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Tommaso Perini @Tom_Perini

Physician scientist working on multiple myeloma @SanRaffaeleMI @MyUniSR. Passionate about cancer cell biology and its translational potential.

Joined August 2022
  • Tweets 79
  • Following 279
  • Followers 72
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Tommaso Perini@Tom_Perini
12 Sep 2025
🍾I am happy and proud to share with you the official publication of our latest results, now available in @BloodPortfolio 🔬Thanks to the application of in vitro and in vivo models, we show that ClpP is a metabolic and immunogenic vulnerability in #mmsm ashpublications.org/blood/ar…

The mitochondrial protease ClpP is a metabolic vulnerability and an immunogenic trigger against...

Key PointsMyeloma cells depend on the mitoprotease ClpP to sustain polyamine biogenesis through restricted ornithine aminotransferase activity.ClpP inhibit

ashpublications.org
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Tommaso Perini retweeted
Nikhil C. Munshi, MD@NikhilMunshiMD
13 Dec 2025
Very important new paper in JCO by Samur et al on SMM - will change our thinking! @VincentRK @NoopurRajeMD @szusmani @myelomaMD @SagarLonialMD @mvmateos @IrenemGhobrial ascopubs.org/doi/10.1200/JCO…

Genomically Smoldering Multiple Myeloma Is Not a Distinct Entity But a Collection of Monoclonal...

PURPOSEThe diagnosis of smoldering multiple myeloma (SMM) primarily relies on clinical features such as plasma cell involvement, immunoglobulin protein levels, and end-organ damage. However, as early...

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unisr.it/news/2025/11/nuovo-…

Un nuovo approccio per potenziare l’immunoterapia nel mieloma multiplo

unisr.it
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We are really proud to share our work on the role of ID2-TCF3 axis in myeloma! Thanks @mtfulciniti and @NikhilMunshiMD for the amazing collaboration
Robert Z. Orlowski@Myeloma_Doc
18 Oct 2025
#Myeloma Paper of the Day: ID2 suppresses multiple myeloma cell proliferation by repressing the activity of the transcription factor TCF3; BM milieu supports this by further decreasing ID2 expression & enhancing TCF3 activity, partly via IL-6: pubmed.ncbi.nlm.nih.gov/4110…. #mmsm
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Tommaso Perini retweeted
OncoDaily
@oncodaily
18 Oct 2025
Myeloma Paper of the Day, October 18th, Suggested by Robert Orlowski (@Myeloma_Doc) @BCD_AACR @mtfulciniti oncodaily.com/voices/myeloma… #OncoDaily #Oncology #Cancer #Health #Medicine #MedTwitter #MedEd #MedOnc #MedNews #MM #Myeloma @CancerWorldmag
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🍾I am happy and proud to share with you the official publication of our latest results, now available in @BloodPortfolio 🔬Thanks to the application of in vitro and in vivo models, we show that ClpP is a metabolic and immunogenic vulnerability in #mmsm ashpublications.org/blood/ar…

The mitochondrial protease ClpP is a metabolic vulnerability and an immunogenic trigger against...

Key PointsMyeloma cells depend on the mitoprotease ClpP to sustain polyamine biogenesis through restricted ornithine aminotransferase activity.ClpP inhibit

ashpublications.org
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more replies
💊We establish for the first time the proof of principle that targeting mitochondria can have a twofold effect in myeloma, both limiting cell growth and boosting anticancer immunity and the efficacy of novel immunotherpautics.
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Thanks to all the amazing people involved, in particular to my phantastic co-authors Paola Zordan and @Bellone_lab @Boletta_Lab @MMaterozzi @NikhilMunshiMD @StefanoniDavide
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Tommaso Perini retweeted
VJHemOnc
@VJHemOnc
13 Jun 2025
#EHA2025 It is always a pleasure to catch up with @ScarfoLydia! She spoke about all things CLL🩸 ⭐️Updated findings on the BTK degrader BGB-16673 ⭐️Optimizing frontline CLL treatment ⭐️The use of time-limited BTKi–BCL2i options Coming soon to VJHemOnc.com📹 #Leusm #CLLsm #HemOnc
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A novel approach to degrade evil MYC in #mmsm presented #EHA25 ! Great job @maidom_ and all the team at Morelli lab and @NikhilMunshiMD lab!
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Brilliant work by @NikhilMunshiMD lab and great presentation by @ASchavgoulidze at #EHA25 ! These studies will hopefully pave the way for novel treatments for del17p #mmsm
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Our paper on a novel role for ClpP and mitochondria in #mmsm is finally out @BloodJournal !! pubmed.ncbi.nlm.nih.gov/4030… A special thank you to our amazing coauthors Paola Zordan and Matteo Bellone @Bellone_lab and to all the people involved! Here is our discovery in just one 🖼️
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We found that without ClpP MM cells: 🛢️ do not produce enough polyamines, an oil for the cancer engine, and thus stop growing 🦠release mitochondrial DNA that is recognized as "bacterial" by cGAS-STING 🔥release immunogenic signals that boost anti-MM immunity
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@MMaterozzi @Boletta_Lab @NikhilMunshiMD @StefanoniDavide @CiceriFabio @MyUniSR @SanRaffaeleMI
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Tommaso Perini retweeted
Itai Yanai
@ItaiYanai
25 Dec 2024
It’s crazy how talking with a science buddy is simultaneously what’s most likely to move the project forward and the thing that’s least prioritized in our schedule.
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So happy and honored for the opportunity to present my work on mitochondrial protease CLPP at #ASH24 ! Thanks for the support of all the friends and the positive feedbacks of great scientists! Stay tuned for the complete story!
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Diet can work as secondary prevention in MGUS/sMM! stellar @UrviShahMD
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Excited to be at #ASH24!! Grateful for the opportunity to share our data and ideas on mitochondrial proteases in myeloma on Monday!
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Really wonderful talk as usual @vago_luca Congratulations for your amazing work! #ASH24
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