PhD, Medical Genetics from @UBC @CMMT_UBC 🧬 Investigating synthetic lethality in DNA repair pathways @BCCancer šŸ„ Opinions are mine, RT/like ≠ endorse

Joined January 2021
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I’m very excited to share that my PhD work is now published @eLife! We used a combination of genetics, cell biology and biochemistry to identify a new endosomal complex in yeast, which we named VINE 🌿 Early access here: elifesciences.org/articles/7…. (1/n).
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Shawn Shortill retweeted
"Reliable protein-protein docking with AlphaFold, Rosetta and replica-exchange" Some promising results on antibody-antigen complex prediction biorxiv.org/content/10.1101/…
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Interesting paper, awesome name for a shortened BAR domain!
MiniBAR has a unique truncated BAR domain, is a dual Rac / Rab #GTPases effector and controls both actin cytoskeleton and membrane trafficking in ciliogenesis. #RabGTPases #RhoGTPases #actin #myosin #membranetraffic #ciliopathies #zebrafish #cilia
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Yeast friends—this is an interesting approach to getting around stubborn, tag-intolerant proteins for imaging studies
"Here, we successfully use LIVE-PAINT to image yeast membrane proteins that do not tolerate the direct fusion of a fluorescent protein by using peptide tags as short as 5-residues" biorxiv.org/content/10.1101/…
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Shawn Shortill retweeted
Finally the community has a reliable, specific and high affinity probe to detect PI(3,5)P2 ! I am very excited about the new insights that this new tool will deliver about how this rare phospholipid controls diverse cellular events. Been great working on this with @jasonkinglab
Vines et al. from @jasonkinglab with collaborators @hannes_maib @soldatilab describe a new tool for imaging the mysterious signaling lipid PI(3,5)P2 in live cells for the first time. bit.ly/3CTnOyA #Membrane #lipid
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I’m excited to share that after five amazing years with @conibear_liz and @UBC @CMMT_UBC, I have defended my doctoral dissertation and finished my PhD in Medical Genetics. We made some exciting discoveries over the years, and published papers that I’m truly proud of. 1/n.
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Most of all, I want to thank @conibear_liz for being such an inspiring mentor and fiercely creative scientific role model. It was a privilege to work in the Conibear lab, and it wouldn’t be possible to synthesize all of the things I learned from Liz into a single tweet. (3/n).
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For my next steps, I’ll be joining @pcstirling and @HieterLab to leverage synthetic lethality in DNA repair pathways for the treatment of various cancers. Stay tuned for more! 4/4.
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Shawn Shortill retweeted
Arrowsmith Genetics is excited to be in Round 3 of the New Ventures BC competition. Looking forward to meeting our mentors and other NVBC ventures. #NVBC2023 #BCtech #BCentrepreneurs
23 Jun 2023
šŸŽ‰ Congratulations to this year's Round 3 competitors in the 23rd Annual New Ventures BC Competition, presented by Innovate BC! Find the #NVBC2023 Top 25 ventures on our blog: ow.ly/vlsX50OWgsF #NVBC2023 #BCtech #BCentrepreneurs
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A good perspective on the new changes @elife from a senior editor:
as a long time seniorĀ editor for @eLife I (MJF) thought I'd weigh in. When I first heard about the plan in its initial conception, I had my reservations for many of the same reasons some of you articulating. I've changed my mind. I think it is worth a shot
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We have all (rightfully) complained about how flawed the current science publishing system is. The @eLife team is now challenging this status quo by abandoning the traditional ā€œaccepted manuscriptā€ title to instead publish everything that gets reviewed, along with an assessment.
Today, we’re introducing a new model that eliminates accept/reject decisions. By publishing every paper with eLife reviews as a Reviewed Preprint, we plan to restore autonomy to authors, ensuring that they will be judged by what, not where, they publish. elifesciences.org/inside-eli…
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Manuscript accepted!! šŸ•ŗšŸ¼šŸ¾ This was a large, multi-lab project and I’m happy to have contributed to its success. Stay tuned for yeast membrane contact sites, lipid biology and a first glimpse at the (very) complicated inner workings of a potential new lipid transport protein—Lec1

ALT Yes Baby GIF

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Normalize bedroom genome assembly and annotation šŸ›ļøšŸ§¬
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Shawn Shortill retweeted
17 Oct 2022
Come work with us - exciting opportunity to get in at the early stage and substantially contribute to shaping the future and development of a new interdisciplinary and ambitious research program @UBCmedicine @UBC @UBCAging
We're hiring! We are looking for a research coordinator to help facilitate healthy #aging research, education & knowledge mobilization @UBC. If you are a dedicated, organized & creative individual looking for a new opportunity check out the job posting: bit.ly/3gauwrC
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Congratulations @SaketBagde! This is so exciting and well deserved
22 Sep 2022
Congratulations to our own @SaketBagde for winning the Spicer Young Investigator award!!!! šŸŽ‰šŸŽ‰šŸŽ‰ slac.stanford.edu/news/2022-…
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Thank you Cheryl Bishop for all your years of service in Medical Genetics. You will be missed. We wish you a very happy retirement!
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Shawn Shortill retweeted
Prince Charles updating his email signature like PhD students after passing their candidacy exams
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Shawn Shortill retweeted
A sneak peek inside Victoria’s former Canoe Club. Officially opens as CRAFT sometime in September. #yyj
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30 Aug 2022
We're humbled to be recognized this year by @Newsweek as one of the top ten pediatric hospitals in the world! Each day we're inspired by the incredible team at BC Children's Hospital & are grateful to our community of supporters who help make their advances possible šŸ™ #thankyou
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