๐งฌ
#ScienceSaturday
โ Why does immunotherapy work so well for some cancers, but often fail in
#glioblastoma, one of the most aggressive brain cancers?
โก๏ธ A new study in
@NatureCancer suggests the answer may depend less on how many DNA mutations a tumor has, and more on the tumorโs โcell state,โ or what the cancer cells are actively doing.
โก๏ธ Researchers studied 181 glioblastoma samples from patients treated with immune checkpoint blockade, a type of immunotherapy designed to help T cells recognize and attack cancer.
โก๏ธ They found that glioblastomas in a mesenchymal, or MES, state were linked to better survival after immunotherapy. These tumors appeared more โimmune-visible,โ with higher levels of HLA class I, a signal that helps T cells recognize abnormal cells, and more T cell infiltration.
โก๏ธ Surprisingly,
#tumor mutational burden, a marker often used to predict immunotherapy response in other cancers, did not predict better outcomes in this glioblastoma group.
โก๏ธ The study also revealed a possible escape route: after
#immunotherapy, some tumors shifted away from the MES state toward non-MES states, which may make them less recognizable to the immune system and more resistant to treatment.
๐ง Why this matters: Glioblastoma has been extremely difficult to treat, and checkpoint immunotherapy has mostly been disappointing in this disease. This study suggests that future trials may need to look at a tumorโs RNA โactivity pattern,โ not just its
#DNA mutations, to identify patients who may be more likely to benefit.
โจ Big takeaway: In glioblastoma, the tumorโs current โstate of mindโ may help predict whether immunotherapy can see it, attack it, and make a difference.
Read more here:
nature.com/articles/s43018-0โฆ
@Nature @DanaFarber @Harvard @harvardmed @MassGenBrigham @broadinstitute @IBMResearch @DanaFarberNews @EAChiocca @JackYGhannam