2 Oct 2025
They all fuse and melt cells like “chewing gum”.. given the right conditions. Here is XFG with ACE2 SLCA619 TMPRSS2. I guess the question here is IF it does this in lots of different conditions like pre-Omicrons. Conditions you would observe in the lung for instance.
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2 Oct 2025
Yeah I know but that pairing are never great and its got my syncytia spidey sense tingling - @guptalab @BagaiDr @SystemsVirology @StuartTurville @GuptaR_lab is it any more fusogenic.
I didn't reactive for laughs...
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22 Sep 2025
ORF1a:L3338F has been one of the more common NSP5 muts. Don't think it's a resistance mut. I'd guess it's a relatively inconsequential site. NSP5 still a great target. We need drugs targeting other proteins as well. Promising M-directed drugs in pipeline.
13 Sep 2025
...to the recent discovery of two promising M-directed small molecules that prevent the short-to-long transition of M, which is essential for viral assembly. Both studies were released in the March 26 edition of Nature. nature.com/articles/s41586-0…
nature.com/articles/s41586-0…
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22 Sep 2025
I’m also not convinced that Paxlovid is deployed enough and used early enough to put much evolutionary pressure on viral transmission.
But I’m happy that so far SARS-CoV-2 has not evolved Paxlovid resistance on a large scale.
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22 Sep 2025
XFG.3.13 Orf1a:L3338F. I'm old enough to remember when NSP5 was highly conserved and a great target for antivirals. First Paxlovid mute ? @LongDesertTrain @guptalab
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17 May 2025
Presenting PhD candidate @MichelleLRay14 in the #GuptaLab @CCLRI @ClevelandClinic @CWRUSOM Congratulations, Michelle!! You rock 👏🏽💪🏽 🎉😊🥂
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Check out the latest #StructureCellPress paper, "Structural insights into the assembly and regulation of 2′-O #RNA methylation by #SARS-#CoV-2 nsp16/nsp10," co-authored by members of the #GuptaLab!
tinyurl.com/mrxvps2w
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25 Mar 2025
While attack on conserved epitopes provides a ready mechanism for a broad spectrum antibody, it may NOT be easy to find such mechanism for a mutant capable of evading polyclonal antibodies. Immune suppression is NOT likely to occur before infection.
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24 Mar 2025
I originally thought the 69/70 del helped the virus evade polyclonal Abs. In reality, it mainly impairs monoclonals like Ab 4A8 that target the NTD, which IMO likely explains why studies using polyclonal sera might not detect its specific immune-evasive impact.
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24 Mar 2025
Logically, Cov wouldn’t be forced to ditch any binding epitopes unless it was an impediment to avoiding Ag receptors.
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24 Mar 2025
I did. Much like most selection pressure its necessity depends on mass, recent population exposure.
5 Aug 2024
But the 69/70 deletion is still necessary to minimise sensitivity to polyclonals convalescent or vaccinated. It’s another optimal tradeoff mute like others selected downstream. Significantly ups binding whilst minimising its Ag signature.
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25 Jan 2025
Always time for cake! Happy Birthday to Srishti Deb, freshman @CWRUSOM participating in #immunotherapy research in the #GuptaLab @CCLRI @ClevelandClinic 🎂🥳 #WomenInSTEM
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19 Sep 2024
Yesterday we celebrated the achievements of our postdocs @hemanta_datta, Jonathan and Rachel, and thanked them for advancing #GuptaLab research @CCLRI @ClevelandClinic @CleClinicKids during #NPAW2024 🎊🥳 We also bade farewell to @RileyK126 and wish her the best in PA school 👍🏽💪🏽
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15 Aug 2024
Celebrating 17 years of the #GuptaLab @CCLRI @ClevelandClinic @CleClinic_PHO 🥳 Thankful for trainees, mentors, resources @NIH 🙏🏽 Will continue to better understand #BCells and #CARTCells to help patients with #infection, #autoimmunity and #cancer 💪🏽
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14 Aug 2024
Bidding farewell to our phenomenal @CCLRI summer students Afreen @KentState and Allison @BostonCollege, I couldn’t think of a better gift than @kkariko’s beautiful autobiography. I hope you will enjoy and be inspired by it. So proud of you! #GuptaLab #WomenInSTEM #BCells
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23 Jun 2024
Two lab graduations, in true Hollywood #Oscars style - @jaimebaldeonm finishing @CleClinic_PHO fellowship, going to @CincyChildrens & Alex Kuo completing postbac research, going to @UMmedschool!! #ProudPI #BCells #GuptaLab @CCLRI @CleClinicKids @ClevelandClinic
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4 Apr 2024
3 Apr 2024
Congratulations to @jaimebaldeonm, our very own @CleClinic_PHO third year fellow, as this year's recipient of #ASPHO2024 Early Career Travel Stipend Award, thanks to @neetuguptaphd for your mentorship ! @ASPHO_hq
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3 Nov 2023
VivianaJimenez and XiaoboLi rocking their poster presentation at #ASN
Novel therapeutics for #LupusNephritis targeting innate immune cells. Lowering #suPAR and reducing #Kidneydamage. 👏👏👏
First of three posters from #Guptalab this week.
@RushDOIM
@JochenReiser
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