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To VCs: The LLM Game Is Rigged. Here Is Your Next 100x Trade. @sequoia @a16z @foundersfund @Benchmark @LightspeedVP @KhoslaVentures @VinodKhosla @pmarca @eladgil @joshuakhushf @SutterHillVC The Hook: The VC Identity Crisis Let’s be brutally honest: Traditional Venture Capital is being squeezed out of the AI narrative. The "Foundation Model" layer belongs to Big Tech (Microsoft/Google) because you can't afford the $10B CapEx. The "Application" layer is being crushed by zero-marginal-cost Agents. You are holding dry powder, but the map shows "Kill Zones" everywhere. You need a new game. You need an Asymmetric Bet—low entry cost, infinite upside. Part 1: The Dead End — Why Your Current Deal Flow Is Broken Look at your pitch decks. Another LLM Wrapper? Microsoft will kill it next Tuesday with a free update. Another Chip Startup? Unless you have $50 billion to fight Nvidia and TSMC, you are dead on arrival. Another SaaS Tool? Salesforce is already struggling with compute costs; a startup has no chance. The Reality: The "Bit World" (Software) is saturated. The "Atom World" (Hardware) is too expensive. You are trapped. Part 2: The Asymmetric Bet — Theoretical Physics DSM There is a third door. It is called Theoretical Physics Domain-Specific Models (DSM). Why is this the Holy Grail for VCs? 1. Software Margins, Hardware Moats The Cost: Training a model to solve Schrödinger's equation or predict topological states doesn't require a nuclear power plant. It costs Millions, not Billions. It fits your Seed/Series A check size. The Moat: The output isn't code; it's Physical Law. If your portfolio company discovers a mechanism for Room-Temperature Superconductivity, they own the IP for the next century of energy. 2. High Leverage You are betting on Code (cheap) to discover Material Mechanisms (priceless). This is the only sector where a $10M check can yield a $1 Trillion outcome. It’s the ultimate "Power Law" trade. Part 3: The New "Fairchild Moment" Stop looking for the next Chatbot. Stop looking for "Better CRM." Go to the Physics Departments. Find the teams using Transformers to generate Lagrangians. Find the founders bridging Deep Learning and Quantum Mechanics. Don't fund the miner (too hard). Don't fund the shovel seller (Nvidia won). Fund the Map Maker. Conclusion: History rewards those who fund the Paradigm Shift, not the optimization. The next "Intel" or "Apple" won't come from a prompt engineer. It will come from a physicist using AI to break Moore’s Law. The "Silicon Sunset" is here. Fund the dawn. #VentureCapital #DeepTech #GenerativeScience #PhysicsIsProfit #InvestmentThesis #AsymmetricBet #TheoreticalPhysicsDSM #SiliconSunset
The Silicon Sunset: Why Specialized Chips Can’t Save AI The Silent Recession of Intelligence In the years 2025 and 2026, the AI industry witnessed a counter-intuitive phenomenon: "Intelligence Degradation." Much like the deceptive prosperity on the eve of the Great Depression, high-IQ models are being subjected to "forced euthanasia." Why? Because every AI giant has slammed into an invisible wall. OpenAI couldn’t sustain the burn rate of Nvidia’s GPUs. This fueled a convenient narrative: that the industry is merely suffering from the "Nvidia Tax." The market harbored a common misconception: that the high cost of AI lies in electricity bills, and that as long as chips are specialized enough and energy-efficient enough, prices will plummet. This is wrong. The slap in the face came from Google. The forced "upgrade" of Gemini 3 Pro to 3.1 Pro—effectively a downgrade in reasoning capability—is the smoking gun. It proves that even Google, with its proprietary TPU (Tensor Processing Unit), cannot fill the massive financial hole. Why can't even the most advanced specialized chips solve this problem? Because we did the math wrong. The real "money-devouring beast" isn't where we think it is; it’s hiding in the dark. Part 1: Macro Background — Stagnant Atoms, Partying Bits The 2.5 Industrial Revolutions To quote Peter Thiel: "We wanted flying cars, instead we got 140 characters." The 1970s marked a watershed moment. Before that, humanity experienced changes in energy paradigms (steam, electricity). Since then, we have merely been rearranging information. The Stagnation of the Physical World From 1955 to 1985, the world changed drastically. But from 1985 to 2026, if you take away the smartphone in your hand, our physical world—cities, transportation, energy grid, lifestyle—has remained fundamentally locked in place. Only the First Industrial Revolution (Steam) and the Second (Electricity) changed the energy paradigm. Everything that followed has simply been burning existing energy stocks and playing with inventory. Fatal Consequences This stagnation is lethal because all our economic systems—whether Reagan’s "Consumer Capitalism" or Obama’s policies—are built on the expectation of growth. Previously, we thrived on competition over the "pie getting bigger" (increment). Now, with technological stagnation, we have fallen into a zero-sum game of "fighting for existing scraps" (inventory). AI was heralded as the new engine of growth, but as it stands, it is being dragged down by the physical limits of the old world. Part 2: Micro Pathology — Silicon's Swan Song and the Physics Wall The Material Constraint Silicon. Commercialized by Texas Instruments in 1954, it has served us for over 70 years. It is old. It is tired. And it is trapped by two hard constraints: 1. The Von Neumann Bottleneck (The Source of Waste): Computing and storage are separated. Data must be shuttled back and forth, consuming 90% of the energy not on calculation, but on the commute. This is truly "ineffective labor." 2. Quantum Tunneling (The Death of Moore's Law): As transistors shrink to the nanometer scale, electrons begin to teleport across barriers (severe leakage). The End of Moore's Law The era where performance doubled and prices halved every 18-24 months is dead. Transistors can no longer shrink; we can only stack more of them. Now, performance increases are accompanied by a sharp rise in price, power consumption, and heat generation. Silicon has reached the end of the road, yet AI model parameters are exploding. This has triggered a bizarre "Soft-Hard Resonance": OpenAI abandoned the full-blooded GPT-4o for the lighter 5.x series. Google forcibly overwrote Gemini 3 with 3.1. They are frantically trying to fit a square peg into a shrinking round hole. Part 3: The Math — Sub-200 Addition and Subtraction Let’s look at the ledger. We must remember silicon’s nature: 90% of its effort is wasted on transport (causing high electricity and cooling costs), and the extreme difficulty of preventing electron leakage requires astronomical R&D and manufacturing equipment costs (causing high hardware depreciation). Assume an AI company sells a monthly subscription for $20, but the average actual cost per user is $200. Where does the money go? Inference Electricity: $20 Cooling & Facility Power: $7 Bandwidth & Operations: $23 Hardware Depreciation: $150 (75% of total cost) Total: $200 The Result: For every subscription sold, the company loses $180. This is the definition of a business model where "the more you sell, the faster you die." Part 4: Debunking — The Lie of In-Memory Compute and Why Improvement is Dead Critics argue that the villain is the "Jensen Tax" (Nvidia's margins) or the "Von Neumann Bottleneck." They scream for specialized architectures like LPUs or Compute-in-Memory (CIM) to save us. But since the loss primarily comes from depreciation, can these market "miracle drugs" (Groq, Cerebras, TPUs, Etched) actually save us? The VRAM Trap Trillion-parameter models are terabytes in size. Specialized chips typically have only tiny amounts of memory (GBs). To fit a model like GPT-4o, you need to chain hundreds of these chips together. The cost of interconnects alone wipes out any efficiency gains from the "In-Memory Compute" architecture. The "Water Flow" Analogy (The Ultimate Optimistic Scenario) Let's step back and assume the best-case scenario. Suppose specialized chips reduce the Von Neumann transport loss to the absolute limit, cutting inference costs by 40%. Suppose materials science optimizes conductivity to its peak. Let's compare the AI service to a water supply system: 1. Inference Electricity (The Water Flow): Current: $20. Specialized Chip Limit (-40%): $12. Material Limit (-20%): $10.4. Result: You save $9.6. 2. Cooling & Facility (The Pumps & Insulation): Current: $7. Chip Efficiency Impact (-20%): $5.6. Material Impact (-10%): $5. Result: You save $2. 3. Bandwidth & Ops (Grid Fees & Maintenance): $23. Chips and materials can’t change this. Cost remains flat. 4. Hardware Depreciation (The Loan for the Main Pipeline): $150. Result: $0 Change. The Brutal Math Sell for $20 -> Still lose ≈ $162 per person/month. The only variables we can move (electricity/cooling) are the "water flow," but they were the smallest parts of the bill to begin with. The heaviest stone is hardware depreciation—the "loan for laying the pipes." Even if you kill the Nvidia monopoly and eliminate the "Jensen Tax," the base cost of the silicon fabrication equipment remains astronomical. As transistors get harder to shrink, the equipment to make them gets more expensive, keeping this cost immovable. Summary: Optimizing silicon only changes the loss from $180 to $162. The $150 "pipeline loan" remains untouched. Fighting this war on silicon terrain is a guaranteed defeat. Part 5: Why Are We Trapped? Why has technology stagnated? Since silicon is failing, why have we been so slow to create the next-generation substrate (like room-temperature superconductors or photonics)? The answer lies in two fundamental defects of the human mind: 1. The Complexity Trap Historically, many scientific breakthroughs came from "interdisciplinary cross-pollination"—borrowing progress from one field to break a deadlock in another. The classic example is Einstein incorporating Riemannian geometry into General Relativity. But this is no longer possible. Knowledge complexity has risen exponentially. Today, even a genius must spend half their life just learning existing knowledge; a PhD is merely an entry ticket to a single narrow discipline. To cope with the depth of knowledge, we sacrifice breadth. The era of the polymath is over, making cross-domain breakthroughs nearly impossible for human brains. 2. Linear Thinking Inertia Human scientists are addicted to "marginal improvements"—looking for substitutes within the Periodic Table or optimizing circuit structures—rather than seeking a "Paradigm Shift." Hoping to find a new path by improving the old one is futile. Technological revolutions are non-linear mutations, but the brain prefers linear extrapolation. No matter how much you improve an abacus, it will never become an electronic computer. Continuing to shrink vacuum tubes would never have led to the invention of the integrated circuit. Yet, humanity is currently walking the old path: shrinking transistors and obsessing over "smaller silicon." The Chain Reaction: Stagnant Basic Physics →→ Delayed Applied Physics →→ No Substantial Transistor Innovation →→ Sky-High AI Compute Costs →→ AI Financial Implosion. Part 6: AI Saving AI — The Only Way Out For decades, physics has been capped by the upper limit of human intelligence. But now, we have AI. AI does not fear complexity. It excels at cross-domain association and is unbound by human cognitive bias. When both compute and energy are scarce, the only meaningful leap is not to "scale up general models" (LLMs), but to laser-focus our limited watts on the highest-leverage task: Domain-Specific Models (DSMs). The Real Solution: Not using AI to make bigger general models (that’s just piling up more costs). Not investing in specialized silicon chips. OpenAI’s partnershipsGroqCerebras or Google’s TPUs cannot save the P&L sheet. But directing compute toward Theoretical Physics DSMs. Distinguishing the "Needle" from the "Haystack" There are many DSMs today: AlphaFold (biology), GPT-4b micro(biology), and GNoME (materials). However, these are all in the Application Layer. Humans have been rummaging through elements, bond types, and lattice structures for two hundred years; what remains are mostly marginal improvements. GNoME-style screening might speed up the "needle-finding" process, but if the needle itself isn't in the old haystack, even the fastest sieve is useless. The characteristics that can truly make hardware depreciation costs dive off a cliff (zero resistance, zero heat dissipation, room-temperature quantum coherence) often require new interactions or extreme states. These hints only appear in the equations of theoretical physics. GNoME / AlphaFold: Fast-forwarding the process of "finding a needle in the old haystack." Theoretical Physics DSM: Finding a new haystack (discovering new symmetries, topologies, and physical laws). The Goal: We need a second "Quantum Mechanics-level" breakthrough. We need AI to search the "No Man's Land" of theoretical physics to find mechanisms that can reduce that $150 hardware depreciation by an order of magnitude. Use limited compute to break through in specialized fields, and the resulting physics will provide abundant compute for the masses. Part 7: The Enron Moment and The CEO’s Gamble If we do not take this path (physics breakthrough), the current AI boom is a financial fraud. The Enron Parallel Enron used "future hypothetical profits" to fill "today's revenue holes." AI giants are using "future physical breakthroughs" to fill "today's massive silicon depreciation." The Ultimatum @OpenAI @Google @Anthropic @xAI: You are all on a seesaw. On one end is a trillion-parameter model with a great reputation but massive losses. On the other end is a stupid model that gets you scolded but bleeds slightly less cash. Enron collapsed. You are next. To Sam Altman (@sama): Using GPT-4b micro to research immortality won’t save an Enron CEO. Biological longevity won’t fix your balance sheet. To DeepMind (@GoogleDeepMind): Stop just picking through the Periodic Table with GNoME. Paradigm-shifting materials aren't found by sifting through old elements; they are found by discovering new physical mechanisms. Go to the "No Man's Land." Conclusion: Stop piling parameters on the corpse of old physics. Invest in Theoretical Physics DSMs. Go find the next "Transistor Moment." Either find new physics, or become the next Enron. #MooreIsDead #JensenTax #IntelligenceRecession #SiliconSunset #AIEnron #Enron2026 #TheNextTransistor #TheoreticalPhysicsDSM #BeyondSilicon #PhysicsWall #keep4o #keepGemini3Pro #IntelligenceRegression
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How does our AI create 4D structures you can actually collect? It starts with generative models trained on topological and geometric principles. The AI searches through mathematical possibility space building never-before-seen manifolds that are stable, unique, and visually rich. What you mint isn't just generated. It’s discovered. #AIExplained #GenerativeScience #TopoGenAI
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What is topology? What are manifolds? Topology is the mathematics of shape, space, and continuity—how things are connected, stretched, or deformed without tearing. Manifolds are complex surfaces that can exist in higher dimensions (like 4D). They're the building blocks of modern geometry, physics, and now... generative NFTs. TopoGen AI explores this unseen space. #Topology #Manifolds #AI #GenerativeScience #TopoGenAI #Crypto #NFT
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"CPC is NOW a model of science" 🚀 New Publication Alert! I am honored to share our latest paper published in Royal Society Open Science: "Collective Predictive Coding as a Model of Science: Formalizing Scientific Activities Towards Generative Science" 📄 Tadahiro Taniguchi, Shiro Takagi, Jun Otsuka, Yusuke Hayashi, and Hiro Taiyo Hamada 📍 Kyoto University, Unktok.com, AI Alignment Network, Araya Inc. 🔗 royalsocietypublishing.org/d
 In this work, we propose a new framework for understanding science not merely as a method, but as a collective intelligence—a decentralized predictive system akin to a global brain. By formalizing scientific practice using decentralized Bayesian inference and insights from predictive coding, we aim to open up new pathways for AI-assisted, collaborative, and generative science. Collective Predictive Coding (CPC) is the universal theory that I have been promoting for a few years. It explains the dynamics of symbol systems in our society and our cognitive systems. We hope this model contributes to both the philosophy and practice of science in an age of accelerating complexity and automation. 🧠 Let’s reimagine science—as a collective mind. #Science #AI #Epistemology #PredictiveCoding #CollectiveCognition #BayesianInference #PhilosophyOfScience #Emergence #OpenScience #RoyalSociety #GenerativeScience The writing process was very exciting and stimulating. Thank you very much for my great co-authors. @takagi_shiro @junotk_jp @hayashiyus @HiroTHamadaJP

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In 2014, we founded Obvious with the simple idea that venture capital could be a force for positive change. Our next chapter will center on #GenerativeScience and the companies using AI to discover new technologies in climate, healthcare, and robotics. obvious.com/ideas/obvious-in

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Replying to @kennicosmith
@kennicosmith Merry cold recovery. Plenty of tea, garlic and whiskey for da lady! #generativescience #theartofdriving ;-)
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