What's going to be different with the new IMWG response criteria?
Main changes:
- FLC >=10 mg/dL with abnormal ratio takes precedence over urine (but urine is not gone)
- No more sCR
- Bone marrow to confirm CR can be performed /- 6 weeks from blood testing.
- 24-hour urine at baseline, and if M-protein present, retest only to confirm CR
- Patients can be considered to have PD if they meet criteria by a variable not considered measurable at baseline (major weakness with current response criteria is that it misses light chain escape).
Next, imaging....