Excited to share our new paper in Nature Immunology! 🦠🔬 nature.com/articles/s41590-0… We uncover a central role for intestinal stem cells in defending the tissue against Salmonella infection. A huge thanks to all collaborators and team members who made this work possible!

Check out our latest pre-print on @biorxivpreprint ! We show that the intestinal MHC II self-ligandome is spatially compartmentalized across villus, crypt, and immune niches, and is dramatically rewired during injury toward damage-associated self-antigens. doi.org/10.64898/2026.03.18.…

The SMR 2025 Annual Congress (Amsterdam Oct 25-28) covers basic, preclinical & translational melanoma research. It is a very enjoyable conference with top faculty and now improved with ample opportunity for young investigators to learn & network. Join us! smrcongress.org

Excited to share our study in @SciImmunology dissecting the immune landscape of psoriatic arthritis (PsA)—with a new finding: immunoproteasome overactivity drives treatment resistance🧵 Led by Reut Tzemach,Chamutal Gur,@TgSanPhan,Eyal David & team. (1/11) science.org/doi/10.1126/scii…

We are excited to share our new study @Cancer_Cell identifying Zeb2 as a master genetic switch controlling the tumor-associated macrophage (TAM) program. Led by @FadiSheban, @TgSanPhan, @CuriousKX & @FlorianIngelfi1. (1/20) cell.com/cancer-cell/fulltex…

✨It’s going to be a fantastic meeting, there are still some spots left. Sign in by the end of the month for earlybird rates #antibodies #complement #scientificconference #therapeuticantibodies @roumenina @ZivShulman @DahanLab @carovinuesa @MOUQUETHugo1 @javid_lab @NussenzweigL

Our latest preprint is out! 🚨We discovered that intestinal stem cells actively fight bacterial infections. Learn more about it in our new study by @SachaLEBON in collaboration with @matanhofree biorxiv.org/content/10.1101/…

If you’re interested in our protocols for cell doublet quantification and imagestream analysis from our #BiCE paper, or if you have a bispecific engager of your own that you’d like to test, check out our new protocol from @DahanLab with @PoratZiv published in @STARProtocols 🫧

💡Exciting news! Our latest research is now published in @CellCellPress: "Therapeutic potential of co-signaling receptor modulation in hepatitis B" 🚀🧵(1/11) 🔬Using mouse models, we traced the development and fate of dysfunctional CD8 T cells, showing that hepatocellular priming induces a unique dysfunctional program distinct from classical exhaustion. (2/11) 🌟Key finding: Blocking co-inhibitory receptors like PD-1, CTLA-4, and LAG-3 showed minimal effect. However, activating 4-1BB and OX40 transformed dysfunctional CD8 T cells into antiviral effectors. (3/11) 📊Prolonged antigenic stimulation leads to a self-renewing, long-lived population of CD8 T cells with a unique transcriptional profile, including progenitor/stem-like and tissue-resident memory cells. (4/11) 📌In chronic settings, only 4-1BB maintained expression across all dysfunctional subsets, making it a prime candidate for therapeutic intervention in chronic HBV. (5/11) 🧬In HBeAg chronic patients, 4-1BB activation showed the highest potential to rejuvenate dysfunctional CD8 T cells, making it a prime candidate for therapeutic intervention. (6/11) 🔑Our findings suggest that targeting all dysfunctional T cells, rather than only stem-like precursors, holds promise for treating chronic HBV infection. (7/11) 💡Mechanistic insights: 4-1BB activation enhances effector molecule expression and CD8 T cell cytotoxicity, driving robust antiviral responses. (8/11) 🔍This study provides a comprehensive atlas of the co-signaling receptors induced in dysfunctional HBV-specific CD8 T cells and reveals potential targets for therapeutic intervention. (9/11) 👏Huge thanks to our incredible team and collaborators, especially @frarro1, @Chiara_Laura91, Micol Ravà, @CaroCKrueger, @FichtMaria, Keigo Kawashima, and @CristianBecc who co-led the study. This work wouldn't be possible without you! (10/11) 📖Dive deeper into our study and its implications for HBV treatment. We're excited to hear your thoughts and engage in discussions! Full paper here: authors.elsevier.com/sd/arti… 💬📚 (11/11) @SanRaffaeleMI @MyUniSR @ERC_Research @AIRC_it @EMBO_YIP @ArmeniseHarvard

Outstanding award presentation by @yuval_shap while receiving the EPHAR-EACPT Young Investigator Award in Translational Pharmacology. Congrats Yuval, we are very proud of you 👏🏻 🏆 @EACPT @Sys_Immunology @WeizmannScience

I am honored to receive the 2024 Rappaport Prize in Biomedical Sciences for the development of new cancer immunotherapies. A big thank you to my mentor and PI, @DahanLab, my amazing labmates and collaborators, @WeizmannScience , and the @Sys_Immunology department 🙏