Obesity doesn't just affect the waistline—it reshapes the brain. Emerging evidence suggests chronic metabolic overload disrupts neurovascular coupling, blood–brain barrier integrity, cerebrospinal fluid dynamics, and myelination, creating conditions that may accelerate neurodegeneration. As obesity and neurological disorders rise in parallel, understanding these interconnected pathways could reveal new strategies to protect brain health across the lifespan. #Neuroscience#Obesity#BrainHealthnature.com/articles/s42255-0…
Interleukin-17 (IL-17 and its receptor, IL7R) is emerging as a key mediator in many immune-related diseases. Today @SciImmunology a superb review
science.org/doi/10.1126/scii…
Better data for better medicines: a path to data-driven medicines regulation
nature.com/articles/d41573-0…
This new Comment article highlights how the EU medicines regulatory system is becoming more data-driven
@EMA_News
Review @SciImmunology
The transcriptional and epigenetic regulation of macrophage differentiation, specialization, and activation in health and disease
science.org/doi/10.1126/scii…
This Review in the May issue discusses how microglia integrate signals from central and peripheral immune cells in neurodegenerative disorders, highlighting therapeutic targets and biomarkers nature.com/articles/s41573-0…rdcu.be/fk3uL
Muscle talks to the brain. 💪🧠
Exercise triggers myokines & myometabolites that boost cognition, while inactivity sends harmful signals that impair brain function. This muscle–brain crosstalk shapes behavior and resilience to aging and neurodegeneration. @WuTsaiAlliancesciencedirect.com/science/ar…
A new amazing resource for drug target explorations with genomic data was released today @Nature:
A massive meta-analysis GWAS for 249 NMR-quantified metabolites in UK Biobank and Estonian Biobank across 619,372 individuals👇