#SaubereLuft #CleanAir #FrisseLucht #CO2 @CO2meetactie igoe.at/saubere-luft/

I’m so excited. My secret (not so secret) observational experiment is about to begin. This is a once in a lifetime opportunity for wastewater surveillance. FIFA World cup. 1/ @SecureBio scientificamerican.com/artic…

Not everything will go on our public dashboard, but everything will be shared with Public Health in real time. I don't know what we will detect, but I’ll bet there will be something that comes along for the games. Either way, we’ll be watching. 7/7 dholab.github.io/public_viz/…

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As I’ve always suspected: Genetic predisposition! Your genes don’t just raise your risk, 🚨They could turn a past COVID-19 infection into a lifelong sentence of dangerous blood clotting! ➡️“COVID-19 acts as a long-term modifier of inherited thrombophilia phenotypes.” ➡️“Incorporating genetic profiling into post-COVID evaluation may enable precision identification of individuals at risk for persistent hypercoagulability.” 🤔Interesting Russian study! #AvoidSars2 #AvoidReinfections link.springer.com/article/10…

The most interesting thing in this report isn’t the 1,000th H5N1 case. It’s that WHO quietly documented 10 human infections with novel influenza viruses in just five weeks: • 3 H5N1 • 1 H5N6 • 5 H9N2 • 1 H1N2v Across Asia and North America.

Pediatric Post-Acute Sequelae of SARS-CoV-2 Infection in Taiwan: Insights from the DISCOVER Cohort 🚨We’ve called for caution and we’ll do it again!! #OurChildren #Omicron Even MILD paediatric COVID isn’t harmless. ➡️INTERESTING new Taiwan DISCOVER cohort (n≈500 kids, mean age7.6ys, post-2022 Omicron): 1. High burden of persistent multisystem symptoms: - Even though acute COVID-19 was predominantly mild, a substantial proportion of children developed post-acute sequelae of SARSCoV2 (PASC/long COVID) lasting >4 weeks, - The most common symptoms were fatigue, cough, chest pain, and other somatic complaints, - Neuropsychiatric issues (sleep disturbances, brain fog, anxiety/depression) affected 5–15% of cases, particularly adolescents, and correlated with reduced quality of life, 2. Subclinical organ dysfunction frequently missed by routine tests: - Impulse oscillometry detected abnormalities in 74.6% of assessed children (mainly small-airway dysfunction in 62.9%), strongly linked to respiratory symptoms, - ‼️Conventional spirometry was often normal, - ‼️AI-enhanced echocardiography (ResNet-50 model, 96.6% accuracy) unmasked subtle cardiac changes not visible on standard echo, 3. Immune-driven mechanism: - Symptom severity tracked with elevated anti-nucleocapsid IgG titers and a low-grade “cytokine simmer” (elevated IL-2, IL-21, MIP-1α) plus T-cell exhaustion markers (PD-1/PD-L1 correlation), - No evidence for viral persistence, 4. Vaccination modifies disease course: - ‼️Fully vaccinated children had significantly lower odds of gastrointestinal sequelae (abdominal pain AOR 0.49; diarrhoea AOR 0.37) and better-preserved pulmonary function (improved impulse-oscillometry parameters), 5. Vitamin D supplementation may show early promise: - A small single-center RCT (n=33) found 2,000 IU/day for 6 months significantly reduced overall symptom burden (CSSI-24 score), lowered pro-inflammatory cytokines, and favourably altered immune checkpoints and the microbiome, especially in children with vitamin D deficiency plus VDR risk genotypes, 6. Additional risks identified: -Older age and greater acute-infection severity predicted worse PASC, - ‼️The cohort also showed an elevated hazard of new-onset allergic diseases (asthma, rhinitis, dermatitis) post-infection. ‼️So, AGAIN, even mild pediatric SARS-CoV-2 infections can trigger long-lasting multisystem damage and impaired quality of life. Persistent symptoms in children must never be dismissed as “just recovery/getting over it” but need prompt specialist evaluation and intervention! Dammm it….protect our children and don’t relax after at first sight “normal” tests! #CleanAir #AvoidSars2 #AvoidReinfections pediatr-neonatol.com/article…

Let's say you're a dairy farmer. You have 100 cows. Each year, about 5 cows die, and another 5 cows are born. Then, along comes a virus. Let's call it "cowvid"... 1/

Good. I'm glad WHO has warned that Andes Hantavirus may be spread person to person by airborne particles. That's what they should have done with Covid in Feb 2020. Then in March 2020 they should have said "Yes. There's no maybe. Covid is spread by airborne particles".

Wonderful day for a new #LongCOVID paper! Thanks to an incredible collaboration with @VirusesImmunity and brilliant work done by @keylas3, we studied the effects of injecting antibodies taken from people with LC into mice compared with what happened sciencedirect.com/science/ar… 1/

My concern is that if Bundibugyo Ebola is delaying innate immune detection even slightly, chains could be much harder to catch early because people can stay mildly unwell and mobile for longer before severe symptoms force recognition of underlying disease.

🚨 A Tiny Pill Could Change Bone Health Forever Scientists in Japan have developed an experimental pill that may rebuild weak bones and help reverse osteoporosis. Unlike traditional treatments that only slow bone loss, this new breakthrough could help the body create stronger bone tissue again. Early studies show improved bone strength and reduced fracture risk, giving hope to millions affected by fragile bones and aging-related weakness. Could the future of stronger bones really fit inside one small pill? Source: Kyodo News. Japanese researchers develop experimental osteoporosis pill that may rebuild bone tissue.

Diese Woche gehts bei viroLOGISCH um den laufenden Ausbruch mit Bundibugyo Ebolavirus. ➡️ Spotify: open.spotify.com/show/7FXqAH… ➡️ Apple Podcasts: podcasts.apple.com/at/podcas… ➡️ Podigee: virologisch.podigee.io

The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer. ✓ out the new Ground Truths (link in profile)

Association of long-COVID with major adverse cardiovascular events and mortality: a real-world data cohort study 🚨Still not shocked: L0NGC0VID patients are 4.5× more likely to suffer heart attacks, strokes & deadly clots, and 53% more likely to die? WAKE-UP! ➡️Large retrospective cohort study used TriNetX real-world electronic health records (~118 million US patients) to assess long COVID’s impact on cardiovascular outcomes, ➡️ Adults (≥18 years) diagnosed with COVID-19 (2020–2023) were included. The long-COVID group (diagnosed 3–6 months post-infection) was compared with matched non-long-COVID controls after 1:1 propensity-score matching (86,122 per group, balanced on demographics, comorbidities, vaccines, etc), ➡️ Primary outcomes: major adverse cardiovascular events (MACE: coronary artery disease, stroke, myocarditis, heart failure, pulmonary embolism) and all-cause mortality, with follow-up starting 90 days post-index date (mean ~3 years), ➡️Long-COVID patients showed markedly higher MACE risk (HR 4.48, 95% CI 3.95–5.07), driven by coronary artery disease (HR 6.48), stroke (HR 3.46), and pulmonary embolism (HR 4.35), ➡️All-cause mortality was also elevated (HR 1.53, 95% CI 1.38–1.69), ➡️Risks remained consistent across 1- and 3-year follow-ups, age, sex, race, BMI, hospitalization status, antiviral use, and SARS-CoV-2 variant periods (Alpha/Delta/Omicron), ➡️Mechanisms discussed include ACE2-mediated myocardial injury, endothelial damage, chronic inflammation, and autonomic dysfunction, ➡️Pre-existing cardiovascular conditions were excluded to isolate long-COVID effects, ‼️So, patients with long COVID face a substantially elevated risk of major adverse cardiovascular events and all-cause mortality compared to those without long COVID, underscoring the need for vigilant long-term cardiovascular monitoring in this population, “This multicenter real-world cohort study demonstrates that patients with long COVID have a significantly higher risk of major adverse cardiovascular events (MACE) and all-cause mortality compared with those without long COVID” #AvoidSars2 #AvoidReinfections #YouOnlyHaveOneHeart link.springer.com/content/pd…

COVID raises your shingles risk. New data from 110,000 patients out of Taiwan shows that post-COVID Shingles also raise risk of ➡️ Bell's palsy ➡️ Guillain Barré ➡️ Myasthenia Gravis Worst of all? Neurological vulnerability lasts for at least 3 years. buff.ly/H1N73zd

We have known for a while that #LongCOVID pathobiology for many involves reactivation of various herpesviruses. As we continue to validate this it is great to see this work coming out in collaboration with @VirusesImmunity’s incredible team. Here we medrxiv.org/content/10.64898… 1/

Hey. This is a cause close to my heart. If you can follow and reshare and stuff, I'd really appreciate it. ❤️

From an autopsy-based case–control study, "COVID-19–positive cases demonstrated significantly increased reactive gliosis and microglial activation in the olfactory bulb, along with a higher frequency of mild perivascular lymphocytic infiltration in the frontal cortex.. Systemic pathological findings in COVID-19–positive cases were consistent with severe multisystem disease. [In conclusion,] COVID-19 is associated with region-specific but non-uniform neuropathological alterations dominated by reactive and vascular changes rather than encephalitic processes." People change after contracting COVID. 'Histopathological changes in the olfactory pathway in COVID-19: An autopsy-based case–control study' link.springer.com/article/10…

I’m so incredibly frustrated. We have an outbreak report for the cruise ship, published in NEJM, and great clinical, epidemiological, and genomic reporting, and… NOT A SINGLE MENTION OF VENTILATION/FILTRATION SETUP ON THE SHIP Folks, we keep doing this. A lot of MD/PhD coauthors on the “Andes Virus Outbreak Working Group”, and no one with expertise on mechanical systems. And no one on the team even thought to check or investigate it. It’s malpractice at this point, and I’m not exaggerating in my use of the term. I do investigations in buildings and if I failed to check the status of the mechanical systems I’d be sued. (It’s actually *the first* thing I check) @NEJM: see our report from The Lancet COVID-19 Commission on this in the thread. Include this in your reviews. Mandate this info in every outbreak investigation report. The reason I first called the doctor on the ship was because I wanted to see if he could get info on the ship’s systems before he left it, bc I knew the official investigations would miss it. Because they always do.

You can read the full text of Baroness Linforth’s wonderful speech in the House of Lords about the urgent need for clean indoor air in schools here ⬇️ hansard.parliament.uk/Lords/…