S.1330) forward. It’s been sitting in committee for a year.
Increased NIH/NCI funding is critical to drive new treatments and improve quality of life for those facing this devastating disease.
braintumor.quorum.us/campaig…
9 Sep 2025
Hi @JohnCornyn and @SenTedCruz, I'm joining @NBTStweets to raise our voices for the #braintumor community. Please: Co-sponsor the BRAIN Act (H.R.2767/S.1330) Support FY26 brain tumor research funding back a Childhood Cancer Package.
Thank you! #BTSM
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Guy Lipof - גיא retweeted
Why join @gliomaregistry?
Your voice can make a difference. Help us better understand risk factors for gliomas, compare the effectiveness of treatments, & develop resources tailored to the unique needs of the glioma community.
🌐gliomaregistry.org
✉️glioma@yale.edu
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Apr 17
Multi-institutional work from the UK, China, and New Zealand on glioma liquid biopsy. Using plasma small extracellular vesicle (sEV) profiling across multiple cohorts and multiomics methods, the authors show that distinct molecular signatures can reliably distinguish glioma subtypes.
The approach shows promise for tracking treatment response over time, and could become a clinically useful tool for diagnosing glioma, defining molecular subtypes, and guiding more personalized treatment decisions.
cell.com/cell-reports-medici…
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Apr 17
A comprehensive article out of Lebanon on glioblastoma, focusing on tumor-associated macrophages and how they drive blood–brain barrier disruption and tumor progression.
Hopefully when this war ends, Lebanese researchers will have the opportunity to collaborate with peers in Israel.
Science should be a bridge, not a casualty.
academia.edu/3071-4087/2/1/1…
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This is an interesting open access article by Dutch researchers in @NatureMedicine, Real-world clinical utility of tumor whole-genome sequencing in solid cancers. Some key observations:
In 8% of patients, WGS identified additional biomarkers that NGS did not capture for whom NGS identified at least one biomarker.
27% of patients were eligible for a reimbursed biomarker therapy. 40% of that subset started that treatment.
A subset of patients switched targeted therapies because WGS revealed resistance.
63% of patients had actionable experimental biomarkers, 19% of them began treatment (16% via clinical trial, 3% via compassionate use/ early-access programs).
doi.org/10.1038/s41591-026-0…
Mar 25
Real-world clinical utility of tumor whole genome sequencing in solid cancers
@NatureMedicine
doi.org/10.1038/s41591-026-0…
👉actionable biomarkers in 73% of pts (27% for reimbursed and 63% for experimental💊
👉clinical consequences for 41% of tested pts
🧐NGS is key today
@myESMO @ASCO
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Guy Lipof - גיא retweeted
Mar 31
This really is excellent news and offers the first new drug treatment for low grade glioma in decades.
Well done to all the charities and campaigners who made this happen.
@BrainTumourOrg @astrofund @TJBCMission @braintumourrsch @brainstrust
In a fitting end to #BrainTumourAwarenessMonth2026, @NICE has approved vorasidenib for use for some low grade gliomas. Read More: bit.ly/4bYnPlI
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How classy of @Martina. Not sure what part she found so offensive, but I hope her day improves.
Stick to tennis, @Martina. Israel is acting within the framework of UN Security Council Resolution 1701. If Lebanon wants to exercise full sovereignty in the south, it must disarm Hezbollah and uphold its agreement commitments.
After October 7th, Israel is rightfully done listening to feckless westerners.
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I hope one day the people of Iran, Israel, and Lebanon can live in peace together. Alas, the Islamic regime and Hezbollah impede our coexistence. May we dance together soon.
x.com/project2program/status…
26 Oct 2024
One day the people of Iran, Israel, and Lebanon will dance together. May that day come sooner than later.
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Mar 28
Pahlavi’s statements are at the core why the Islamic regime must fall. May the people of Iran and the Middle East be free from the oppression and terror we have all endured at the hands and direction of the mullahs, IRGC, Basij and their proxies.
The Iranian regime slaughtered 40,000 of its own people—and then billed grieving families for the bullets that killed their freedom-fighting children..
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Guy Lipof - גיא retweeted
Feb 28
I agree war was inevitable and I’ve been saying that for over two decades. The JCPOA and every other diplomatic effort were really about delaying war, not eliminating the threat. The only scenario where war was avoided was genuine reform by the Islamic regime, and there was never a real chance the mullahs would do that, even with President Obama’s wishful thinking.
So here we are. With the proxies badly weakened, IRGC air defenses effectively neutralized, and public unrest inside Iran, this is the strategic moment. President Trump is rightfully seizing it. We’ll see whether the pro-JCPOA talking heads were right, or whether the revolutionary regime turns out to be a paper tiger.
I hope the war is short. I hope the Iranian people are finally free. And above all, I hope our service members and our allies stay strong and come home safe.
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Guy Lipof - גיא retweeted
Feb 23
There are a small number of patriots in my generation who are fighting at the highest levels in a clear-eyed way for the USA and our civilization, and having a hugely positive impact.
@ssankar is one of them.
Shyam would have been very successful regardless, but I over-ruled a veto to hire him early at Palantir, and we’re lucky for it, and all learn a lot from his leadership. Great article about him in Colossus.
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“What people don’t understand is that the argument that, you know, ‘Maybe our institutions are too powerful and we should be throwing sand in the gears, not making them more effective’—that just has deeply corrosive effects,” he said, breaking the facade of childlike optimism for the only time during our interviews, growing slightly indignant as he reached for the same words he’d used to describe what nearly swallowed his family when he was a boy. “It’s a form of institutionalizing corruption. Like, why do you think nothing works in Nigeria or India? It’s because the cultures are corrupt. The systems are bankrupt, and people just live with it or get overwhelmed by it. The entropy of the universe is towards that sort of corruption.”
“America’s always been able to push back against that and basically have things that function,” he concluded, switching registers and settling back into his chair. “It waxes and wanes throughout history. But we’re in a period of really fighting for that now.”
Feb 23
Shyam Sankar is Palantir's chief technology officer and the man most responsible for making its business and technology work.
He joined in 2006 as employee #13, when Palantir was one of Silicon Valley’s freakshows: a small and somewhat demented chickenhawk of a startup with a buggy demo and no customers. For 20 years, largely from the shadows, he has brute forced it into the spearhead of "defense tech" and a $320 billion company.
He embedded with intelligence analysts in Virginia, special operators in Iraq and Afghanistan, and on the factory floors of some of the world’s biggest companies—building and rebuilding software in the field, sometimes with phones taped to his head so he could give and take feedback while keeping his hands free to code. He invented the “Forward Deployed Engineer,” which has since become the object of both skepticism and imitation.
Alex Karp, Palantir's mercurial co-founder and CEO, says the company would not exist without him. The same can be said of the modern defense tech industry, many of whose founders cut their teeth working for Shyam.
In this deeply reported profile, @JeremySternLA tells the story of the most pivotal but hidden figure behind America’s most controversial company. He also gives the clearest explanation you'll read of what Palantir actually does, whether its valuation is justified or absurd, and what any of this has to do with the company’s mission to save Western civilization.
It begins in the Grand Ballroom of The Pierre hotel and winds through Nigeria and India, Florida and California, Iraq and Afghanistan. It ends with a rabbi, a monkey, and a lesson in what it means to buy time in the face of a coming fire.
Only in Colossus:
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Feb 26
“The most effective form of influence is the one that feels like your own conclusion.” - @peterhimmelman
Feb 24
Sun Tzu, Anti-Zionism, and the Strategic Blindness of the West (Essay on China’s Support for the Islamic Republic of Iran’s Strategic Survival) "Young people in cities thousands of miles from Tehran began reciting phrases that mirrored the ideological language of the Iranian regime. Protest encampments developed their own visual codes, their own rituals, their own liturgy of resistance. Printed placards appeared with identical typography. Chants rose and fell in practiced cadence." Read the essay: peterhimmelman.substack.com/… @yudapearl @DavidSuissaJJ @havivrettiggur
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Guy Lipof - גיא retweeted
The cellular and mutational origins of IDH mutant glioma #neuropath
doi.org/10.1093/neuonc/noag0…
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Guy Lipof - גיא retweeted
More powerful than USA winning gold in hockey was when the team invited the kids of their deceased teammate onto the ice.
Johnny Gaudreau lost his life to a drunk driver in 2024.
Want to honor him and his family?
Don’t drink and drive.
RIP Gaudreau.
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Feb 14
On my recent drive between Austin and Houston, I listened to the latest @NeuroOnc podcast. It was with Dr. David Solomon, director of neuropathology at @StanfordMed. His research discussed was on how key genomic alterations in high-grade glioma (specifically IDH-wildtype and IDH-mutant) evolve and how these insights might inform therapeutic development. #BTSM
soc-neuro-onc.libsyn.com/hot…
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