Associate Professor, Purdue University (via India - U. Maryland, College Park - UCLA - UCSD/HHMI). Having fun following Fic proteins. @mattoolab.bsky.social

Joined August 2018
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Thanks to @Hypothesisfund, esp. Scout Joseph Mougous, for valuing & investing in my science. I applaud the vision behind creation of HF & am truly honored to be selected as part of this inaugural class of awardees. 🙏🏽 @LifeAtPurdue @PurdueScience @PurdueBiochem @PurdueBiolSci
What is the biological significance of a previously unrecognized post-translational modification? #Grantee @MattooLab’s curiosity-driven question aims to elucidate the role of #GMPylation! 🎉Congrats Dr. Mattoo! bit.ly/HFgrants 🙏#HFScout Joseph Mougous @LifeAtPurdue @UW
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Dr. Seema Mattoo retweeted
25 Jun 2025
🗳️Results of the 2025 ASBMB election are in! ☑️Please join us in congratulating our new president, secretary, Council members and committee members. ow.ly/biaV50WgiA8
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Dr. Seema Mattoo retweeted
Out Now! Host AAA-ATPase VCP/p97 lyses ubiquitinated intracellular bacteria as an innate antimicrobial defence bit.ly/4jebHzK #Microbiology #Antimicrobial #Bacteria
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Dr. Seema Mattoo retweeted
Big congrats to #HFScout Joseph Mougous on his new position at @Yale!
We are delighted to welcome Joseph Mougous to the Microbial Sciences Institute. An international leader in microbiology and HHMI Investigator, Mougous joins the faculty @YaleMicroPath later this year. medicine.yale.edu/news-artic…
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Dr. Seema Mattoo retweeted
This #InternationalWomensDay and everyday, we celebrate the inspiring women in our HF community who continue to push boundaries and shape a brighter future for science.💫
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The God of War joins the innate immunity lexicon. ARIES Domains: Multi-motif interferon (IFN) inducing signaling domains found in all known IFN-inducing pathways. febs.onlinelibrary.wiley.com…
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In the #PurdueOneHealth Series, here’s coverage of our collaborative effort focused on protein misfolding and disease. @PurdueBiolSci @PurdueBiochem @PurdueLifeSci
Part 2️⃣ in the #PurdueOneHealth Series 👇 A project involving @PUCancerInst researchers is looking at how the intricate process of folding proteins can go awry, leading to errors that are found in #cancer and other diseases. purdue.link/1H.pt2
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Dr. Seema Mattoo retweeted
It's Valentine's Day and Professor Tony Hunter has been "going steady" with Salk for 50 years now. On Feb 21, join us in celebrating his half-century legacy at the Salk Institute. Lab alumni, colleagues, and other luminaries will share their science, memories, and tributes to this legendary cancer biologist. Learn more about Hunter's remarkable legacy: salk.edu/news-release/celebr…
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Dr. Seema Mattoo retweeted
29 Jan 2025
I am thrilled to say that our work is now online @CellCellPress ! I've analysed protein structures for quite some time, but @Robb_Mallik, who co-led this work, took these analyses to yet another level - 🧵👇 sciencedirect.com/science/ar…

26 Jan 2024
🔥Cell biology meets structuromics🔥 1000s of proteins assemble co-translationally but we don't know why🤷‍♂️ @Robb_Mallik found it’s all about protein 🧩structure🧩, with implications for #gene_expression, #proteostasis, #evolution & #mRNAlocalization 🧵👇 biorxiv.org/content/10.1101/…
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Our collaboration w/ Greg Anderson lab, describing work of my postdoc @RadhikaBhaumik. We delineate the roles of pili in establishing S. maltophilia biofilms, notorious for nosocomial infections. @PurdueBiolSci @PurdueBiochem sciencedirect.com/science/ar…

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Dr. Seema Mattoo retweeted
Is this real, or is it excessive AI hype? New paper claims that an AI foundation model achieves experimental-level accuracy in predicting gene expression even in previously unseen cell types." I'll read the paper, but don't believe it for a second nature.com/articles/s41586-0…
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“Future scientific innovation requires the transformative power of philanthropy.” We're honored to be mentioned in this PNAS editorial as an example of philanthropy's role in supporting the next great scientific breakthroughs. pnas.org/doi/10.1073/pnas.24…
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I'm so thrilled to (re)join the team @scifri. Ira gave me my first gig in journalism 20 years ago‼️ So this feels like a homecoming. It also feels like a really good time to be focused on bringing people trustworthy (and fun) science news.
7 Jan 2025
We’re proud to announce that @flichtman is joining @iraflatow as a host of Science Friday! sciencefriday.com/articles/f…
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Dr. Seema Mattoo retweeted
🙏🙏🙏Honored and humbled. Huge Congratulations to @Bio_BRU and a big thank you to @sistonheat for all her hard work. Looking forward to the exciting journey ahead!
Thrilled to announce Dr. Mehdi Mollapour @MedMol as our new CSSI President (2025–2026) and Dr. Adrienne Edkins @Bio_BRU as President-Elect (2027–2028)! Huge thanks to Dr. Lea Sistonen @sistonheat for her dedicated service as Immediate Past President. bit.ly/4gCGEfB
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Dr. Seema Mattoo retweeted
Thrilled to announce Dr. Mehdi Mollapour @MedMol as our new CSSI President (2025–2026) and Dr. Adrienne Edkins @Bio_BRU as President-Elect (2027–2028)! Huge thanks to Dr. Lea Sistonen @sistonheat for her dedicated service as Immediate Past President. bit.ly/4gCGEfB
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It was spring 2020. I was a professor and had recently learned I’d successfully been awarded early tenure. At the tail end of a series of talks at other universities, a colleague had invited me to give a seminar at a stellar department that was an unusually great fit for my research - they were interested in recruiting me there. I was about to fly there a second time with my husband to more carefully consider moving my lab, husband, and then-6yo son to a place they’d never been. Two days before our trip, COVID shut down the country. I remember thinking, “am I really going to leave my perfect stable life where my family is happy…to move to a place I know so little about, to a house sight unseen, to a department I just visited for the first time ever?” The thing I remember most clearly from that time is the email I wrote to my new department chair. I said that every time I wonder if I’m crazy to take this leap, I remember how my parents moved to this country when I was 5 and my sister was 7. They left a comfortable life to a place where none of their professional credentials were recognized. My dad was the chief engineer on an oil tanker and retrained here as a software engineer, rose up in the ranks, and became senior manager in a lucrative tech company. My mom was a dentist who had to repeat 4 years of dental school entirely over in the states so she could do the work she already had infinitely more professional experience in than her classmates. Due to exchange rates and fees, any money set aside was decimated, and they started basically from scratch as they built up the skills to build a new life. All for the promise of uncapped potential for their kids. The decision I was grappling with in the aggressive safety of my life was a drop in the bucket of the leap of faith my fearless parents took for their kids. So when offered the position, I told my new department chair that by comparison, this felt easy - I accepted the offer without reservation. While I didn’t stay there long, I soon co-founded a company that employs even more people than my academic lab did, working on some of the most important problems at the leading edge of biotechnology. I feel so fortunate this country welcomes intellectuals and founders but also all those whose potential we cannot predict to create what we cannot imagine. America is the promise of what is not yet realized. Built by those who are not yet famous. The unique mix of creativity and talent and ambition and fearlessness from every corner of the world. It’s such a humbling and awe-inspiring idea we have the opportunity to fight for.
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Merry Christmas! I ended the work year fighting a bad cold, w/ a cough that lingered on forever… so much so that my family gave me the gift of lozenges this Xmas 🤣 Gives a whole new meaning to Deck the “Halls”! Wishing you happy holidays & good health! @LifeAtPurdue
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Congratulations, @JayAkridge!!
Congratulations to Jay Akridge, professor of @PurdueAgEcon on being awarded the 2024 Hovde Award of Excellence! Dr. Akridge made an impact in every role he held at @LifeAtPurdue, including as dean of @PurdueAg. As dean he supported #PurdueExtension and rural Indiana communities, embodying the university’s land-grant mission. ag.purdue.edu/news/2024/12/j…
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Mattoo lab closing out the semester with our holiday party. Thank you to this amazing group and all our supporters/well wishers who make lab and research so meaningful & fun! @LifeAtPurdue @PurdueBiolSci @PurdueBiochem
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My @PurdueBiolSci BIOL 533 #MedMicro class did an outstanding job on their posters today! Students were assigned articles extending from class content. They also designed a "next experiment" based on their article & evaluated if #AI helped refine the expt. @LifeAtPurdue
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