Associate Prof. @Weizmann Systems Immunology, Biochemical Immunology, Immunoproteomics, Proteasomes & Ubiquitin Biology Human & Translational Immunology
Joined August 2018
- Tweets 856
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5 Mar 2025
🚨Paper alert 🚨 Our latest research is out in @Nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ @WeizmannScience @Sys_Immunology
🔗 nature.com/articles/s41586-0…
🧵👇
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8 Dec 2025
🙏I’m deeply humbled to be included in Nature’s 10 for 2025. Grateful to my lab members, mentors, colleagues at Weizmann, and to my family and friends for their constant support. Our journey began with a small anomaly in the proteasome, a signal that revealed an unexpected layer of immune regulation. Excited for what lies ahead and committed to translating these insights to benefit human health.
@NaturePortfolio @WeizmannScience @ERC_Research @CancerResearch @ICRFONLINE @icrf_toronto
nature.com/articles/d41586-0…
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4 Jul 2025
Let’s not just hope — let’s act — for a future of peace and dignity for all.
Violence and hatred must end.
Humanity must lead, and science must light the way. 🙏💫🙏 nature.com/articles/d41586-0…
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10 Mar 2025
Humbled and honored 🫣
10 Mar 2025
You are welcome, your paper is completely fascinating
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10 Mar 2025
You are welcome, your paper is completely fascinating
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10 Mar 2025
Thank you for this amazing highlight of our work 🙏🙏🙏
9 Mar 2025
Top 5 advances in medicine this week (🧵)
1. An untapped treasure trove of antibiotics
The proteasome breaks down proteins that are no longer needed, but it turns out that some of the peptides it produces are repurposed as antibiotics
The top hit is a peptide derived from a serine/threonine phosphatase
This peptide kills a range of bacteria, including Pseudomonas and E. coli, and stopped mice dying from sepsis just as well as a conventional antibiotic
Study: nature.com/articles/s41586-0…
Comment: nature.com/articles/d41586-0…
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Yifat Merbl lab retweeted
5 Mar 2025
Protein waste turned into antibiotics in the proteasome as a innate defense strategy of human cells
@Nature @WeizmannScience @KarinGoldberg5 @YMerbl
nature.com/articles/s41586-0…
@NatureNV by @clausen_lab
nature.com/articles/d41586-0…
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6 Mar 2025
A big thank you to Tim Clausen (@clausen_lab) for writing such a thoughtful N&V about our recent paper!
nature.com/articles/d41586-0…
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6 Mar 2025
Thank you for the shout-out 🙏 and for the @ERC_Research's ongoing support! @WeizmannScience
6 Mar 2025
🆕 way to fight resistant superbugs? 🦠
ERC grantee @YMerbl and team @WeizmannScience revealed a secret defence in the immune system - reshaping our understanding of infection protection.
👉 bbc.in/3DnLBKL
👉 go.nature.com/3XvSX5Q
@Sys_Immunology #Immunology
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6 Mar 2025
Excited to see our work covered @BBCNews. Thank you @JamesTGallagher for covering it 🙏🙏🙏
bbc.com/news/articles/cpv4jw…
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5 Mar 2025
🚨Paper alert 🚨 Our latest research is out in @Nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ @WeizmannScience @Sys_Immunology
🔗 nature.com/articles/s41586-0…
🧵👇
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5 Mar 2025
4/ We hope these findings contribute to a better understanding of innate immunity, and open up exciting possibilities for developing new therapeutic strategies against infections, particularly in the face of rising antibiotic resistance.🔬✨
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5 Mar 2025
5/ This discovery was led by the incredible @KarinGoldberg5 and the amazing support of other team members - highlighting the meaning of teamwork. A huge shoutout to our fantastic collaborators Gee W. Lau, Nissan Yissachar, and Zvi Hayouka.
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20 Jan 2025
1/14 Excited to share our new @Elinav_Lab @Elinav_DKFZ @WeizmannScience paper @CellCellPress, championed (for 6 years!) by the amazing @rvaldesmas, @AvnerLeshem, @DanpingZheng and twitter-less Alon Savidor. In this work, we’ve adopted into microbiome.. cell.com/cell/fulltext/S0092…
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2 Oct 2024
Congratulations to the Poster Award winners #EMBOubiquitin24: Jason Collins from @werner_achim Kai Gallant from @MalteGersch and Chatrin Chatrin from @IvanAhelLab
Well done! 👏💫🏆 @YKulathu @polosimona1 @LabJoazeiro
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1 Oct 2024
it’s a wrap- thank you all 🙏 Such high energies following a meeting with great science, amazing people and beautiful views 🤩🥂💃🕺💫#EMBOubiquitin24
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Yifat Merbl lab retweeted
1 Oct 2024
Fascinating talk by Andrea Murachelli who defined a structure of BRCA1-A with a novel metallo-DUB Inhibitor #EMBOubiquitin24
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Yifat Merbl lab retweeted
1 Oct 2024
We started the last session on UPS therapeutics with a great talk by Stefan Müller @IBC2_GU on SUMO-UB network in stress mediated aggregation #EMBOubiquitin24
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