Really sad to hear of the passing of Beth Levine today. It is a huge loss to the autophagy community where she was a pioneer in the field. Our thoughts are with her family at this tough time.
Acquiring images of 3D solid spheroids can be challenging. Download our tech note to see a comparison of different optical clearing strategies for 3D spheroids, and quantification of their effectiveness and impact on spheroid morphology. ms.spr.ly/6017TzcvD
From: Cell Death Differentiation
The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death
nature.com/articles/s41418-0β¦
Researchers from the First Affiliated Hospital, Bengbu Medical College in China report Nf1 loss associated with #Kras driven #LungAdenocarcinoma, that depend on increased glutaminolysis --> therapeutic inhibition of glutaminase or Psat1
#openacess: bit.ly/2IXtHk3
In a recent study published in @NatureComms, Jefferson researchers showed that a gene called gasdermin E, which is downregulated in many cancers, aids cells in dying in an unexpected way, & may also suppress tumor growth: bit.ly/2PtTrFg#JeffersonResearch@JeffersonUniv
From: Cell Death Differentiation
BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL
nature.com/articles/s41418-0β¦