Gastrointestinal medical oncologist @clevelandclinic. Tweets are my own.

Joined November 2010
150 Photos and videos
Smitha Krishnamurthi retweeted
Great session! With lots of hopeful collrectap cancer research for future ASCOs! Better patient outcomes and clinical guidelines for care Wonderful way to end #asco26 @ASCO
🙏🙏 @ASCO @Betzabe100 @KristenCiombor We had a wonderful time creating this CRC IO Education Session; case debate/voting/Q A too! Thank to Stacey Cohen and our moderator, Chris Lieu a ASCO-FASCO pro! Thank you to the ASCO AV team who were so helpful patient with us! 🙏🙏🤝🤝
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Smitha Krishnamurthi retweeted
Grateful to have an incredible multidisciplinary team to be able to offer liver transplant to our patients @ChaseWehrle @CleClinicMD
Liver transplant for metastatic #CRC seemed like a pipe dream few years ago and now we have great data pointing to clear benefit for highly selected and treated pts, led by @kgnairmd @FAucejo @SKamath_MD @smitha42 @DrEstfan et al #ASCO26
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What an incredible career and legacy. Rest in peace Dr. Habr Gama.
Sad to hear of the passing of Dr.Angelita Habr Gama. She was an icon & impacted the lives of so many rectal cancer patients. Thanks to her pioneering work & that of others who followed in her footsteps, we have Watch & Wait as an option for #rectalcancer! RIP Dr. Habr Gama #crcsm
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Smitha Krishnamurthi retweeted
1/ASCO 2026 is days away and your feed is filling with "abstracts/presentation I'm most excited about." My pick is ...probably on nobody's list. The whole story is about one dose. Give me 90 seconds. It may worth a read.
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Smitha Krishnamurthi retweeted
#ASCO26 has released most abstracts. I will break down GI cancer-related abstracts to five tables: Important studies Interesting studies Important negative studies Novel agents Practice re-affirming studies Abstracts that have not been released but are eagerly anticipated: RASolute-302, EMERALD-3, CIRCULATE (AIO), Episode-3, BREAKWATER update, PUMP. Please see the tables below for the first two tables (important studies, interesting studies). More to come. @OncoAlert @jgong15 #GIcancer
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Smitha Krishnamurthi retweeted
Excellent Leadership opportunity at @ClevelandClinic Program Director for Thoracic Medical Oncology careercenter.asco.org/job/76… @ASCO
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👀This novel study using methylation scores to identify exposures in patients with #Colorectal #Cancer finds an association with the herbicide picloram and #EOCRC- a potential new risk factor worthy of study! Picloram was introduced in the US in 1963. Congrats to authors @VHIO
Why are we seeing so much early-onset colorectal cancer? The correlation with pesticide exposure and its epigenetic signature, adjusted for all known risk factors. (doesn't establish cause and effect) nature.com/articles/s41591-0…
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Congratulations @MyriamChalabi ! So happy to see your bold, inspiring work recognized! 👏🏽👏🏽👏🏽Love the video too! 😊 Innovators in Science Award: 2026 Grand Prize Winner Myriam Chalabi youtu.be/ch_Zhvf4GJY?si=OMhm… via @YouTube
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Smitha Krishnamurthi retweeted
Out of press! Amivantamab (fully human, bispecific IgG1 monoclonal antibody) that targets EGFR and MET Monotherapy in Chemorefractory RAS/BRAF Wild-Type Metastatic Colorectal Cancer: Results From OrigAMI-1, an Open-Label, Phase Ib/II Study | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JCO… @ASCO #colorectalcancer #cancer Enroll to #Origami2 (NCT06662786) and #Origami3 (NCT06750094) Vanderbilt University Medical Center
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Very sad to see this. I remember Asal speaking so passionately about the need for clinical trials with the goal of extending the benefit of immunotherapy to all patients with colorectal cancer. @CathyEngMD @ctycka @FightCRC
After a valiant battle with cancer, we lost my former staffer Asal Sayas. She had many friends and admirers, including me. While battling her own cancer, she worked on President Biden’s Cancer Moonshot to expand access to clinical trials. My heart is with her loved ones.
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Short term data but incredible
Actual slides from $RVMD 1L PDAC Darax Chemo
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Smitha Krishnamurthi retweeted
Phase 1/2 data re: @AACR #AACR2026 Daraxonrasib Gem/nab-paclitaxel (N=40) by Dr. Wolpin: ORR = 58% and 6M OS = 90%. RASolute 302 to be presented at @ASCO #ASCO2026. RASolute 303 is now open for 1st line. #pancreaticcancer @PanCAN @Rev_Medicine #cancer #cancerresearch @OncoAlert
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Smitha Krishnamurthi retweeted
Metastatic pancreatic cancer in the @ASCO plenary! Finally! Our patients are waiting
Daraxonrasib phase 3 (RASolute 302) data to be presented at #ASCO26 plenary session on May 31st.
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Smitha Krishnamurthi retweeted
🚨🚨🚨 RASOLUTE-302 Ph3 is POSITIVE "Daraxonrasib demonstrated a median OS of 13.2 months versus 6.7 months for chemotherapy, with a hazard ratio of 0.40 (p < 0.0001)".... WOW! AMAZING news for patients with #PancreaticCancer The RAS Revolution is ON!! ir.revmed.com/news-releases/…
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Congratulations @rachnatshroff ! So well deserved!
A $1M gift is advancing cancer research and compassionate care at the University of Arizona. Rachna Shroff, MD, is the inaugural Duval Endowed Professor for GI Oncology, leading clinical trials that drive new treatments and improve patient outcomes. More: tinyurl.com/453kettm @rachnatshroff @UAZCancer
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Smitha Krishnamurthi retweeted
“You’re too young” is not a diagnosis. Colorectal cancer is now the leading cause of cancer death for men and women under 50. It is one of the only major cancers still increasing in incidence. This is not a future problem. This is already here. A few things that matter: • Screening works. Average-risk screening starts at 45, earlier if you have risk factors. • Symptoms in young people are real and should never be brushed off. • New rectal bleeding, constipation, diarrhea, bowel habit changes, abdominal pain, or unexplained anemia are warning signs. If symptoms are new or persistent, push for evaluation. If you’re eligible, get screened. If someone you know is being dismissed, advocate for them. wsj.com/health/healthcare/co…
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Smitha Krishnamurthi retweeted
As of today, the United States has officially left the World Health Organization. We’ll look back on this as a grave error. Health threats do not respect borders, and weakening global cooperation makes Americans less safe.
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Congrats @cagirlinchi and @manjuggm and @colontown on this work! Great time saving option for patients. So happy I got to see you both at #ASCOGI26 !
Thanks to everyone who stopped at the @colontown #5FU Freedom! poster & shared your thoughts! Your enthusiastic support for our work is much appreciated! The best part about #GI26 is meeting new & old friends! Check out Poster D14 if you haven’t already! #CRCSM
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Smitha Krishnamurthi retweeted
Colorectal cancer research at #ASCOGI26: Patients are more willing than physicians to trade some survival for better quality of life—like oral-only treatment or fewer side effects. Poster by @DanaFarber’s @ThejusJay. asco.org/abstracts-presentat…
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Smitha Krishnamurthi retweeted
#GI26 BREAKWATER Encorafenib Cetuximab FOLFIRI met primary ORR endpoint (64.4% vs 39.2% for 1L FOLFIRI/Bev). Data immature on everything else, but I’m going to be offering it next week to one of my pts unfortunately with early recurrence after adjuvant FOLFOX. #BRAFV600E
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