𝗧𝗵𝗲 𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗣𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺 𝗶𝘀 𝗰𝗼𝗺𝗶𝗻𝗴 𝘁𝗼 𝗧𝗼𝗸𝘆𝗼 𝘁𝗵𝗶𝘀 𝗝𝘂𝗹𝘆! Following the success of the two editions of the Membrane Physiology Symposiums in California, we’re excited to bring the series to Japan for the very first time! 📅 July 17–18, 2025 📌 University of Tokyo, RCAST Komaba Campus 🎟 Admission: Free This two-day event will gather leading voices in membrane physiology, ion channels, membrane proteins, and regenerative medicine, across academia, biotech, and pharma, to exchange ideas, share breakthroughs, and foster collaboration. Meet the speakers: Dr. Takeshi Akiyoshi, Dr. Shin Hamamoto, Dr. Shutaro Katsurabayashi, Dr. Hideaki Kato, Dr. Tomoya Kubota, Dr. Yuichiro Miyaoka, Dr. Chai Ann (Andy) Ng, Dr. Alexandre SANTINHO, Dr. Will Seibertz, and Martin Ziller. We’re proud to continue this global symposium series and can't wait to connect with the Japanese research community. 📝 𝗣𝗿𝗼𝗴𝗿𝗮𝗺, 𝘀𝗽𝗲𝗮𝗸𝗲𝗿𝘀 & 𝗿𝗲𝗴𝗶𝘀𝘁𝗿𝗮𝘁𝗶𝗼𝗻: ow.ly/2bpT50Wbn0E #MembranePhysiology #MPSJapan2025 #Electrophysiology #IonChannels #MembraneProteins #CellAnalytics

𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘁 𝗕𝗣𝗦 𝟮𝟬𝟮𝟱 – 𝗘𝘅𝗽𝗹𝗼𝗿𝗲 𝗼𝘂𝗿 𝗹𝗮𝘁𝗲𝘀𝘁 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵! We’re excited to present six scientific posters at the Biophysical Society Annual Meeting 2025 in Los Angeles! Our team will showcase cutting-edge research on ion channels, membrane transporters, GPCRs, and more. 📍Where? West Exhibit Hall 📅 When? February 16–18, 2025 𝗦𝘂𝗻𝗱𝗮𝘆, 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 𝟭𝟲 ▪️Light-induced action potentials and STEM-cell derived sensory neurons: An automated patch clamp investigation - Presenting: Ali Obergrussberger ▪️Block of voltage- and ligand-gated ion channels by toxins using automated patch clamp - A detection tool? - Presenting: Ali Obergrussberger ▪️Profiling the pharmacology of GPCRs by time-resolved impedance measurements - Presenting: Ronald J Knox 𝗠𝗼𝗻𝗱𝗮𝘆, 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 𝟭𝟳 ▪️ Functional characterization of lysosomal channels TMEM175 and TPC2 using solid supported membrane-based electrophysiology - Presenting: Rocco Zerlotti ▪️ Investigating the effect of temperature and trafficking modulators on hERG current using high-throughput automated patch clamp - Presenting: Søren Friis 𝗧𝘂𝗲𝘀𝗱𝗮𝘆, 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 𝟭𝟴 ▪️ Quantitative and mechanistic analysis of protein membrane pore formation on a high-throughput electrophysiology platform - Presenting: Tobias Ensslen Attending hashtag#BPS2025? Stop by our posters to discuss the latest in ion channel research, electrophysiology, and new assay developments. 📍𝗩𝗶𝘀𝗶𝘁 𝘂𝘀 𝗮𝘁 𝗕𝗼𝗼𝘁𝗵 #𝟱𝟬𝟵! Find more details about our posters here: ow.ly/SzmM50UR5sP #Biophysics #Electrophysiology #IonChannels #GPCR #BPS2025 #DrugDiscovery #APC #CellAnalytics #MembraneBiophysics

𝗔𝗿𝗲 𝘆𝗼𝘂 𝗶𝗻𝘁𝗼 𝗶𝗼𝗻 𝗰𝗵𝗮𝗻𝗻𝗲𝗹𝘀 𝗮𝗻𝗱 𝗰𝘂𝗿𝗶𝗼𝘂𝘀 𝗮𝗯𝗼𝘂𝘁 𝗻𝗲𝘄 𝘁𝗼𝗼𝗹𝘀 𝗮𝗻𝗱 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵𝗲𝘀 𝘁𝗼 𝘀𝘁𝘂𝗱𝘆 𝘁𝗵𝗲𝗺? We offer hands-on workshops and instrument demos to help researchers explore new methods and technologies. Our sessions are simple, practical, and include live demonstrations of tools like the 𝗣𝗼𝗿𝘁-𝗮-𝗣𝗮𝘁𝗰𝗵 or the 𝗢𝗿𝗯𝗶𝘁 𝗠𝗶𝗻𝗶. Whether you’re just starting out or looking to optimize your experiments, send us a message, and we’ll organize a session that works for you. ➡️Contact us here: ow.ly/X9fm50UhwuP #IonChannelResearch #HandsOnWorkshops #PatchClamp #Electrophysiology #AcademicResearch #DrugDiscovery #APC #MembraneBiophysics #CellAnalytics

Post-acute sequelae of COVID-19 (PASC) affects an estimated 65 million people globally, with many experiencing cardiovascular symptoms (CVS) that persist long after the initial infection. The cause of PASC-CVS remains elusive, but growing evidence suggests a link to chronic inflammation. A recent study, published in Nature Microbiology, investigated the role of chronic inflammation in PASC-CVS and its potential impact on cardiovascular function. Researchers assessed trace-level pro-inflammatory cytokines in individuals with PASC-CVS who reported symptoms such as chest pain and heart palpitations persisting over a year post-infection. Using advanced nanotechnology, the team identified minute levels of cytokines (IL-1β, IL-6, IL-12, and MCP-1) in plasma samples collected 18 months after infection—levels often undetectable by conventional assays. To explore this further, the researchers employed a combination of proteomic and transcriptomic approaches alongside functional assays on primary human cardiomyocytes, utilizing the CardioExcyte 96 system. They demonstrated that these trace cytokine levels reduced cardiomyocyte contractility and altered relaxation dynamics, suggesting a direct link between inflammation and cardiovascular symptoms. Proteomic analysis also revealed elevated levels of complement and coagulation-related proteins in PASC-CVS plasma, supporting the hypothesis of chronic inflammation-driven microclotting in these patients. These findings provide crucial insights into the mechanisms underlying PASC-CVS and underscore the potential role of chronic inflammation in driving persistent cardiovascular symptoms in COVID-19 survivors. The study's results suggest that even low levels of inflammatory mediators can have significant physiological effects, potentially explaining the ongoing symptoms experienced by PASC-CVS patients. -- Find the full article here: nature.com/articles/s41564-0… Learn more about the CardioExcyte 96, a turn-key system for efficient impedance and extracellular field potential measurements: nanion.de/products/cardioexc… #covid #sarscov2 #impedance #cellanalytics #heart

𝗧𝗵𝗲 𝗡𝗮𝗻𝗶𝗼𝗻 𝗨𝘀𝗲𝗿 𝗠𝗲𝗲𝘁𝗶𝗻𝗴 𝟮𝟬𝟮𝟰 𝗶𝘀 𝘂𝗻𝗱𝗲𝗿𝘄𝗮𝘆! 🎉 We’ve just kicked off with an exciting 2-hour 𝗦𝘆𝗻𝗰𝗿𝗼𝗣𝗮𝘁𝗰𝗵 𝟯𝟴𝟰 𝗪𝗼𝗿𝗸𝘀𝗵𝗼𝗽! The main event, featuring insightful talks, begins in just 2 hours, starting with a welcome from Niels Fertig. Whether you're already here at our Munich HQ or joining us virtually, there’s plenty more to come – don’t miss out on expert presentations and engaging discussions! Join us at 𝟭𝟯:𝟬𝟬 𝗖𝗘𝗦𝗧 for the official start of the event! We’re excited to see you soon! #NanionUserMeeting #Electrophysiology #APC #MembraneBiophysics #CellAnalytics

𝗜𝗻𝘃𝗲𝘀𝘁𝗶𝗴𝗮𝘁𝗶𝗻𝗴 𝗚𝗣𝗖𝗥𝘀 𝘄𝗶𝘁𝗵 𝗘𝗹𝗲𝗰𝘁𝗿𝗶𝗰𝗮𝗹 𝗜𝗺𝗽𝗲𝗱𝗮𝗻𝗰𝗲 𝗦𝗽𝗲𝗰𝘁𝗿𝗼𝘀𝗰𝗼𝗽𝘆 (𝗘𝗜𝗦) G protein-coupled receptor (GPCR) activation triggers complex cellular responses that are key for drug discovery and development. One critical outcome of GPCR stimulation is the morphological transformation of cells, which can include changes in size, shape, and internal structure. These cellular rearrangements directly impact the electrical properties of the cell. Electrical impedance spectroscopy (EIS) is the ideal method to quantify these electrical shifts, providing a powerful, unbiased approach to study GPCR pathways. Why EIS and AtlaZ are game-changers for GPCR research? EIS measurements come with several unique advantages that elevate GPCR research, including real-time kinetic analysis of cellular responses in both agonist and antagonist modes. The AtlaZ system further enhances GPCR investigation by offering: ✔️ Exceptional time resolution to capture fast cellular dynamics. ✔️ High-throughput capabilities for efficient data generation. ✔️ A label-free process that preserves cellular integrity. ✔️ No need for genetic modifications, making the assay simpler and faster. ✔️ Multi-frequency measurements that allow pinpointing the most sensitive frequency for each cell type, making it sensitive enough for endogenously expressed receptors. Each GPCR-induced cellular response may manifest at distinct frequencies, and AtlaZ makes it easy to identify the ideal frequency for clear, reliable results. Curious to know more? Discover more about AtlaZ and EIS for GPCR research in our latest technical note: ow.ly/f5ws50TyGSW #Impedance #CellAnalytics #AtlaZ #GPCRs #GPCRResearch #CellMonitoring #Kinetics #LabelFree #RealTime

𝗧𝗿𝗮𝗻𝘀𝗳𝗼𝗿𝗺𝗶𝗻𝗴 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝘄𝗶𝘁𝗵 𝗖𝗮𝗿𝗱𝗶𝗼𝘀𝗶𝗴𝗵𝘁®-𝗦 𝗮𝗻𝗱 𝗖𝗮𝗿𝗱𝗶𝗼𝗘𝘅𝗰𝘆𝘁𝗲 𝟵𝟲 Animal models often fail to accurately predict how human heart cells respond to new compounds due to differences between species. This highlights the urgent need for better models in drug testing. With NEXEL´s Cardiosight®-S human heart cells and the CardioExcyte 96 system, you gain access to reliable data that replaces animal testing and enhances the accuracy of drug-induced heart function studies. Our latest application note showcases this powerful combination, offering detailed guidance on compound treatment, data acquisition, and analysis. Key insights: ◾ Simultaneous measurement of both ion channel activity (EFP) and contractility (IMP) ◾ Dose-dependent effects of Nifedipine on beat rate and contractile force ◾ Non-invasive, label-free monitoring for long-term, high-resolution data Want to bring greater precision and predictability to your cardiac research? 📊 Explore the application note for valuable insights. Read more here: ow.ly/Tgpo50TqHI2 #CardiacResearch #DrugDiscovery #hiPSC #Cardiomyocytes #CardioExcyte96 #CellAnalytics

𝗡𝗮𝗻𝗶𝗼𝗻 𝗨𝘀𝗲𝗿 𝗠𝗲𝗲𝘁𝗶𝗻𝗴 𝟮𝟬𝟮𝟰 - 𝗔𝗴𝗲𝗻𝗱𝗮 𝗶𝘀 𝗻𝗼𝘄 𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗹𝗲! Join us on October 22-23 at Nanion Technologies HQ in Munich for two days of insightful talks, interactive poster sessions, and instrument demos showcasing new applications and product highlights. We’ve got an exciting lineup of speakers from around the world, eager to share their latest research and innovations. Whether you're focused on assay development, advancing cardiac safety, exploring ion channels and membrane transporters, or diving into the latest trends in drug discovery, at our user meeting there's something for everyone: ✅ Engage with experts ✅ Explore cutting-edge applications ✅ See our products in action ✅ Build connections Curious about the speakers and sessions? Check out the full agenda and secure your spot today: ow.ly/E6g950T39ft #UserMeeting #NUM2024 #Event #APC #CellAnalytics #MembraneBiophysics #ScientificConference

𝗘𝗻𝗵𝗮𝗻𝗰𝗶𝗻𝗴 𝗵𝗶𝗣𝗦𝗖-𝗖𝗠 𝗺𝗮𝘁𝘂𝗿𝗮𝘁𝗶𝗼𝗻 𝘄𝗶𝘁𝗵 𝗧𝟯 𝗮𝗻𝗱 𝗗𝗲𝘅: 𝗔 𝗺𝘂𝗹𝘁𝗶𝗽𝗹𝗲𝘅 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵 🫀✨ Are you working with hiPSC-derived cardiomyocytes (hiPSC-CMs) and looking to improve their maturation for applications in disease modeling, drug discovery, or cell therapy? We've got something exciting to share with you! In collaboration with Bayer, Fraunhofer IBMT, and Hamamatsu Photonics France, we've developed an application note that dives into how triiodothyronine (T3) and dexamethasone (Dex) can enhance the structural and functional maturation of hiPSC-CMs. Our study combines impedance/EFP and calcium imaging to track calcium transients and electrical activity in the same cells. The results are promising, T3 and Dex not only modulate the electrical activity but also improve calcium handling, crucial for the maturation of these cells. We also explored how the NSP-96 transparent plate can be used for multiple assays, allowing you to measure electrical activity, contractility, and calcium transients from the same cell population using the CardioExcyte 96 and FDSS/μCELL. This means more data from fewer cells and reduced variability. Curious to learn more? Check out the full application note here: ow.ly/bwVS50T1NC4 #Cardiomyocytes #hiPSC #StemCells #DrugDiscovery #CellAnalytics #CardioExcyte96

𝗜𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝗰𝗲 𝗼𝗳 𝗰𝗲𝗹𝗹 𝗺𝗼𝗱𝗲𝗹𝘀 𝗶𝗻 𝗽𝗿𝗲𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 🧬🔬 As biomedical research advances, cell models are transforming the landscape, guiding us towards more ethical and precise science. Moving beyond the traditional animal models, 2D and 3D cell models have become indispensable tools, offering reliable alternatives paving the way for personalized medicine. Innovations like CRISPR and induced pluripotent stem cells (iPSCs) have revolutionized our ability to study human diseases in a dish. Human iPSCs, in particular, are a game changer, offering a viable alternative to primary cells. They replicate native cell behavior, are available in large quantities, and are of human origin. Our cutting-edge platforms for automated patch clamp, cell analytics, and membrane biophysics are at the forefront of research and drug discovery. Our systems allow researchers to screen ion channels with unmatched flexibility and scalability, explore complex cellular behaviors, and study membrane dynamics with precision and depth. 🔍 Curious to learn more? Explore our iPSC profiling solutions: ow.ly/gee350T11PJ #iPSC #CellModels #CellAnalytics #Electrophysiology #PatchClamp #APC #MembraneBiophysics

𝗗𝗿𝘂𝗴 𝗗𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆: 𝗙𝗿𝗼𝗺 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗲𝘀 𝘁𝗼 𝗺𝗲𝗱𝗶𝗰𝗶𝗻𝗲 The journey from a promising molecule to an approved medicine is long and complex, often taking 12-15 years. This process involves key stages like target identification, compound screening, lead optimization, and clinical trials. New small molecules are typically identified by high throughput screening (HTS) of large libraries containing millions of compounds, with hit compounds optimized by medicinal chemistry methods. Today, AI, machine learning, and human iPSCs are transforming drug discovery, making it more precise and paving the way for personalized medicine. Therefore, integrating advanced technologies—like single channel recordings, automated patch clamp, and transporter assays—can significantly speed up drug development, reducing time and costs. In a rapidly evolving landscape, implementing these tools is essential for driving innovation in drug development. At Nanion, we provide outstanding instrumentation and expertise to advance scientific development, drug discovery and ultimately improve lives. Ready to take your drug discovery to the next level? ➡️ Explore our cutting-edge instrumentation for all phases of drug development: ow.ly/9oHG50SUEa8 #APC #MembraneBiophysics #CellAnalytics #DrugDiscovery #DrugDevelopment #ClinicalTrials #HighThroughput

𝗠𝗮𝗿𝗸 𝘆𝗼𝘂𝗿 𝗰𝗮𝗹𝗲𝗻𝗱𝗮𝗿𝘀 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗡𝗮𝗻𝗶𝗼𝗻 𝗨𝘀𝗲𝗿 𝗠𝗲𝗲𝘁𝗶𝗻𝗴 𝟮𝟬𝟮𝟰 When: October 22-23, 2024 📅 Where: Nanion Headquarters in Munich & online📍 The Nanion User Meeting is a platform for sharing and learning from the experts and peers in the fields of drug discovery, assay development, cardiac safety, ion channels and transporters, automated patch clamp, membrane biophysics, cell analytics, and beyond. Whether you join us in person at the Nanion HQ in Munich, or virtually from anywhere in the world, you will enjoy 2 days of amazing talks, product demos, posters, networking, and much more! Secure your spot now! Register here: ow.ly/bwis50QIPbA #UserMeeting #NUM #Event #APC #CellAnalytics #MembraneBiophysics

𝗧𝗵𝗲 𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗣𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺 𝟮𝟬𝟮𝟰 𝗶𝗻 𝗡𝗮𝗽𝗮 𝗩𝗮𝗹𝗹𝗲𝘆 𝘀𝘁𝗮𝗿𝘁𝘀 𝗼𝗻 𝗠𝗼𝗻𝗱𝗮𝘆! 🌄 The countdown is on! In less than a week, we’ll be gathering at the breathtaking Napa Valley for the Membrane Physiology Symposium 2024. If you’re passionate about ion channels, transporters, and cell physiology, this symposium is a must-attend event. 🗓️ When: April 22-23rd, 2024 📍 Where: Meritage Resort and Spa, 875 Bordeaux Way, Napa, CA 94558, United States Here’s what awaits you: ▪️ 𝗖𝘂𝘁𝘁𝗶𝗻𝗴-𝗘𝗱𝗴𝗲 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀: Immerse yourself in an enriching program featuring established leaders in these fields. ▪️ 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝗶𝗻𝗴 𝗶𝗻 𝗣𝗮𝗿𝗮𝗱𝗶𝘀𝗲: Connect with peers, exchange ideas, and forge lasting collaborations surrounded by vineyards and rolling hills. ▪️ 𝗘𝘅𝗰𝗹𝘂𝘀𝗶𝘃𝗲 𝗪𝗶𝗻𝗲 𝗧𝗮𝘀𝘁𝗶𝗻𝗴: Thanks to our sponsor, SB Drug Discovery, you’ll have the chance to savor the finest wines the region has to offer. Don’t miss this delightful experience! 🔗 Explore the Full Program. Dive into the exciting sessions, talks and activities lined up for you. Learn more here: nanion.de/membrane-physiolog… 🙏 Acknowledging Our Sponsors: A heartfelt thank you to SB Drug Discovery, @OmniAbTech, @AnatomicTech, @AxolBio, @MaxCyte_info, ION Biosciences, @CellDynamics, and IONTX Inc. Your support makes this event possible! Get ready for Days of science and wine in the heart of Napa Valley. 🍇🔬 #MembranePhysiologySymposium #MPS #IonChannels #Electrophysiology #Transporters #APC #MembraneBiophysics #CellAnalytics #Physiology #Biophysics

𝗡𝗶𝗰𝗲 𝗺𝗲𝗲𝘁𝗶𝗻𝗴 𝘆𝗼𝘂 – Amazing time at 38th Microelectrode Techniques for Cell Physiology Workshop! We had so much fun at the Workshop, where students learned how to patch a cell and got their first #patchclamp recordings after just 10 minutes of training with beautiful currents. Thank you all for the great reception and interest in the workshop. Nanion is proud to have sponsored the student's bursary and, thus, contribute to the academic development of students who will be the researchers leading the science of tomorrow. If you would like to know more about Nanion, and the solutions we offer for Automated Patch Clamp, visit: ow.ly/9oKI50PIgyG #Electrophysiology #Ionchannels #Physiology #Workshop #AutomatedPatchClamp #MembraneBiophysics #CellAnalytics

🔬 Discover SnapCyte: Your Cell Analytics Gateway! 🚀 ✨ Upgrade your microscope with SnapCyte™ App. 📱💡 🔎 Snap, check, and know cell confluency in seconds using AI. 📸💪 Join SnapCyte today! ✨🌍 #biotech #AI #lifescience #biology #CellAnalytics #Breakthrough

47th Annual Meeting of the ESC Working Group on Cardiac and Cellular Electrophysiology Join us to learn more about our #CellAnalytics and #APC platforms offering sophisticated solutions for #cardiacresearch Find more information about this symposium here: ow.ly/Y7HB50OFu8M

𝗛𝗮𝗽𝗽𝘆 𝗜𝗻𝘁𝗲𝗿𝗻𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝘄𝗼𝗺𝗲𝗻´𝘀 𝗱𝗮𝘆! At Nanion we honor, celebrate, and empower the women on our team. Meet the women behind #teamNanion by visiting our new website here: bit.ly/3ysq90V #automatedpatchclamp #membranebiophysics #cellanalytics

Cytomos has been shortlisted as Finalist for the SME of the Year category of the Midlothian & East Lothian Business Awards/ Read the full announcement here: linkedin.com/feed/update/urn… #award #cytomos #growth #business #PAT #cellanalytics

Qué esperar de la cobertura móvil en los puntos de interés más concurridos de Barcelona durante el #MWC22 Un estudio de #Ookla con datos de #CellAnalytics muestra qué operadores españoles tienen la mejor intensidad de señal en puntos de referencia. laecuaciondigital.com/actual…