SITUATION DETECTED: The city of Rio de Janerio has post-trained a model. Based on Qwen 7/2, Rio 3.5 Open 397B adds SwiReasoning on top of the base Qwen model — a framework that dynamically switches between standard chain-of-thought and latent-space reasoning, guided by entropy-based confidence signals, so the model only "thinks out loud" when it needs to and otherwise reasons silently in hidden space for better token efficiency.

Introducing the Fusion API, the smartest compound model in the market. Fusion achieves Fable-level intelligence at half the price. How it works 👇

The city of Rio has post-trained Qwen 3.5 397B to be an even better model foundation model by incorporating SwiReasoning (claiming Pareto superiority!): huggingface.co/prefeitura-ri… #DigitalSovereignty #OpenModels #AI #genAI #FOSS

Seriously if I were British, I’d make a page or YouTube channel just for this. Amelia teaching the world about British contributions. Real reasons to be proud of your ancestry and history. Never be ashamed of being great.

The leadership at Wipro OTOH seems convinced that the real opening for India is in "Small Language Models for specific applications", while giving cursory ceremonial lip-service to "multilingual AI". 🤷‍♂️ ndtv.com/video/india-s-ai-pl….

Alibaba Qwen3.7 slowly fading into irrelevance at the frontier due to proprietary stance. In it's place we have Minimax M3 and... *checks notes* Rio 3.5 397b, made by the municipal IT company of Rio de Janeiro's city government. huggingface.co/prefeitura-ri…

US State dept readout of Jaishankar-Rubio call indicates sharp differences: "Secretary Rubio stressed that all commercial vessels should immediately comply with orders from U.S. forces as they seek to uphold peace and security in the Strait.  He underscored that violations of the U.S. blockade and the illicit transport of Iranian oil will not be tolerated.

All of these were reported over the past month: • A new pancreatic cancer drug, daraxonrasib, that roughly doubles survival in late-stage disease • A precision lung cancer drug, lorlatinib, that kept 55 percent of patients progression-free after 7 years, versus 3 percent on the old drug • A prostate cancer drug, talazoparib, that halves the risk of progression • An endometrial cancer drug, dostarlimab, where 58 percent of patients hadn't progressed after 4 years, versus 16 percent on chemo alone • An early-detection blood test, the NHS Galleri test, that quadrupled cancer detection but missed its main goal • An mRNA cancer vaccine that halved the risk of melanoma recurrence when added to Keytruda • The most effective weight loss drug so far, retatrutide, which cut body weight by about 28 percent • The first in vivo gene editing therapy, which cut hereditary angioedema attacks by 87 percent from a single injection • A one-time gene edit, VERVE-102, that lowered LDL cholesterol by 62 percent • A feat of pharmaceutical synthesis that raised enlicitide's manufacturing yield 14-fold using engineered enzymes • A functional cure for hepatitis B, bepirovirsen, that cleared the virus in about 20 percent of patients • The discovery that human cells can swap chromosome-sized DNA through nanotubes • An ancestor of CRISPR, VIPR, found in bacteriophages, that silences genes without cutting DNA • A preventive Covid-19 pill, ensitrelvir, that cut symptom risk by 67 percent after exposure • The first PROTAC drug, vepdegestrant, which destroys a disease-causing protein rather than blocking it Every month, Niko and I write a round up digging into the latest news in biotech and medicine, and this month's was astonishing. We share some thoughts on what's responsible for this progress and what it means for science in the future.

In light of the news of the US export licence on Anthropic's Fable/Mythos, I'm re-upping my op-ed, in which I argued that India must seek digital sovereignty in the form of open AI models because access to proprietary models can be revoked at any time. pranesh.in/press/mythos-self…