🔬👏 We are pleased to share that
@GEICAM is contributing to
#AACR26 (Annual Meeting of the
@AACR) with two communications in which we have actively collaborated.
🌍 This congress represents a key meeting point for the global
#cancerresearch community, bringing together scientists, clinicians, and healthcare professionals to present the latest advances across the full spectrum of
#cancer research, from prevention to clinical studies and survivorship.
🧬 One of these contributions is the
#CONFLUENCE project, presented as a mini-oral in which GEICAM contributes with biological samples and clinical data from patients included in three GEICAM studies: GEICAM 2017/07 EMBARCAM (415 patients), epiGEICAM (865 patients and 834 healthy controls) and the GEICAM 2016/04_Male Breast Cancer Registry (181 patients and 109 healthy controls).
🤝 The CONFLUENCE project is a large international collaboration coordinated by the National Cancer Institute (
@theNCI) involving multiple
#breastcancer consortia, biobanks, and individual research studies, studying breast cancer in females, males, and carriers of breast cancer susceptibility genes. It is focused in building a large
#research resource to uncover breast cancer genetics through genome-wide association studies (GWAS) in diverse populations.
📝 This ambitious international initiative represents the largest multi-ancestry GWAS in breast cancer to date: with around 290
#studies from 61 countries, CONFLUENCE includes over 400,000 breast cancer cases and 1,700,000 controls, nearly tripling the effective sample size of previous GWAS and substantially increasing sample diversity across multiple ancestries, including non- European.
🔍 The CONFLUENCE project has identified 545 independent susceptibility loci (from which 273 are novel), substantially expanding explained
#genetic risk across ancestry groups and building a new Polygenic Risk Score (PRS) that has outperformed the established 313-variant PRS.
🙌 This international effort marks a major step forward in understanding the genetic basis of the disease, improving prevention strategies, and moving towards more precise and personalized diagnosis for breast cancer
#patients worldwide.
💜 We are proud to be part of such a landmark project and to contribute to its impact within the global research community!
🤓 More information about the
#ConfluenceProject can be found here:
➡️
dceg.cancer.gov/research/can…