RSV & hMPV remain unmet needs. In @CellRepMed, we report #LIBRAseq-discovered cross-reactive #antibodies that neutralize both #viruses. mAb 5-1 shows strong potency, in vivo protection, broader reactivity than current leads, and features supporting translational development.
1
1
6
208
3 Mar 2025
🧬My new paper is up on bioRxiv!
Contrastive Learning Enables Epitope Overlap Predictions for Targeted Antibody Discovery
📄 doi.org/10.1101/2025.02.25.6…
@IG_lab
#Immunology #MachineLearning #LIBRAseq 🧵1/5
2
1
7
407
4 Dec 2024
This manuscript is now published in Bioinformatics Advances: Optimizing #LIBRAseq #antibody-#antigen specificity assignments
Negative Binomial Mixture Model for Identification of Noise in Antibody-Antigen Specificity Predictions from Single-Cell Data academic.oup.com/bioinformat…
4
14
1,100
8 Sep 2023
A large-scale #LIBRAseq atlas of #antibody-#antigen pairs sheds light on important questions underlying the relationship between antibody sequence and antigen specificity, and provides insights into population-level responses.
biorxiv.org/content/10.1101/…
1
18
57
8,605
16 Jun 2022
My favorite parts of our paper: the CyTOF data is stunning. I had never heard of LIBRASeq before and it’s incredible. My take on the metabolism, though: the T cells that responded to spike were lower than you’d expect for Glut1, but high for CD71 (Tfrc).. prob require high iron!
16 Jun 2022
A big effort @VUMC_VCI @VUMC_Vaccines with 3x1st authors Kevin Kramer @DoctorKvoss Erin Wilfong and 4 senior @jonathanirish @IG_lab @BonamiRachel to find the B and T cells that drive COVID vaccine response, poor responders & a breakthrough
nature.com/articles/s41467-0…
2
20
23 Mar 2022
High-throughput discovery of #epitope-specific #antibodies? There's a #LIBRAseq for that. Great collaborative effort led by @LaurenW_Science.
High-Throughput B Cell Epitope Determination by Next-Generation Sequencing frontiersin.org/article/10.3…
1
8
27
3 Mar 2022
#LIBRAseq with ligand blocking enables targeted discovery of functional (not just binding) #antibodies.
Double #ACE2-blockers for both #SARSCoV2 and #SARSCoV were also identified.
Easily generalizable for #mAb discovery aiming to block other types of antigen-ligand interactions
3 Mar 2022
Efficient discovery of SARS-CoV-2-neutralizing antibodies via B cell receptor sequencing and ligand blocking go.nature.com/35O9Ali
3
14
48
10 Dec 2021
Join us & learn about NEW products & technologies that can advance your SARS-CoV-2/Omicron research.
FEATURING:
•SARS-CoV-2 reagents from @SinoInc
•@PacBio HiFi Viral
•OpenSPR from @Nicoya_Life
•@10xGenomics LibraSeq
REGISTER HERE: bit.ly/3Gi3Ehq
3
5
22 Nov 2021
Thoroughly characterise B cells by applying TotalSeq™ antibodies in conjunction with LIBRA-seq to simltaneously profile B cell antigen specificities and BCR sequences at the single-cell level.
#citeseq #multiomics #singlecell #totalseq #scrnaseq #sequencing #libraseq #bcrseq
19 Nov 2021
Discover how our recombinant proteins and TotalSeq™ reagents can be used in innovative multiomics applications, like LIBRA-seq, for antigen-specific B cell characterization. bit.ly/3kjD0w2
2
8
29 Jul 2021
T-REX @jonathanirish found the antigen specific CD4 and CD8 T cells and LIBRAseq @IG_lab found the B cells. Great scRNAseq @BonamiRachel and T cell profiles ( metabolism!) @DoctorKvoss in my group. Lot's of interesting new biology with important implications! @VUMCResearch
1
9
29 Jul 2021
Great collaborative work with lots of cool findings, including #LIBRAseq characterization of the evolution of B cell antigen specificity at the single-cell level from before to after #SARSCoV2 vaccination.
28 Jul 2021
Single-Cell Profiling of the Antigen-Specific Response to BNT162b2 SARS-CoV-2 RNA Vaccine biorxiv.org/content/10.1101/…
6
27
28 May 2021
New paper from @IG_lab, @AShiakolas, @kjkramer6, et al. identifying cross-reactive antibodies with #Libraseq. @VanderbiltCSB #SARSCoV2
Thank you for using #TwistGenes!
Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc...bit.ly/2Tdpf7d
1
6
Science from the @IG_lab‼️ Take a look at this #LIBRAseq work from co-first authors @AShiakolas & @kjkramer6 describing cross-reactive coronavirus antibodies diverse epitope specificities and Fc effector functions 👏👏 sciencedirect.com/science/ar…
4
10
12 May 2020
Please RT: My new lab at ETH D-BSSE in Basel, Switzerland is looking for a wet-lab postdoc to study antigen-BCR interactions with LibraSeq. Ideally, you have a background in immunology or single cell genomics and a strong interest in antibody research. Please get in touch via DM.
2
110
72
30 Apr 2020
2/ It's Thursday, which means the Georgiev Lab is having its weekly lab meeting! Today happens to be my turn to present to fellow labmates my research progress over the past few months. #antibodydiscovery #libraseq
1
6
6 Feb 2020
1
2
11
19 Jan 2020
Thanks for the blog post, @OPIGlets : blopig.com/blog/2020/01/para… . We, too, hope #libraseq will speed up mAb discovery!
1
2
7
16 Dec 2019
Added #LIBRAseq LIBRA-seq to the list of #singlecell #omics #protocols table bit.ly/comii cell.com/cell/fulltext/S0092…
4