This new article from Paul Iyyanar, Nirpesh Adhikari, Yu Lan & Rulang Jiang shows that ALX1 is a crucial transcription factor acting upstream of the gene regulatory network that controls cranial mesoderm patterning and craniofacial #muscledevelopmentdoi.org/10.1242/dmm.052241
ALT Microscopy images showing that transient mesodermal Alx1 expression is essential for extraocular muscle (EOM) myogenesis. Top panels illustrate the transient window of ALX1 expression (magenta) in GFP cranial mesoderm at E8.5 (left), followed by its shift to neural crest lineage cells by E9.5 (right). Bottom panels demonstrate that mesoderm-specific Alx1 inactivation leads to the total loss of all seven EOMs (right) by E16.5, compared to the organized EOMs in controls (left; muscle actin is shown in magenta).
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Resipher in action! Check out this example of the platform's impact on stem cell metabolism and differentiation research.
This study examined how loss of HMGCR, the rate-limiting enzyme in cholesterol synthesis, affects muscle development. Using Resipher, the authors measured oxygen consumption in myotubes derived from HMGCR-deficient myoblasts, revealing impaired mitochondrial respiration and reduced spare respiratory capacity. Resipher was instrumental in showing how lipid biosynthesis and mitochondrial metabolism are tightly linked during muscle differentiation.
Read the full paper here >>> febs.onlinelibrary.wiley.com…#MuscleDevelopment#HMGCR#Bioenergetics#Mitochondria#Resipher
Boost your metabolic health by lifting weights! Muscles are glucose powerhouses and have a high metabolic rate, making them key for effective weight management. Prioritize muscle development to reach your health and fitness goals. #MuscleDevelopment#WeightManagement