Multi-level #SingleCellAnalysis reveals reduced TCR diversity, #CD4 depletion, and expansion of cytotoxic yet exhausted CD8 effector cells in #ChronicMyeloidLeukemia, driven by altered #BoneMarrow microenvironment interactions. @hzau_1898 #OpenAccess: doi.org/10.1016/j.gendis.202…

📣Call for Reading: #Review Recent Developments (After 2020) in Flow Cytometry Worldwide and Within China by Xinyue Du et al. mdpi.com/2079-6374/15/3/156 #FlowCytometry #SingleCellAnalysis #biosensors #mdpi #openaccess

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease! Postdoctoral Fellow in Chromatin Biology and Genomics National Cancer Institute, National Institutes of Health See the full job description on jobRxiv: jobrxiv.org/job/national-can… #chromatinbiology #chromatinorganization #epigenomics #generegulation #singlecellanalysis #topoisomerasednasupercoiling #ScienceJobs jobrxiv.org/job/national-can…

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease! Postdoctoral Fellow in Chromatin Biology and Genomics National Cancer Institute, National Institutes of Health See the full job description on jobRxiv: jobrxiv.org/job/national-can… #chromatinbiology #chromatinorganization #epigenomics #generegulation #singlecellanalysis #topoisomerasednasupercoiling #ScienceJobs jobrxiv.org/job/national-can…

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease! Postdoctoral Fellow in Chromatin Biology and Genomics National Cancer Institute, National Institutes of Health See the full job description on jobRxiv: jobrxiv.org/job/national-can… #chromatinbiology #chromatinorganization #epigenomics #generegulation #singlecellanalysis #topoisomerasednasupercoiling #ScienceJobs jobrxiv.org/job/national-can…

𝗙𝗿𝗼𝗺 𝘀𝗻𝗮𝗽𝘀𝗵𝗼𝘁𝘀 𝘁𝗼 𝗺𝗮𝗽𝘀: 𝗦𝗽𝗮𝘁𝗶𝗮𝗹𝗢𝗠𝗜𝗫 𝗦𝘆𝗱𝗻𝗲𝘆 𝗱𝗲𝗹𝗶𝘃𝗲𝗿𝘀 💥 Over two days, this symposium brought together national and international leaders in spatial biology to explore how spatial transcriptomics, proteomics, high-resolution imaging and advanced analytics are transforming the way we study health and disease. From keynote addresses by Jared Burks (University of Texas MD Anderson Cancer Centre) and Joe Yeong (Singapore’s Agency for Science, Technology and Research) to sessions from leading researchers and industry partners spanning diagnostics, data analysis and multi-omics in complex tissues, the program showcased the depth and momentum of this rapidly advancing field. It also marked the official launch of the 𝗦𝗽𝗮𝘁𝗶𝗮𝗹 𝗣𝗮𝗻-𝗢𝗺𝗶𝗰𝘀 𝗜𝗻𝗶𝘁𝗶𝗮𝘁𝗶𝘃𝗲 (read more here 👉 bit.ly/4tpVyg5). A huge thank you to our speakers, sponsors and delegates for contributing to such a dynamic exchange of ideas. Staged by Sydney Cytometry and Sydney Mass Spectrometry, #USYD Core Research Facilities, this symposium reflects our strengths in enabling cutting-edge, collaborative research that connects molecules, cells and tissues in true biological context. With thanks to our sponsors: Bruker, Aim Discovery Solutions, Standard BioTools, Chameleon Science, Miltenyi Biotec, MetaGene Pty Ltd, 10x Genomics, Millennium Science, Lunaphore (a Bio-Techne brand) and BioGenex. About 𝗦𝘆𝗱𝗻𝗲𝘆 𝗖𝘆𝘁𝗼𝗺𝗲𝘁𝗿𝘆 ➡️ bit.ly/3nhaNL7 About 𝗦𝘆𝗱𝗻𝗲𝘆 𝗠𝗮𝘀𝘀 𝗦𝗽𝗲𝗰𝘁𝗿𝗼𝗺𝗲𝘁𝗿𝘆 ➡️ bit.ly/3pzvEdC @MDAndersonNews @astar_research @bruker @Standard_BioT @ChameleonSci @miltenyibiotec @10xGenomics @mscienceaustnz @lunaphore @biogenex #SpatialOmics #PanOmics #SpatialBiology #Biotechnology #LifeSciences #Genomics #CellBiology #BiomedicalResearch #SingleCellAnalysis #TissueMapping #PrecisionMedicine

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease! Postdoctoral Fellow in Chromatin Biology and Genomics National Cancer Institute, National Institutes of Health See the full job description on jobRxiv: jobrxiv.org/job/national-can… #chromatinbiology #chromatinorganization #epigenomics #generegulation #singlecellanalysis #topoisomerasednasupercoiling #ScienceJobs jobrxiv.org/job/national-can…

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease! Postdoctoral Fellow in Chromatin Biology and Genomics National Cancer Institute, National Institutes of Health See the full job description on jobRxiv: jobrxiv.org/job/national-can… #chromatinbiology #chromatinorganization #epigenomics #generegulation #singlecellanalysis #topoisomerasednasupercoiling #ScienceJobs jobrxiv.org/job/national-can…

Interpretation, Extrapolation and Perturbation of Single Cells @NatureRevGenet 1. This review article explores the transition of single-cell analyses from descriptive atlasing to inferring causal effects and mechanistic relationships. It highlights how technological advances have spurred the development of machine learning methods to identify dependencies and extrapolate perturbation effects. 2. The authors propose a unifying ontology to guide practitioners in selecting suitable methods for specific biological questions. This ontology connects approaches based on their modeling concepts, underlying assumptions, and downstream tasks, providing a structured way to navigate the complex landscape of single-cell perturbation analysis. 3. A key focus is on understanding perturbation responses at multiple levels, from differential expression to gene associations and directed networks. The article emphasizes the importance of disentangling cellular variation into distinct components to capture specific perturbations and biological pathways. 4. The review also discusses the challenges of modeling and evaluation, noting the mismatch between model complexity and the completeness of available data. It highlights the need for standardized model evaluation and benchmarking to objectively assess methodological advances. 5. Looking ahead, the authors identify promising computational directions and underexplored data properties that could pave the way for future advancements. They stress the importance of integrating diverse data types and causal signatures to resolve when, where, and how perturbations propagate through molecular layers. 📜Paper: nature.com/articles/s41576-0… #SingleCellAnalysis #CausalModeling #PerturbationBiology #MachineLearning #ComputationalBiology

Scaling Large Language Models for Next-Generation Single-Cell Analysis 1. A novel study introduces C2S-Scale, a novel framework leveraging large language models (LLMs) to transform single-cell RNA sequencing data into "cell sentences," enabling scalable and unified analysis of cellular diversity. 2. This innovative approach scales models up to 27 billion parameters, significantly enhancing predictive and generative capabilities across diverse single-cell tasks, including perturbation response prediction and complex biological reasoning. 3. C2S-Scale integrates multimodal data, combining transcriptomic profiles with rich textual metadata and biological context, surpassing both specialized single-cell models and general-purpose LLMs in performance. 4. The study demonstrates C2S-Scale's ability to identify novel therapeutic candidates through virtual screening, successfully predicting context-dependent effects on antigen presentation and validating them experimentally. 5. This work highlights the potential of LLMs in bridging the gap between transcriptomic data and natural language interpretation, offering a powerful platform for next-generation single-cell analysis and personalized medicine. 📜Paper: biorxiv.org/content/10.1101/… #SingleCellAnalysis #LargeLanguageModels #Bioinformatics #Genomics #NextGenSequencing

Postdoc in macrophage heterogeneity and Mtb infection using murine/NHP models, CRISPR, multiomics, flow cytometry, and BSL3 research. Post-Doctoral Fellow, Pisu Lab Tulane University See the full job description on jobRxiv: jobrxiv.org/job/tulane-unive… #CRISPRscreen #macrophage #singlecellanalysis #tuberculosis #ScienceJobs jobrxiv.org/job/tulane-unive…

Our 1st 2 #nanocourses of #Spring2026 are open for registration! #MATLAB: redcap.link/reg_matlab_feb20… #SingleCellAnalysis #NoCoding: redcap.link/reg_scbio_feb202…

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease! Postdoctoral Fellow in Chromatin Biology and Genomics National Cancer Institute, National Institutes of Health See the full job description on jobRxiv: jobrxiv.org/job/national-can… #chromatinbiology #chromatinorganization #epigenomics #generegulation #singlecellanalysis #topoisomerasednasupercoiling #ScienceJobs jobrxiv.org/job/national-can…

Share your answer to the #DrishtiDailyQuiz in the comment section. #CancerTreatment #AIInMedicine #C2SScale #CancerResearch #AIforHealth #GeneExpression #SingleCellAnalysis #ImmuneSystem #DrishtiPCS

Science should not be limited by location or device. With IAS, advanced analytics are available seamlessly on PC, smartphone, and tablet. From gene analysis to multidimensional visualization—tSNE, UMAP, FlowSOM, and beyond—every mode is fully accessible with the same intuitive interface. Whether in the lab, on the move, or across the globe, IAS empowers researchers to explore data, share insights, and accelerate discovery. Science without boundaries. That’s the future we’re building at LifeAnalytics. #LifeAnalytics #IAS #AIforScience #DrugDiscovery #Bioinformatics #DataVisualization #SingleCellAnalysis #FutureOfScience #AnywhereAnytime

Ever wonder what the butterfly effect looks like in molecular biology? 🦋 With #LiveSeq you can follow the same living cell over time — from tiny molecular flutter to dramatic transformation. From correlation ➝ causation. #SingleCell #LiveSeq #CellBiology #MolecularBiology #ButterflyEffect #Causation #InnovationInScience #LifeSciences #Transcriptomics #SingleCellAnalysis #CancerResearch #SystemsBiology

Out Now! Single-cell analysis of genetically minimized Salmonella reveals effector gene cooperation in vivo bit.ly/46p9PQo #SingleCellAnalysis #Salmonella #Microbiology

📣Call for Reading: #Review Digital PCR for Single-Cell Analysis by Weibo Fang, et al. mdpi.com/2079-6374/14/2/64 #PCR #SingleCellAnalysis #microfluidic #biosensors #mdpi #openaccess

🔹 PhD Opportunity – 1–2 Positions in Analytical Chemistry (Funded) 📍 Uppsala University 🇸🇪 🔗 phdscanner.com/opportunities… 🧑‍🏫 Supervisor: Prof. Ingela Lanekoff (ingela.lanekoff@kemi.uu.se | 46 18 471 36 93) 📅 Deadline: September 10, 2025 ✅ Specialization: Analytical Chemistry with focus on single-cell analysis and mass spectrometry imaging ✅ Research: Develop innovative analytical methods using nano-DESI, electrospray ionization, and tandem MS for molecular characterization of biological samples ✅ Environment: International & interdisciplinary collaborations across biology, pharmacy, medicine, SciLifeLab ✅ Training: Work with state-of-the-art instrumentation, experimental design, molecular annotation strategies & data analysis ✅ Duties: Research, PhD coursework, and up to 20% teaching ✅ Requirements: MSc in Chemistry (preferably Analytical Chemistry), strong English skills, experience in mass spectrometry, metabolites, lipids is meriting 📌 Employment: Full-time, temporary (as per Higher Education Ordinance Ch. 5 § 7) 📧 Contact: Prof. Ingela Lanekoff (ingela.lanekoff@kemi.uu.se) #PhDOpportunity #UppsalaUniversity #Sweden #AnalyticalChemistry #MassSpectrometry #SingleCellAnalysis #ResearchCareer #FundedPhD #Chemistry

🚀 Massive Microbubbles → Robotic Microtools Happy to share our latest in Nature Communications — a breakthrough in microbubble technology that create numerous bubbles as programmable, biocompatible, high-throughput micro-robots for nano- & bioassembly. For a decade, microbubbles held promise for nanomanufacturing & biomedicine, but hit barriers in scalability, efficiency & biocompatibility. We’ve made breakthrough: ✨ Key advances: • Low-intensity, light-controlled microbubble arrays • Deterministic assembly of nanocrystals, exosome vesicles, living cells • Monitoring of dynamic bacterial metabolism & drug response 🔬 Applications: Drug & antibiotic screening | Single-cell omics | Nano/biofabrication | Soft microrobotics 📄 Read: nature.com/articles/s41467-0… 🎥 Watch: static-content.springer.com/… #NatureCommunications #MicrobubbleAssembly #OptoElectrochemistry #Nanotechnology #Biosensing #SingleCellAnalysis #DrugDiscovery #Nanoassembly #Bioengineering