Official account Section Translational Cancer Epigenomics @TMO_Heidelberg @NCT_HD @DKFZ, #epigenomics, #hematopoiesis, #JMML, #singleCell, #precisiononcology
Joined June 2022
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🧵 NEW PAPER in @BloodJournal!
Why do IDH1 mutations almost exclusively drive myeloid #leukemia, while IDH2 mutations occur in both myeloid AND lymphoid cancers? #AML #Epigenetics
Despite sharing the same biochemical mechanism, they are NOT equivalent. Here's what we found 👇
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Decades of research have revealed the intricacies of how dendritic cells (DCs) function, but fundamental questions remain about how this group of cells develops in humans and how this process goes awry in disease. A thread on our new work! (1/9)
biorxiv.org/content/10.64898…
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Translational Cancer Epigenomics retweeted
📢Another exciting seminar on CCEC, scheduled on Friday 6thJun@3PM,UKtime with Alvaro Rada Iglesias @IBBTEC Cantabria.
Alvaro will discuss: Enhancer-Promoter contact, a key feature in gene regulation, how and why?? link2join us06web.zoom.us/webinar/regi…
@ShuchiChromaBio
@activemotif
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🧵 NEW PAPER in @BloodJournal!
Why do IDH1 mutations almost exclusively drive myeloid #leukemia, while IDH2 mutations occur in both myeloid AND lymphoid cancers? #AML #Epigenetics
Despite sharing the same biochemical mechanism, they are NOT equivalent. Here's what we found 👇
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12/ To summarise:
→ IDH1 is highly expressed in myeloid progenitors (unlike IDH2)
→ Mutant IDH1 epigenetically silences Cebpe → neutrophil block
→ The block persists after IDH1 inhibition alone
→ IDH1i hypomethylating agent fully rescues the defect
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13/ Huge congratulations to first author @MariamHakobya20 and all collaborators and a big THANK YOU for all your efforts and support throughout the project! 🎉
📄 Paper link 👇
doi.org/10.1182/blood.202503…
#AML #Leukemia #IDH1 #Epigenetics #Hematology #BloodCancer @DKFZ @NCT_HD
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Translational Cancer Epigenomics retweeted
Grateful to @JianXuLab for this perspective highlighting how oncogenes, developmental ontogeny, and cellular plasticity intersect in pediatric leukemia, alongside the JMML study by @mp_hartmann and @dblipka1. @BCD_AACR @CD_AACR aacrjournals.org/bloodcancer…
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Translational Cancer Epigenomics retweeted
I can only agree with that!
Grateful to @JianXuLab for this perspective highlighting how oncogenes, developmental ontogeny, and cellular plasticity intersect in pediatric leukemia, alongside the JMML study by @mp_hartmann and @dblipka1. @BCD_AACR @CD_AACR aacrjournals.org/bloodcancer…
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Translational Cancer Epigenomics retweeted
Now online: Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia doi.org/10.1158/2643-3230.BC…
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Translational Cancer Epigenomics retweeted
Check out our latest story science.org/doi/10.1126/scie…! Huge thanks to @GauravA_UK and the @bloodgenes lab for driving this work forward together with us. This was a great team effort with outstanding collaborators @_ruslansoldatov, @AbdelWahablab, and @AlexBickMDPhD.
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Translational Cancer Epigenomics retweeted
11 Dec 2025
Here, in this @Cancer_Cell mini-review, we highlight recent advances in understanding oncofetal reprogramming and explore its emerging potential as a biomarker and therapeutic target in cancer research. @FGinhoux
sciencedirect.com/science/ar…
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