Scientist @DKFZ @NCT_HD @TMO_Heidelberg @TransCanEpi #epigenetics #stemcells #leukemia #multiomics #precisiononcology #oncofetal #reprogramming #plasticity
Joined November 2020
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Editors’ Pick by Cancer Research Catalyst
@AACR
RAS-driven plasticity and oncofetal reprogramming as a key mechanism and vulnerability in JMML.
The article is freely available for a limited time:
aacr.org/blog/2026/03/27/edi…
#hematology
#oncology
#epigenetics
#development
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Excited to share our work at the 2026 #ISEH Mini Symposium!
"Beyond the maturation block: oncofetal reprogramming & stem cell plasticity in pediatric leukemia"
Great lineup incl. @beth_psaila, Simón Méndez-Ferrer & Jian Xu
Join us April 16: iseh.org/Webinars-Events/Min…
@ISEHSociety
Mar 26
We are excited to announce the full Mini Symposium program featuring the short talks selected from submitted abstracts! Don't miss the chance to view groundbreaking research and choose the top short talk. View the full program and register ➡️ iseh.org/Webinars-Events/Min…
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Mark Hartmann retweeted
Read the March Editors' Pick:
Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia doi.org/10.1158/2643-3230.BC…
The March edition of Editors’ Picks from AACR journals includes studies on pediatric leukemia development, awareness of alcohol as a carcinogen, and more. Learn more on the #AACRBlog: brnw.ch/21x1aEw
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The March edition of Editors’ Picks from AACR journals includes studies on pediatric leukemia development, awareness of alcohol as a carcinogen, and more. Learn more on the #AACRBlog: brnw.ch/21x1aEw
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Mark Hartmann retweeted
We're hiring a new 3 yr postdoc!
Come join us at @SussexUni for exciting new @CR_UK funded project targeting RUNX1 mutations in CML in a highly supportive research environment within @Sussex_BCR @SussexLifeSci @BiochemBiomedUS @Sussex_Cancer
Apply 👇, advert closes 8th March.
New post: Research Fellow in Biochemistry & Biomedicine (Fixed Term)
Ref: 43139
Closing Date: 08 March 2026
To apply visit: jobs.sussex.ac.uk/job/4fee4e…
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I can only agree with that!
Grateful to @JianXuLab for this perspective highlighting how oncogenes, developmental ontogeny, and cellular plasticity intersect in pediatric leukemia, alongside the JMML study by @mp_hartmann and @dblipka1. @BCD_AACR @CD_AACR aacrjournals.org/bloodcancer…
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Mark Hartmann retweeted
Now online: Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia doi.org/10.1158/2643-3230.BC…
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New Spotlight in @BCD_AACR
#Oncogene × #Ontogeny × #Plasticity shape leukemia biology & therapy response.
Two complementary studies show: mutations alone don’t explain disease behavior—developmental state and cellular plasticity matter.
aacrjournals.org/bloodcancer…
#leukemia
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Same mutation ≠ same leukemia.
@Elvin_Wag et al. @CD_AACR
• fetal HSCs readily transform
• postnatal HSCs become resistant
• fetal programs create vulnerabilities
Ontogeny matters: state-of-origin shapes biology & therapy response.
doi.org/10.1158/2159-8290.CD…
#pediatric #AML
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JMML stem cells aren’t epigenetically “stuck” in a fetal state.
They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model.
doi.org/10.1158/2643-3230.BC…
#JMML #epigenetics
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Thank you @mtdialog for featuring our study:
Frühkindliche Leukämie: Fetale Programme reaktiviert - MT-Dialog mtdialog.de/news/artikel/fru…
#Kinderkrebs
#Leukämie
@DKFZ
@NCT_HD
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Mark Hartmann retweeted
8 Dec 2025
Now online: Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia doi.org/10.1158/2643-3230.BC…
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Mark Hartmann retweeted
11 Dec 2025
Here, in this @Cancer_Cell mini-review, we highlight recent advances in understanding oncofetal reprogramming and explore its emerging potential as a biomarker and therapeutic target in cancer research. @FGinhoux
sciencedirect.com/science/ar…
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Mark Hartmann retweeted
7 Dec 2025
Just published by Maximilian Schönung, et al. “Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia.” doi.org/10.1158/2643-3230.BC…
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Mark Hartmann retweeted
6 Dec 2025
Just published by Daniel B. Lipka, et al. “Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia.” doi.org/10.1158/2643-3230.BC… @dblipka1
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6 Dec 2025
Go and listen to this talk - exciting data, I promise!
6 Dec 2025
Interested in DNA methylation and want to hear what we can learn from it regarding lineage commitment decisions in #hematopoiesis? #ASH25 #epigenomics
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6 Dec 2025
ONLINE FIRST ALERT!
Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
aacrjournals.org/bloodcancer…
@BCD_AACR
@AACR
#childhoodcancer
#epigenetics
#precisiononcology
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6 Dec 2025
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