New study in @NatureMedicine from @skopetz@MDAndersonNews and colleagues
Molecular profiling of BRAF-V600E-mutant metastatic colorectal cancer in the phase 3 BEACON CRC trial
nature.com/articles/s41591-0…
The putative genomic mechanisms of resistance (on ctDNA) illustrated below (~60% of patients, highlighting how selective treatment pressure drives these resistance related secondary alterations).
🚨 We are hiring! Gd 7 PDRA position to support research on new AI-based classifiers of RT response in #rectalcancer👇
my.corehr.com/pls/uogrecruit…
Funded by Stand Up to Cancer campaign for CRUK - please get in touch!
🚨 #PRODIGE44 - preop radiation for LA-BR-PDAC
Phase 2 of👥110 pts
Preop mFOLFIRINOX rads🆚no rads
❌No difference R0
❌No difference OS or PFS
#ESMO24 really hitting nail in⚰️of neoadj rads in GI cancers
🎉Great news: close 50 months median OS with resection after NAT!
🚨🚨Hot off the press @NEJM
In a randomized Ph II Ponsegromab, an anti-GDF15 mAB, increased weight gain, overall physical activity and reduced cachexia symptoms in patients with #cachexia and ⬆️ GDF-15
nejm.org/doi/full/10.1056/NE…
Enticing results reported in the TORCH study at #ASCO24 and just published in @JCO_ASCO
📢#Immunotherapy with chemotherapy (iTNT) in rectal cancer associated with complete response rates of 56.5% in group A and 54.2% in group B
Full paper 🔗: ascopubs.org/doi/abs/10.1200…
Those who saw the BBC article about our paper will have seen Lauren Golightly explain what life with Crohn's is like for her. Lauren is not just an great advocate but also a trainee psychologist - if you have IBD please spare 5min to fill in her survey about mental health in IBD:
Technicians are the backbone of innovation, turning ideas into reality, one experiment at a time. Keep pushing boundaries and inspiring change.
Our Technicians had great time attending the @UofGTechnicians@TechsCommit Conference @UofGlasgow ! 🌟 #Networking#CPD#Technician🔬🧪
Not just IBD though - similar changes were found in #PSC (a liver disease) for which there are no treatments currently. Kudos to the amazing teams @nanostringtech and @nigeljamieson lab in Glasgow for help with this
Ecstatic and proud to share the NICHE-2 results, now published in @NEJM. Out of 111 pts, 95% had an MPR , and 68% a pCR after only 4 weeks of #neoadjuvant#immunotherapy. Grateful to the pts and colleagues who made this possible. @HaanenJohnnej.md/3Ku4X0H
🆕 Receiving an epidural during labour is associated with a significant reduction in severe maternal morbidity (serious health problems during childbirth or the six weeks following birth), according to new UofG research.
More ➡️ gla.ac/44R4NKj