@maxewilkinson profile picture
Max Wilkinson @maxewilkinson
Joined October 2016
  • Tweets 158
  • Following 190
  • Followers 3,010
38 Photos and videos
The Wilkinson Lab is open for science! @MSKCancerCenter 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
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annnnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great) wilkinsonlab.bio
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covercovercovercovercovercovercovercovercovercovercover this is terrifically exciting (Also please dw, the central dogma is still very much intact, this is just a bit of a funky spin on it)
Science Magazine
@ScienceMagazine
3 Oct 2024
The central dogma of molecular biology states that genetic information flows from DNA and RNA to protein, with reverse transcription converting RNA to DNA. In the pursuit of understanding how bacteria defend themselves from viral infection, two groups have found alternative pathways to making genes from RNA that did not previously encode proteins. Learn more this week in Science: bit.ly/3ZO7tI1
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PS if someone in the Boston area spots a spare printed copy in their department tearoom could they please steal it for me 😊😊🙏🙏 (steal one for yourself first of course)
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Max Wilkinson retweeted
Brady Cress@bradyfcress
30 Aug 2024
Such a crazy discovery. I think this captures the reaction of the audience while watching @maxewilkinson present this at the Symposium on the Immune System of Bacteria.
Max Wilkinson@maxewilkinson
29 Aug 2024
My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/
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My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/
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(P.S. eternal thanks as ever to @bradyajohnston for his #MolecularNodes plugin to #Blender3D. It makes molecular animation so much fun)
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Lots more in the paper (#cryoEM etc!) doi.org/10.1126/science.adq3… Big thanks to coauthors @_David_Li @algao8 Rhiannon Macrae and @zhangf Please also check out @shsternberg @stephentang23 related work - we come up with similar models, but it'll be exciting to resolve the differences!

Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA

Reverse transcription has frequently been co-opted for cellular functions and in prokaryotes is associated with protection against viral infection, but the underlying mechanisms of defense are...

science.org
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Max Wilkinson@maxewilkinson
11 Jul 2024
Nils's incredible work is finally out, amazing work on a multi-talented protein by a multi-talented postdoc! It was a joy to use Dari @kimanius 's new Blush algorithm in #RELION to solve the cryoEM structure of this 40 kDa RNA complex
Nils Birkholz@NilsBirkholz
10 Jul 2024
👋🏻 I'm absolutely glee-ridden to finally see our study on the RNA- and DNA-binding anti-CRISPR repressor Aca2 published in @Nature. 🥳 This unassuming little helix–turn–helix protein packs quite the punch! 🧶👇🏻 rdcu.be/dNl45
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Max Wilkinson retweeted
Akos Nyerges@AkosNyerges
17 Jun 2024
In our newest preprint, • we explore the effects of synonymous genome recoding, and • construct & troubleshoot a synthetic 57-codon E. coli genome using multi-omics, editing, and laboratory evolution. 1/n
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Max Wilkinson retweeted
Alexander Bates@as_bates
18 May 2024
The fly has a full #connectome, basically a directed weighted graph. But what are its connection ‘signs’, excitatory/inhibitory? We move towards this answer, predicting transmitters from EM! w/@BobQubit, vid @amyneurons, 1/n Published @CellCellPress: cell.com/cell/fulltext/S0092…
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very gratifying to see the importance of this part of U4 snRNA, but also kinda sad to learn that exome sequencing has historically excluded such essential small RNAs by default
Nicky Whiffin@nickywhiffin
8 Apr 2024
Replying to @nickywhiffin
But what is this RNA? RNU4-2 encodes the U4 snRNA component of the major spliceosome. The 18 bp region maps to two critical structures thought to control the positioning of the U6 ACAGAGA sequence (image credit to @Seb_Fica - SNV positions in red, insertions as arrows) 7/9
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(also having second thoughts about calling that region "quasi-pseudoknot", although it seemed like a good idea at the time)
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Max Wilkinson retweeted
Nicky Whiffin@nickywhiffin
8 Apr 2024
Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in @GenomicsEngland ??? I didn’t initially either, but here is the story of RNU4-2 🧵1/9
Yuyang Chen@quenchentin
8 Apr 2024
Thrilled to share our latest discovery on a spliceosomal snRNA gene causing neurodevelopmental disorders: medrxiv.org/content/10.1101/… Thank you to everyone who contributed; it’s been a phenomenal effort to collaborate with clinicians and researchers for what would help many families!
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Max Wilkinson@maxewilkinson
20 Feb 2024
go R2!! 🐦‍⬛🐦‍⬛ this is a very lovely study 😍
Collins Lab@CollinsRNPLab
20 Feb 2024
Bird bird bird, bird is the word! Is the secret to safe gene addition a retroelement in birds? We repurposed the avian R2 element to insert transgenes into human cells (and more!) using RNA-only delivery 🪶 a thread 🧵 nature.com/articles/s41587-0…
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