In our recent Sci. Signal. paper by Gutjahr et al. @GutjahrJulia 10.1126/scisignal.adt2678 we did not discuss in detail this point: "Using CXCL12 should improve the efficiency of in vitro blood production" Fortschritt in der künstlichen Blutproduktion idw-online.de/-DQuTAA
Un joli erythroblaste.
Un érythroblaste est une cellule jeune de la lignée des globules rouges, présente dans la moelle osseuse. Elle contient encore un noyau, ce qui la distingue des globules rouges matures (érythrocytes), qui en sont dépourvus.
In a new study, researchers find that the chemokine CXCL12 can support the production of red blood cells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells.
Learn more in @SciSignal: scim.ag/4kTxFZz
In a new study, researchers find that the chemokine CXCL12 can support the production of red blood cells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells.
Learn more in @SciSignal: scim.ag/4kTxFZz
A preclinical study uncovers a metabolic pathway that offers a target in neuropathic pain, scientists discover how chemokines can support red blood cell production in mice, and more this week in #ScienceSignaling. scim.ag/3HEv8no
Not all chemokine signaling is about cell migration!
In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation.
🔗 science.org/doi/10.1126/scis…#chemokine#CXCR4
science.org/doi/10.1126/scis… We describe the hitherto overlooked expression of CXCR4 in erythroblasts, which do not migrate in response to CXCR4 ligation by CXCL12. Instead, CXCR4 localises to the nucleus and mediates alternative responses in erythroblast maturation and enucleation
Although chemokines are known for their role in cell migration, new work in mice shows that CXCL12 also promotes the differentiation of #erythroblasts by promoting CXCR4 signaling and activity in the nucleus. @stevenduke@GutjahrJulia@QMULWHRIscim.ag/446wONU
Proud to share that our recent publication in Science Signaling has been featured on the Science website today! 🧬🔬 It’s a great feeling to see our work reach a broader audience. Many thanks to all collaborators Check out the feature here: science.org/#Science