Honorary Medical Oncology Consultant @royalmarsdennhs | NIHR Clinical Lecturer @TurajlicLab @TheCrick @rmresearch_ @ICR

Joined November 2010
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Scott Shepherd retweeted
JUST IN: 2 Belzutifan (HIF2 inhibitor) phase III trials POSTIVE for Primary Endpoint in Renal Cell Carcinoma: LITEPSPAK022 (adjuvant) LITESPARK011 (metastatic, post PD1). BIG NEWS for GU Oncology Kidney Cancer patients! tinyurl.com/2hywykhk tinyurl.com/mwawkbz7
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I was very happy to present some of the updated data from LITESPARK-004 clinical trial at #IKCSEU25 - a great way to kick off #VHL awareness month !@VHLAlliance
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Very fortunate to work alongside such a talented bunch! @royalmarsdenNHS renal unit @TurajlicLab representing at #IKCSEU25 👊🏼 ✌🏼 thanks for having us @KidneyCancer
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#IKCSEU25 great session on the promise of neoadjuvant Rx @ZaydTippu Leading the charge - excited for all the developments to come in the space ☄️
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#IKCSEU25 and we’re off!
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Very excited to see publication of this personalised neoantigen vaccination in ccRCC in UK kidney cancer awareness week. Congratulations to the authors and look forward to the next steps of its clinical development
1/ JUST IN: an 8 year #kidneycancer journey now published in @Nature: “A personalized neoantigen vaccine generates anti-tumor immunity in high-risk renal cell carcinoma”. A trial of #RCC vaccine, led together with first author @BraunMDPhD @YaleCancer and #PatrickOtt #DerinKeskin #CatherineWu @DanaFarber nature.com/articles/s41586-0… @DanaFarber_GU @OncoAlert @DFCI_NeoVax
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Wonderful news for patients with VHL and sporadic RCC
Today is a very special day for patients with RCC : CHMP as approved BELZUTIFAN both for VHL disease associated RCC and for advanced renal cell carcinomas (following CPI and 2 VEGFR TKIs) Data presented at @myESMO and published in @NEJM
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Scott Shepherd retweeted
Today is a very special day for patients with RCC : CHMP as approved BELZUTIFAN both for VHL disease associated RCC and for advanced renal cell carcinomas (following CPI and 2 VEGFR TKIs) Data presented at @myESMO and published in @NEJM
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As a farmer’s son and an oncologist here’s a review article I’m fully on board with - brilliant stuff!
15 Nov 2024
We just published a review of lessons farmers have learned for how to control pesticide resistance from evolving, and how to apply those to oncology to prevent cancers from evolving therapeutic resistance: bit.ly/48OfFdX
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Scott Shepherd retweeted
Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/n medrxiv.org/content/10.1101/…
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Great to contribute to this initiative and I look forward to the ongoing discussions. Many thanks to @IKCCorg for sponsoring the event and to Grant Stewart and Axel Bex for organising
Our Chair, Dr Michael Jewett, was pleased to participate in the International Neoadjuvant Renal Cancer Consortium Meeting in Amsterdam on October 24-25. The IKCC was pleased to support expert clinicians and scientists committed to addressing an unmet need in the treatment of kidney cancer patients. It was a great opportunity to continue discussions from a meeting in January with experts representing urologists, medical oncologists, radiologists, pathologists and clinician scientists, as well representatives from patient organisations. #KidneyCancer
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Scott Shepherd retweeted
Phase 1 data on the HIF-2a inhibitor casdatifan presented by @DrChoueiri at #ENASymp24. Among 86 pts with advanced solid tumors, the toxicity profile appeared favorable (mostly low grade anemia, fatigue, hypoxia), with an encouraging preliminary activity (ORR 25-34%). @DanaFarber
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Scott Shepherd retweeted
12 Oct 2024
⭐️PhD opportunity alert ⭐️ Want to work in a fun, supportive environment targeting really novel models of melanoma metastasis? Pls retweet! crukcentre.manchester.ac.uk/…
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🤯 very cool
1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in @ScienceMagazine. science.org/doi/10.1126/scie… Here is a summary of what we discovered!
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Landmark decision by #NICE @NHSEngland approving reimbursement of Belzutifan for management of VHL-related tumours. Wonderful news for patients and their carers; 1st approved systemic therapy for VHL! @vhl_uk_ireland @VHLAlliance england.nhs.uk/2024/09/first…

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🚨🚨 Register now for the 2024 Crick Cancer Research Symposium - awesome program of speakers highlighting recent advancements in our understanding of cancer. Abstract submissions close 06-SEP-2024 🚨🚨 tinyurl.com/ycxhnnja @TheCrick @TurajlicLab
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Scott Shepherd retweeted
May is here, and so is VHL Awareness Month! Here's what's coming your way over the next few weeks: 🌟 Shareable social media content to educate and inspire. 🚶‍♀️ VHL Awareness Walk promo ahead of the big day on May 18th! 👋 Updates on what we're working on behind the scenes
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Amazing work, check it out! Congratulations @DrJonLim and all in the @ReiseSousaLab
Delighted 🤩 to see our work on how Vit D regulate gut microbiome 🦠 to facilitate cancer immunity finally out in @ScienceMagazine! Kudos to the formidable @giampazolias, Team @ReiseSousaLab & all collaborators for getting it to the finish line! Curious to hear what you think👇
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Important and inspiring tour de force @TheCrick lecture from Uğur Şahin. The age of mRNA therapies has arrived !
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