Online Now: A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer dlvr.it/TSn7r3

Ever wonder why we decide to build a new microscope and how we go about it? For the last lecture this semester of the graduate microscopy class Na, Gokul, and I teach at Cal, I spoke on our developing iSOAR microscope, a swept HILO design with adaptive optics and structured illumination. iSOAR is designed to produce the petabytes of high resolution 5D videos of subcellular dynamics in zebrafish we need to train the multimodal vision models at the heart of our Cell Observatory Initiative. We still have some work to do, but the scopes are coming along nicely. It's an exciting time at the Observatory, so if you're experienced and looking for a job in zebrafish transgenics, ultra-high throughput image processing, or the development of 5D spatiotemporal foundation models for interpreting the insane dynamic complexity of living matter, we'd love to hear from you. (sup@berkeley.edu, betzige@janelia.hhmi.org).