The ancient Greeks made a psychedelic from toxic fungus, wood ash, & water — and served it to thousands every year for 2,000 years. A paper published today in Nature showed how. Plato drank this. Cicero drank this. The Western world was built on a psychedelic sacrament.

NEW: U.K. advances proposal to force Apple, Google, Signal, & other platforms to scan private content on users’ devices — executives could face prison if they refuse.

Terrence McKenna decades ago…

Apparently ~160 people in Austin, TX may make $100M from the SpaceX IPO. 12 will clear $1B. Don't sleep on Austin - that's a lot of capital formation, very quickly.

NEWS: OpenAI just announced that it has officially closed their latest funding round with $122 billion in committed capital at a post money valuation of $852 billion. "We are now generating $2B in revenue per month. At this stage, we are growing revenue four times faster than the companies who defined the Internet and mobile eras, including Alphabet and Meta. ChatGPT has more than 900 million weekly active users, and over 50 million subscribers. Search usage has nearly tripled in a year, and our ads pilot reached more than $100 million in ARR in under six weeks. Momentum is just as strong on the enterprise side, which now makes up more than 40% of our revenue, and is on track to reach parity with consumer by the end of 2026. GPT‑5.4 is driving record engagement across agentic workflows. Our APIs now process more than 15 billion tokens per minute. Codex now serves over 2 million weekly users, up 5x in the past three months, with usage growing more than 70% month over month."

Let’s go Team Austin! @MichaelDell @elonmusk @davidsacks47 @JoshuaBaer @JTLonsdale @travisk @williampbarnes @amandabradford @fordsmith @JacqKD @lons @twistartups @tedcruz @GregAbbott_TX 🐎

Investment in Austin-based startups grew to a record high of $7.19B in 2025, up from $4.37B in 2024 and topping a pandemic peak of $6.1B in 2021 (@bayareawriter / Crunchbase News) news.crunchbase.com/venture/… techmeme.com/260328/p2#a2603… 📥 Send tips! techmeme.com/contact

"We exist in an environment that systematically outputs unhealthy people." @truemed CEO Justin Mares joins a16z's Erik Torenberg to trace the roots of America's chronic disease crisis – and what it would take to fix it: - How $100 billion is subsidizing the ingredients making us sick - The case against universal Ozempic - The many chemical compounds allowed in the US but banned in Europe - Why peptides could be "exceptionally disruptive" to pharma - The Ray Peat view: more sugar, more metabolism, more energy 00:00 Introduction 0:44 The environment that makes us sick 04:19 What went wrong in the 1970s 6:10 The subsidy problem 8:49 Universal Ozempic won't save us 12:21 Building Truemed 15:59 The zoo animal theory of human health 18:33 The chronic disease crisis as a matter of national security 27:52 Psychedelics as mental health therapy 35:49 Why peptides will disrupt pharma @jwmares @eriktorenberg

Can't imagine a software company saying they deserve your discoveries because you used their software. Ads were inevitable, but this sounds wild.

Quality of life improvement

🚨PESTICIDE IMMUNITY EMERGENCY!!!🚨 WHILE YOU WERE WITH FAMILY OVER THE HOLIDAYS, CONGRESS MOVED TO PROTECT PESTICIDE COMPANIES FROM CANCER AND OTHER LAWSUITS. Reshare this now! Congress is quietly sneaking Section 453 into the spending bill— and Republicans like @CongMikeSimpson @lisamurkowski @SpeakerJohnson are helping pesticide giants dodge liability. Section 453 gives legal immunity to chemical companies—even if their product harms your kids. @CongMikeSimpson calls it a “labeling clarification.” That’s a lie. It’s a free pass for Bayer, Syngenta, and every foreign manufacturer dumping poison on U.S. soil. If this passes, you won’t be able to sue—even if you’re harmed. NO MORE IMMUNITY FOR CORPORATE POISON. Kill Section 453!!! SAVE OUR FARMERS!!! @HouseAppropsGOP *Thanks @amtoxicology for keeping this on our radar!

Robots have become so accurate that they can carry out surgery on an egg without breaking it.

Elon Musk should just go ahead and merge SpaceX, Tesla, and xAI. We all know it makes sense for him to do it. Give the world a single stock ticker to bet on the future of abundance.