. ​— Alireza (Alex) ​hashtag#ArtificialIntelligence hashtag#CRISPR hashtag#mRNA hashtag#Biotech hashtag#Longevity hashtag#FutureOfTech hashtag#DNAEngineering hashtag#Innovation

Biotechnology Engineering is where biology meets technology to shape the future, From genetic engineering to large-scale bioprocesses, it powers innovations in healthcare, agriculture, and industry, turning cells, genes, and microbes into life-saving solutions. This is science that doesn’t just study life, it engineers it. #BiotechnologyEngineering #Biotech #GeneticEngineering #BioprocessEngineering #DNAEngineering #LifeSciences #BiotechInnovation #FutureOfScience #STEM #Bioengineering #MedicalBiotechnology #IndustrialBiotech #ScienceExplained #BiologyMeetsTechnology

Gumbel-Softmax Flow Matching with Straight-Through Guidance for Controllable Biological Sequence Generation 1. This paper introduces Gumbel-Softmax Flow Matching, a novel generative framework designed for controllable biological sequence generation. It addresses the limitations of previous discrete simplex-based models by leveraging a Gumbel-Softmax interpolant with time-dependent temperature modulation. 2. The method defines a new velocity field that smoothly transports noisy categorical distributions to clean, discrete sequences on the simplex. This continuous framework allows the generation of high-quality and diverse sequences for complex biological tasks. 3. To enhance controllability, the authors propose Straight-Through Guided Flow (STGFlow), a training-free guidance technique that uses pre-trained classifiers to steer the generative model towards desired sequences. This enables efficient optimization of peptide binders, DNA promoters, and protein sequences. 4. Gumbel-Softmax Flow Matching is applied to various biological sequence generation tasks: conditional DNA promoter design, de novo protein sequence generation, and target-specific peptide binder design. The framework demonstrates competitive performance compared to state-of-the-art models in each task. 5. For peptide binder design, Gumbel-Softmax Flow Matching generates novel peptides with high binding affinity to proteins associated with rare diseases, such as Huntington’s Disease-Like 2 and Alexander Disease. It achieves superior performance in both docking scores and structure predictions compared to existing peptides. 6. The proposed framework provides a scalable and theoretically grounded approach for sequence generation, with potential applications in RNA sequence engineering, regulatory circuit design, and other structured biological design tasks. 💻Code: huggingface.co/ChatterjeeLab… 📜Paper: arxiv.org/abs/2503.17361 #GumbelSoftmaxFlow #STGFlow #BiologicalSequenceGeneration #PeptideDesign #ProteinDesign #DNAEngineering #MachineLearning #Bioinformatics #DeepLearning

Precise DNA Breaks by CRISPR-SpRYgests Improves #DNAEngineering A new study demonstrates that a SpCas9 variant, SpRY, is PAMless in vitro and can cleave DNA at practically any sequence. Learn more: ow.ly/g20J50L3yCn #CRISPR

Precise DNA Breaks by CRISPR-SpRYgests Improves #DNAEngineering A new study demonstrates that a SpCas9 variant, SpRY, is PAMless in vitro and can cleave DNA at practically any sequence. Learn more: ow.ly/g20J50L3yCn #CRISPR

Oh my, I kinda knew this. But this just makes me sick. #DNAengineering #BirthDefects #mRNA #COVIDVACCINE

"And we will be able to send it to the TangoLab facilities on the ISS!" #materialscience #DNAengineering filling-space.com/2019/03/19…

#technology #future #futuretechnologies #imarketology #wix #biotechnology #biotech #biotechnologies #stemcell #DNAengineering #DNAediting #syntheticbiology #energy #cleanrenewableenergy #solarcells A Glimpse About 7 Technologies of The Future #wattpad my.w.tt/b5pOcinhO5

"Via an organization called Technicians without Borders, I met Joram, an Aerospace Engineering Student." #DNAengineering #aerospaceengineering filling-space.com/2019/03/19…

Some call it "THE NOTHING" while others refer to it as, "THE SOMETHING." POW! 🚀 travisborne.com Proofed by @WordRefiner #computerfiction #timewarp #whitehole #scifihorror #DNAEngineering #DNA #ai #ArtificialIntelligence #technothriller #LENDERS #suspense #YAFantasy

In his research Jiankui altered embryos of seven couples during their fertility treatments.... newstrack.com/lifestyle-news… #China has successfully delivered its first #geneticallymodified twins! #Science #Health #Microbiology #DNAengineering #CRISPR #CRISPERCAS9 #Medicalscience

bespoke design, ask us and we make your dream come true, mercedes G class with a Rolls-Royce front look #bespoke #custom #stylish #luxurylifestyle #luxurycars #dnaengineering #mclarenbits instagram.com/p/Bow81r_h_5c/…

Double helix pedestrian solution #DNAengineering

Get use to #blockchain #Fintech #Bitcoin #IoT #dnaengineering #cryptocurrency #AI #AugmentedReality #neuroscience #disruptivetechnology

Yur own DNA Editing Will Remake the sickly you. CRISPR wired.com/2015/07/crispr-dna… #crispr #dnaengineering #genetics #dnareprogram #vr #ar #ai

@FionaLakeAus What's it with the male of our species that they can't throw out TP roll?!? Is there some sort of blip in their DNAengineering