Gould Lab studies roles of #BasementMembrane and #ECMatrix, and finds cures of a multi-system disorder #GouldSyndrome caused by mutations in #collagenIV.
Joined April 2020
- Tweets 65
- Following 188
- Followers 245
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5 Photos and videos
Pinned Tweet
12 Apr 2021
Today April 12th is #GouldSyndromeAwareness Day because this disease is caused by mutations in the Col4⃣ a1⃣ and a2⃣ genes. Please find your time to watch this 4 min video
👇👇👇
youtu.be/VLWm_Cns99Y via @YouTube
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Gould Lab UCSF retweeted
8 Aug 2025
Thank you for advertising our new preprint, Yutaka! 📢
If you are interested in prolyl 4-hydroxylation and collagen biosynthesis, you can learn how these go in Drosoplia ‼️🪰🪰🪰
Happy Friday 😎
8 Aug 2025
Our preprint is out!
Great collaboration with @yoshihiro0604, @mel_toups, Marwan Elkrewi, Allison Zajac, and @SHBLab
Evidence for the major role of PH4⍺EFB in the prolyl 4-hydroxylation of Drosophila collagen IV
(13 posts follow) ↓
biorxiv.org/content/10.1101/…
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Gould Lab UCSF retweeted
26 Apr 2025
Please add your reading list! Our shiny collagen IV paper is out now😎 Enjoy beautiful red and green images! Yes, I MUST do molecular characterization of this "beauty" collagen IV... My TO-DO list is too much😅
@UCSFGouldLab
25 Apr 2025
Mao et al introduce a novel tagged Col4a1 mouse model for studying basement membrane dynamics, which provides important details of COL4A1 turnover in cerebral vasculature & shows that Col4a1 heterozygous deletion is better tolerated than missense mutations hubs.la/Q03jWjdz0
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Gould Lab UCSF retweeted
3 Jan 2025
My first post of 2025 is here! 😎 Excited to share my new paper on horse collagen I 🐎. We explored COL1 structure and modifications in horses with LH1 mutations. Don’t miss the unique images of twisted collagen fibrils—check it out below!👇👇👇
3 Jan 2025
Biochemical characterization of collagen I in Warmblood Fragile Foal Syndrome horse lysyl hydroxylase 1 mutation. #micropublication #biology #data #caltechlibrary # quus caballus #Biochemistry #NewFinding micropublication.org/journal…
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Gould Lab UCSF retweeted
Interesting collaboration coming from the @UCSFGouldLab and @TamaraAlliston lab to identify an unexpected role of #collagen type IV in bone biology in connection with #TGFβ bit.ly/3BxKlDy
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Gould Lab UCSF retweeted
13 Sep 2024
Want to learn about #GouldSyndrome? Check out this month's featured #CCMBM #MSK member publication from @UCSFGouldLab & @TamaraAlliston: "Skeletal pathology in mouse models of Gould syndrome is partially alleviated by genetically reducing TGFβ signaling." sciencedirect.com/science/ar…
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11 Sep 2024
Check out our new publication!
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Gould Lab UCSF retweeted
8 May 2024
Douglas Gould @UCSFGouldLab et al. investigate whether TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage, iovs.arvojournals.org/articl….
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Gould Lab UCSF retweeted
30 Mar 2024
We are please to announce Drs. Yoshi Ishikawa @yoshihiro0604 and Masashi Yanagisawa as the Luncheon Seminar speakers at #JSMBM24. 日本結合組織学会大会のランチョンセミナーはUCSF のYoshi Ishikawa 先生によるコラーゲンのフォールディング、Masashi Yanagisawa 先生による睡眠の講演です！
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Gould Lab UCSF retweeted
15 Mar 2024
What an incredible first day at the #Alportworkshop on #WorldKidneyDay - so much has happened in the last 10 years & always so good to catch up with #basementmembrane friends ❤️@JeffMinerPhD @UCSFGouldLab @SherwoodElegans @stramerlab
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17 Nov 2023
Exciting news! Our new research paper is published! This exciting study was done with a amazing collaborator Scott Early (@vesselman) lab. Congratulations🎉🍻🥳
15 Nov 2023
In a model of #GouldSyndrome, researchers connect brain lesions and hemorrhages to disruptions in #CalciumSignaling in smooth muscle cells from misfolded collagen, impairing vessel’s ability to regulate cerebral blood flow. @UCSFGouldLab @CobreUnr scim.ag/4Qh
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28 Oct 2023
#GouldSyndrome had great chemistry with #AlportSyndrome and basement membrane researchers at #ASMB2023! It is important to know each other, exchange ideas, and discuss future collaborations in person. I and @yoshihiro0604 are happy to be in this picture! Join Collagen IV biology!
27 Oct 2023
Charismatic #AlportSyndrome and basement membrane researchers at #ASMB2023 @amsocmatbio enjoying some "networking time" together after a full day of scientific sessions in SLC. Thanks to @AlportSyndFndn for generously supporting the conference! @RLWczyk @BoudkoSergei @RW_Naylor
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Gould Lab UCSF retweeted
3 May 2023
Looking for another exciting #ECMatrix conference before our biennial meeting? Check out the #Collagen #GordonConference, where our very own ASMB council member Doug Gould @UCSFGouldLab is vice-chair! 👇
grc.org/collagen-conference/…
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16 Mar 2023
We appreciate that someone like our study and share it with Twitter community! Thank you!
16 Mar 2023
#NAVBO Member Publication Alert
Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in #GouldSyndrome
Dr. Scott Earley group @PNASNews 2023 @UCSFGouldLab @vesselman
pnas.org/doi/full/10.1073/pn…
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11 Mar 2023
Beautiful work Earley lab! What a great collaboration!
10 Mar 2023
Our latest preprint provides proof of concept for the use of PI3K inhibitors to treat vascular dementia. @UCSFGouldLab @unrmed @DoctorMC_
PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease biorxiv.org/content/10.1101/…
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25 Jan 2023
Please check this latest publication we involved about Gould syndrome! Great work and excellent collaboration! Cheers! 👍🎉
24 Jan 2023
Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome | Proceedings of the National Academy of Sciences pnas.org/doi/10.1073/pnas.22…
Check out out latest paper, part of an amazing collaboration with @UCSFGouldLab !
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5 Dec 2022
Check our new paper!! Thank you @Xiaowei71 😊
5 Dec 2022
check out recent work from @UCSFGouldLab on how Col4 is involved in vascular function through TGFb pathway. New insights for vascular pathologies including CSVD and @GouldSyndrome AddThis | Home authors.elsevier.com/c/1gCCz…
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3 Nov 2021
Congratulations to Danielle @RyansMom2, Sheena, and everyone with @GouldSyndrome
1 Nov 2021
I am so proud to share the very first manuscript out of the @GouldSyndrome Global Registry! @SheelMd @UCSFGouldLab @LisaMarieShank sciencedirect.com/science/ar…
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19 Oct 2021
Finally, we could do a lab outing after the pandemic! Beautiful weather, excellent lab members and great foods/drinks made us happy! ☀️🍱🥂😎😁
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14 Oct 2021
Our collaborator wants young energies!! We look forward to working together 💪🔬🧫
12 Oct 2021
We are hiring two new postdocs! Come to Reno and help us develop new animal models of cerebral small vessel diseases (cSVDs) and vascular cognitive impairment and dementia (VCID). This is part of a great collaboration with @UCSFGouldLab and @DoctorMC_. jobs.sciencecareers.org/job/…
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22 Sep 2021
Happy National Postdoc Appreciation week to from the Gould lab to Kayla, Andrea, Xiaowei(@Xiaowei71), all former Gould lab postdocs and the rest of you hard working postdocs out there! 🔬🧪✍️💪🦾🙌
@UCSF Postdocs #NPAW2021 #ucsfNPAW
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