Looking forward to presenting our work at #ACSM2026 and contributing to the ongoing discussion on exercise biology, irisin, brain health, and MS at @ACSMNews. Our paper in @NatMetabolism nature.com/articles/s42255-0…

Excited to see our irisin–MS paper highlighted in Nature Metabolism — exercise may be a pathway to neuroprotective therapies. Read more: nature.com/articles/s42255-0… @RosenkranzSina @MGHNeuroSci @mghcvrc @MGBResearchNews @MGHBrainHealth

The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis dlvr.it/TSfYKP

Congratulations to @DavidChen_AIIH @DebbieKwonMD @zhao__ding for the paper in @NatureComms newsroom.clevelandclinic.org… Proud of what they accomplished and another great win for @CleClinicCIRC @CleClinicHVTI @ClevelandClinic

When muscle contracts during exercise, it releases proteins called myokines into the bloodstream. Myokines travel to the brain, liver, fat tissue, bones, and immune cells and instruct them to function better. Irisin, one of the most studied myokines, crosses the blood-brain barrier and directly stimulates the growth of new brain cells.

In a mouse model of multiple sclerosis, an exercise-linked hormone preserved neurons and eased symptoms—but when it was removed, exercise lost its protective edge. @MassGenBrigham medicalxpress.com/news/2026-…

Irisin, the muscle-derived hormone released during exercise, delivers direct neuroprotection in a mouse model of multiple sclerosis. Researchers delivered it peripherally and saw improved clinical scores, less neuronal loss across spinal cord, hippocampus, and retina, plus preserved synapses and mitochondrial function. It crossed the blood-brain barrier, bound motor neurons through upregulated αVβ5 integrin, and activated neuroprotective genes without touching immune pathways. Cognitive performance rose as a result. This separates the exercise benefit from immunomodulation and points to a targeted way to address MS neurodegeneration. One related human trial showed aerobic exercise raised serum irisin while improving motor and cognitive metrics in RRMS patients. The mechanism looks actionable for follow-on work thanks @EricTopol

The exercise hormone irisin promotes neuronal survival @NatMetabolism

irisin induction in response to exercise confers direct neuroprotective effects in an inflammation-driven neurodegenerative condition @NatMetabolism

exercise hormone irisin has neuroprotective effects in MS: Aerobic exercise is disease-modifying intervention in multiple sclerosis (MS), improves physical fitness of people with MS & ameliorates progressive neurological symptoms; exercise hormone irisin, nature.com/articles/s42255-0…

Exactly — our Nature Metabolism study shows irisin prevents neuronal loss in an EAE model, revealing a mechanism linking exercise to neuroprotection and potential therapeutic avenues. Thanks for highlighting this! @RosenkranzSina @MGHNeuroSci @mghcvrc @MGBResearchNews

Our new study in out in Nature Metabolism: the exercise hormone irisin mediates neuroprotection in a mouse model of MS — highlighting exercise‑based therapeutic potential. Proud of the team! nature.com/articles/s42255-0… @MGHNeuroSci @mghcvrc @MGBResearchNews @RosenkranzSina @MGHBrainHealth #MultipleSclerosis #Neuroimmunology #ExerciseMedicine #Neuroprotection #EAE #MSResearch

We appreciate Alzforum for spotlighting our latest research. Every step forward in understanding Alzheimer’s brings us closer to meaningful breakthroughs for patients and families.

Thrilled to see our new paper highlighted by Nature Neuroscience! Huge thanks to my amazing co-authors and collaborators. nature.com/articles/s41593-0…

We would like to thank the Alzheimer's Association for their generous support that made this research possible.

We like to thank the ADDF for their generous support!

Excited to share our collaborative work in @NatureNeuro, a collaboration with Wrann Lab! 🧠✨ A big step forward in understanding the role of exercise on Alzheimer's progression. Grateful to contribute to such an amazing team! #Neuroscience #BrainResearch #NatureNeuro