@TriIMDPhD @junyue_cao lab @RockefellerUniv @WeillCornell (views are my own) Previously @broadinstitute @RutgersU-B.A
Joined March 2020
- Tweets 1,118
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- Followers 607
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15 Photos and videos
Pinned Tweet
May 12
Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$.
With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s41593-0…
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AbdulAbdul retweeted
Jun 12
Our CytoSignal paper is now published in @NatureGenet! During revision, we generated a one-of-a-kind dataset with direct measurements of ligand-receptor protein interactions in situ in the mouse embryo, along with Visium HD spatial transcriptomics. nature.com/articles/s41588-0…
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How can you use RNA velocity to infer the dynamics of cell signaling from spatial transcriptomic data? Check out our new preprint!
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AbdulAbdul retweeted
I’m delighted to finally share work from my PhD with @dalygene and @s_mccarroll.
We show how human genetics and AlphaFold3-predicted protein structure can be combined to discover new mechanisms underlying missense risk in brain disorders.
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biorxiv.org/content/10.1101/…
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AbdulAbdul retweeted
Delighted to share our new preprint on xVDM (cross-linked volumetric DNA microscopy), turning the protein scaffolds inside intact tissue into dense, DNA-encoded proximity networks for transcriptome and protein mapping.
biorxiv.org/content/10.64898…
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Jun 4
Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
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Jun 4
Congrats @xu_zxu and Aileen on this amazing work!
Thank you so much Jun! This was a great team effort with the brilliant but Twitterless Aileen, an MD-PhD student in the @junyue_cao Lab. It has been such a privilege to work with everyone in the lab and to call @RockefellerUniv my PhD home.
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Jun 3
New preprint alert! 🚀 Across 60 human cancer cell lines spanning 20 cancer types, single-cell RNA ATAC reveals pan-cancer cell-state heterogeneity, core gene-regulatory networks, and an EMT axis conserved across tissue origins.
Huge congrats to first author @xu_zxu, who recently defended his PhD, and Aileen Ugurbil from our lab @RockefellerUniv! biorxiv.org/cgi/content/shor…
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Jun 2
New preprint alert🚀 Using TrackerSci, we quantified the birth rate of each cell type across the whole organism, and how these rates are rewired with age.
Huge congrats to the incredible Dr. Lu @ziyu__lu from @RockefellerUniv, who just defended today!
biorxiv.org/content/10.64898…
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Today at #ASCO26, more results about the newest clinical trial of daraxonrasib: In the Phase III RASolute-302 trial, a once-daily RAS(ON) inhibitor nearly doubled median overall survival (13.2 vs 6.7 months) and reduced the risk of death by ~60% versus chemotherapy in previously treated metastatic pancreatic cancer.
KRAS was once considered “undruggable.” This is what persistence in science looks like.
A landmark moment for targeted therapy and for patients who desperately need better options. #CancerResearch #PancreaticCancer
Pancreatic cancer has one of the most suppressive tumor microenvironments in oncology.
But two pancreatic cancer results dropped today. Both matter.
1. BioNTech mRNA neoantigen vaccine: nearly all responders still alive at 6 years. 98% of induced T cells were de novo — the immune system learned to see a cancer it had always been blind to.
2. Daraxonrasib: 47% ORR, 92% disease control as first-line monotherapy. KRAS G12D, undruggable for 40 years, finally has a drug.
Different mechanisms. Same disease. Both working.
<13% of patients survive 5 years. That number is about to change.
great day for science! 🔥
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AbdulAbdul retweeted
May 31
There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicines
nejm.org/doi/full/10.1056/NE…
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May 27
Cardiac "remuscularization" for treating severe heart failure with patched heart muscle derived from stem cells (a biological ventricular assist device) successful in 12 of 20 patients @NEJM
nejm.org/doi/full/10.1056/NE… nejm.org/doi/full/10.1056/NE…
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AbdulAbdul retweeted
May 16
lymphocyteが脳老化に於る炎症と脳室恒常性を制御
IRISeqは光学撮像不要のビーズ間配列決定で脳組織を空間的にprofiling
老齢mouse脳で脳室IFN炎症をlymphocyteが駆動しlymphocyte欠損が上衣細胞を保護する新機序を解明
OA
#aging
#immunology
#papers
nature.com/articles/s41593-0…
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AbdulAbdul retweeted
Long-term editing of brain circuits with engineered electrical synapses! I still remember years ago when @KafuiDzirasa from @DukeU @hhmi_science called me beaming with excitement about this new technology. Here it is today @Nature.
nature.com/articles/s41586-0…
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May 12
Our scalable, cost-effective, and optics-free spatial genomic technique, IRISeq, is out in Nature Neuroscience today! Congrats to incredible @Abdul_Squared and @Weirong_Jiang from our lab at @RockefellerUniv
May 12
Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$.
With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s41593-0…
16
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May 12
Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$.
With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s41593-0…
5
37
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30,935
May 12
explore how lymphocytes depletion modulates brainwide interferon-associated signatures in aging.
This work would not be possible without my amazing mentors @junyue_cao and @Wei_Zhou_1989 , whose unwavering support made this work possible. Also incredibly grateful to have worked
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May 12
alongside my partner in crime @Weirong_Jiang , and the rest of our awesome collaborators @xu_zxu and @Tommyz626 , and the rest of the team.
Very grateful to @NatureNeuro, the reviewers, and Dr. @RongFan8 for helping us improve the work through their deeply insightful comments.
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Excited to see this in print! Kudos to Haikuo, Bo, and the entire team including @MinaXu7 @yalepathology @zhou_jingtian @arcinstitute to explore this clinically relevant area of lymphoma transformation with truly innovative technology. @theNCI #HTAN
nature.com/articles/s41467-0…
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AbdulAbdul retweeted
I don’t post much anymore but thought I would take a moment to share my feelings on an issue that has been papered over by the negative impact that external forces have had on science and scientists: the toxicity of our own interactions within the scientific community. (1/10)
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AbdulAbdul retweeted
Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
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