Interested in Urology Cancers, biomarkers and drug development.

Joined December 2019
734 Photos and videos
Tom Powles retweeted
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JUST IN: @US_FDA approves combo HIF2 inhibitor Belzutifan PD1 inhibitor Pembrolizumab in adjuvant Kidney Cancer. Approval based on LS022 trial co-led with @tompowles1 presented @ASCO #GU26 adding another approval to @NobelPrize story with @kaelin_lab @DanaFarber @DanaFarber_GU ! Onward ! Great day for patients ! #HIF2 #oncology #labubu dailynews.ascopubs.org/do/li… blog.dana-farber.org/insight…
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Tom Powles retweeted
🆕 article in press: GLP-1 receptor agonist use and cancer risk in obese nondiabetic adults doi.org/10.1016/j.annonc.202…
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New data in @Annals_Oncology: A target trial emulation of >229K obese, nondiabetic adults shows GLP-1RA use is associated with a 41% reduction in obesity-associated cancers compared to lifestyle modifications alone (HR 0.59). - Congratulations to Aparna Kamat, Arthur Hsu, @pedroramirezMD & entire @MethodistHosp team annalsofoncology.org/article… @SGO_org
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Tom Powles retweeted
Truly humbled and delighted to join European Urology as a Consulting Editor. It is a privilege to contribute to a journal that stands at the forefront of urological science and clinical practice.
We're delighted to welcome Yao Zhu, MD, PhD, as a Consulting Editor for European Urology. A leader in genitourinary oncology, robotic surgery, and translational research, Professor Zhu brings extensive clinical, research, and editorial experience to our team. Welcome aboard! #EuropeanUrology #Urology #Oncology
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Tom Powles retweeted
Our #ASCO26 podcasts are now available in Spanish! Thanks to the magic of AI translation, @tompowles1 and @brian_rini speak fluent (sort of) Spanish. Listen to our podcast on PROTEUS here and all ASCO podcasts on all major podcast platforms. @_SEOM @OncoAlert spotifycreators-web.app.link…
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Metrics from #ASCO26 via @OncoAlert @ASCO
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Tom Powles retweeted
CTLA-4 inhibition provides clinically meaningful benefit that is worth the extra toxicity in RCC
67% Yes
33% No
33 votes • Final results
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Does CTLA-4 inhibition benefit RCC patients?
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Bulumtatug fuvedotin toripalimab similar combo to EVP (Nectin4/MMAE/PD1) : response rates of 83% and 12 mnth PFS looks similar to EVP. But would this beat DV toripalimab (a SOC in China 🇨🇳) or EVP. With payload cross resistance I’m not sure we can sequence these. #ASCO26 #BladderCancer @OncoAlert @ASCO
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EXCEED #ASCO26: LY4101174 = More data on Nectin4/Topo1 ADCs in 86 patients with pretreated advanced UC . RRs 20% is lower than expected while haem tox was high. Efficacy and toxicity balance doesn’t support further development. Yesterdays data (LY405 same payload/target) has ⬆️ efficacy and is a preferential agent for R3 development IMO. Not all ADCs with matching target and payload are the same.@OncoAlert
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Durvelo-2 #ASCO26 Zele (Nectin-4/MMAE peptide) pembro. Response rate =55% (n=~50). The toxicity maybe attractive but with a similar profile to EV. Cross trial comparison of toxicity is hard with small numbers. @y_loriot said the EV program is on hold waiting for further follow up. With widespread global use of EVP its would be very hard to start the planned R3 with platinum chemotherapy as the control. It’s hard to see a clear path forward IMO. Perhaps its future is in triplet combination?
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POTOMAC QOL: A year of durvalumab with BCG shows a delay in DFS and is FDA approved #ASCO26 . Here durvalumab appears to have little effect on QOL. We know ICIs have a ~10% rate of life changing toxicity (~10% @BethN01 ) which ⬇️QOL. New tools/methods are needed to unpick the details for patients.
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Tom Powles retweeted
Breaking news #ASCO26 Adding Talazoparib to enzalutamide significantly ⬆️ rPFS 👉 HR 0.48 in pts w/ mCSPC (mAPMS) #prostatecancer w/ HRRm 👉 @NEJM paper tinyurl.com/vkvra8cd 👇 @ASCO @oncoalert @urotoday @PCF_Science @OpenMedicineHQ
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The #OncoAlertTopTweet Day 2 of #ASCO26 🚨from the Podium to your feed with Dr. Elizabeth Nally @BethN01 from Barts Cancer institute🇬🇧 discussing Abstract 4512 : Decision regret and toxicity perception following adjuvant pembrolizumab in renal cell carcinoma. @veda13k @scocmem @b_szabados @Naveed_Sarwar @tompowles1 @montypal @crisbergerot @DrChoueiri 🇺🇸 @hoperugo 🇺🇸 @matteolambe 🇮🇹 @TiansterZhang 🇺🇸 @CathyEngMD 🇺🇸 @stolaney1 🇺🇸 @montypal 🇺🇸 @tompowles1 🇬🇧 @brian_rini 🇺🇸 @cdanicas 🇪🇸 @NiuSanford 🇺🇸 @amerseburger 🇩🇪 @GlopesMd 🇺🇸 @Icro_Meattini 🇮🇹 @PGrivasMDPhD 🇺🇸 @DrYukselUrun 🇹🇷 @nataliagandur 🇦🇷 @ElisaAgostinett 🇧🇪 @HHorinouchi 🇯🇵 @realbowtiedoc 🇺🇸 @to_be_elizabeth 🇮🇹 @UOzkerim 🇹🇷 @Erman_Akkus 🇹🇷 @yekeduz_emre 🇹🇷 @p_ciracimd 🇮🇹 @DrVilmaPBarcia 🇪🇸 @DraMartinezLago 🇪🇸 @DrMirallas 🇺🇸 @GaiaGriguolo 🇮🇹 @MarioBalsaMD 🇪🇸 @scocmem 🇬🇧 @AmandaNizamMD 🇺🇸 & @weoncologists 🇺🇸
A Great Start to Day Two of #ASCO26 and no better way to start than our @OncoAlert 🚨from the Podium to your feed with Dr. Elizabeth Nally from Barts Cancer institute🇬🇧 discussing Abstract 4512 : Decision regret and toxicity perception following adjuvant pembrolizumab in renal cell carcinoma. In this multicentre London study of 104 patients with RCC treated with adjuvant pembrolizumab, decision regret was uncommon (13%) after a median 30-month follow-up. Regret was driven primarily by long-term, patient-perceived significant or life-changing toxicities rather than disease recurrence or CTCAE-graded severity. Permanent endocrine and musculoskeletal toxicities were associated with the highest regret. Patient-informed toxicity assessments outperformed CTCAE criteria in identifying regret, highlighting the importance of patient education and shared decision-making. #KidneyCancer Elizabeth Nally @veda13k @scocmem @b_szabados @Naveed_Sarwar @tompowles1 @montypal @crisbergerot Pinging OncoAlert Faculty @brian_rini 🇺🇸@declangmurphy 🇦🇺 @KidneyCancer 🇺🇸 @salvolarosa @silkegillessen🇨🇭 @APCCC_Lugano @RenuEapen 🇦🇺 @nataliagandur 🇦🇷 @seanmcbride 🇺🇸 @DrJaVallejo 🇪🇸 Pinging our ASCO Pulse Faculty @DrChoueiri 🇺🇸 @hoperugo 🇺🇸 @matteolambe 🇮🇹 @TiansterZhang 🇺🇸 @CathyEngMD 🇺🇸 @stolaney1 🇺🇸 @montypal 🇺🇸 @cdanicas 🇪🇸 @NiuSanford 🇺🇸 @amerseburger 🇩🇪 @GlopesMd 🇺🇸 @Icro_Meattini 🇮🇹 @PGrivasMDPhD 🇺🇸 @DrYukselUrun 🇹🇷 @nataliagandur 🇦🇷 @ElisaAgostinett 🇧🇪 @HHorinouchi 🇯🇵 @realbowtiedoc 🇺🇸 @to_be_elizabeth 🇮🇹 @UOzkerim 🇹🇷 @p_ciracimd 🇮🇹 @DrVilmaPBarcia 🇪🇸 @DraMartinezLago 🇪🇸 @DrMirallas 🇺🇸 @GaiaGriguolo 🇮🇹 @MarioBalsaMD 🇪🇸 @scocmem 🇬🇧 @AmandaNizamMD 🇺🇸 & @weoncologists 🇺🇸
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Tom Powles retweeted
A HUGE Round of thanks! The #OncoAlert5k 🚨Continues to Grow year after year, with a lot of new faces but also all the regulars🏃‍♂️ Thank you all of the great support! WE ARE INDEED ALL OncoAlert!! @Icro_Meattini @BalazsHalmosMD @alitimumab @MikeSerzanMD @barrosonco @DrVilmaPBarcia @DonjetaZeqa @crisonco @santcancela @golbretas @fedenichetti @crisonco @CathyEngMD @BenWestphalen @OncBrothers @graokane @realbowtiedoc @GaiaGriguolo @COR2EDMedEd @mirrorsmed @amerseburger @DrMirallas @ravikanesvaran @fabioturco92 @salvolarosa @KidneyCancer We Totally missed @to_be_elizabeth @ElisaAgostinett @nataliagandur and @CentralParkWMD @Latinamd @CathyEngMD @LaurenMachos @JooMouta2 @drteplinsky @matteolambe and many more but we look forward to seeing them at the 5k in Madrid🇪🇸 or during OUR HOMECOMING 5k in my HOME of San Antonio Tx🇺🇸for #SABCS26
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Tom Powles retweeted
Dear Colleagues at #ASCO26 A Great pleasure to bring you from the podium to your feed our amazing GU Faculty Dr. Tom Powles 🇬🇧presenting EV302 With 3.5 years of follow-up, EV plus pembrolizumab continues to demonstrate durable survival benefits over platinum-based chemotherapy in previously untreated locally advanced or metastatic urothelial carcinoma. Median overall survival reached 33.6 months versus 15.9 months with chemotherapy, without new safety signals. Notably, two-thirds of patients achieving complete response initially had partial responses, often converting after additional treatment cycles, highlighting the importance of treatment duration in maximizing long-term outcomes. asco.org/abstracts-presentat… @tompowles1 @MichvdHeijden @MattGalsky @y_loriot @IyerGopa @JCensits @mar_nataliya @CVulsteke @KalaSridh @shilpaonc @OncoAlert @nataliagandur @scocmem @AmandaNizamMD @WeOncologists @montypal @DrDanielHeng @apolo_andrea @DrChoueiri @PGrivasMDPhD @TiansterZhang @neerajaiims @amerseburger @Silke_Gillessen @tompowles1 @AndreaNecchi @cdanicas @AOmlin @crisbergerot @HHammersMD @ravikanesvaran @sonpavde @drenriquegrande @scserendipity1 @EfstathiouEleni @BraunMDPhD @brian_rini @weoncologists
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Tom Powles retweeted
We teleport to Lugano to bring you a recap of the ctDNA data from Keynote-564 presented at #ASCO..
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