#Autoimmune encephalitis and PNS are diagnosed using autoantibodies. We aim to develop a multiplex assay detecting >70 autoAbs in one test with minimal sample volume, reducing costs and speeding diagnosis. Supported by @auvergnerhalpes #RareDiseases #regionauvergnerhonealpes

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Agreed. Here's an idea, based off the recent Yale work on autoAbs in LC. Do a trial of antibody depletion using Protein A immunoadsorption,which specifically targets IgG (and especially IgG4,which mRNA vacs bias you towards).Deplete by 50% or so and check for symptom improvement.

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Could be a unification of both my position and that for some patients. Large emerging literature on chronic infections going uncleared due “acquired errors of immunity” cytokine disrupting autoabs

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Autoantibody mistakes appear “permanent” once acquired; it’s part of why I think chronic diseases not getting better once acquired are a callsign of autoabs as mechanism (for long COVID, ME/CFS, MS, lupus - there is already clear evidence, but I believe this is likely much broader and applies to other mystery diseases that “don’t go away” like ALS, Parkinson’s, schizophrenia - could also make such diseases curable with plasma cell depletion as some are exploring).

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Longer-term loans have appeared for years in ABS deals, but financiers are including a larger portion of them in collateral pools, albeit with safeguards, as more lenders expand their maximum allowed term. hubs.la/Q04kKH4K0 #autofinance #autolending #autoabs #autoloans

U.S. economic growth likely will cool in 2026 as consumer spending weakens and global oil prices influence activity and demand, according to Fitch Ratings. hubs.la/Q04kDLrx0 #autofinance #autoabs #autosales

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While we ran these arrays - something special I’d missed. Most autoantibodies are private. Categorical enrichments happen. Known! (Fig 3I). But private autoabs within an ontology … another layer entirely (Fig 3J). Suggests (mechanistic?) individuality beyond shared abs!

Orbital fibroblasts produce GAGs when activated by the autoabs, resulting in oedema and orbital muscle hypertrophy. A similar process occurs in the skin, particularly on the shins for some reason, giving a waxy and thickened appearance.

Graves Disease. Autoimmune hyperthyroidism; autoantibodies generated against TSH receptor, which bind & mimic TSH. ⬆️T3 & T4, ⬇️TSH due to negative feedback. Causes goitre (enlarged thyroid) and opthalmopathy (autoabs also bind to TSH-like autoantigens on orbital fibroblasts).

Breakthrough study! Autoabs to IFN-I are increasingly recognized as a cause of severe infections, but why do these arise? this study shows that IFN-I autoabs result from loss of T-cell tolerance w B-cell autoimmunity in GC reactions. Thanks to the entire team for this effort!

Heterozygous #FOXN1 variants can impair thymic development in a manner that promotes the selective emergence of neutralizing auto-Abs against type I #IFNs. -> thereby predisposing affected individuals to severe #ViralInfections. Monitoring these auto-Abs may support personalized therapeutic strategies for affected patients. Learn more about it, here 🔗 doi.org/10.1111/pai.70314 . #pai_journal #openaccess #originalarticle #thymicdevelopment #autoAbs #typeIIFNs #severeviralinfections #autoantibodies #Abs #IFNα2 #IFNω #heterozygousvariant #FOXN1gene

Immune-altering autoabs occur in the young but become more common with age. If involved in failed melanoma surveillance (assuming young and old melanomas have similar immunogenicity) you’d expect the same autoab preceding the tumor in both populations as a risk factor

All key arrears and default metrics for China’s auto ABS collateral deteriorated sharply in 4Q25, while RMBS performance remained broadly stable. Read more: ow.ly/b04g50YwenN #AsiaPacific #China #AutoABS #ABS #RMBS #StructuredFinance

Australian auto asset-backed securities (ABS) performance remained stable in 4Q25, with arrears, losses and recoveries tracking near historical averages. Read more: ow.ly/NuoI50Yv6FE #AsiaPacific #Australia #AutoABS #ABS

Our New preprint: Proteome-wide PhIP-Seq of CSF & serum across two independent neurological Long COVID cohorts reveals no shared CNS autoantibody signature. Reactivities are sparse, heterogeneous, and largely patient-specific. medrxiv.org/content/10.64898… #LongCOVID #neuroLC #autoAbs