In our lab, hardcore biochemistry meets physics. And coffee. We are investigating DNA replication through single molecule loupe @MPI_Biochem.
Joined May 2019
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23 Nov 2023
🚨Incredibly happy to share that our #ERCCoG project #ChromoMemInMotion is funded @ERC_Research. 🍾 We are grateful to the reviewers and panel members ! This was only possible thanks to amazing work of lab members past & present @MPI_Biochem & @TU_Muenchen. A dream come true🙏♥️
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9 Apr 2025
🚨New preprint🚨We developed a transverse flow imaging approach to directly visualize bacterial replisomes challenged by topological barriers and discovered a fast rotational mode of replisome operation. Fantastic work by Thomas Retzer and Hamdan Lab! tinyurl.com/replisomerotate
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9 Apr 2025
If you have not already, make sure to check-out two fantastic recent preprints from the Patel and Wang labs on the same topic investigated using magnetic tweezers and angular optical trapping:
doi.org/10.1101/2024.10.14.6… and doi.org/10.1101/2024.10.09.6…
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9 Apr 2025
We are grateful to TUM and @MPI_Biochem for their support and Margot Riggi for figure help. This would not have been possible without early support from SFB863, forces in biomolecular systems, and the European Research Council.
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Congrats on the Nomis Award, Elena @LabConti ! Her #NOMIS project aims to discern the structure and biochemical nature of #mRNPs in the brain throughout the #mRNA life cycle.
❗️nomisfoundation.ch/projects/…
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23 Oct 2024
Out today in @NAR_Open from @cees_dekker lab!!
*DNA supercoiling enhances DNA condensation by ParB proteins*
doi.org/10.1093/nar/gkae936
Together with @Aless322 (and @Gruber_Lausanne ) we show the interaction between partition complex proteins (ParB) and supercoiled DNA!
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21 Oct 2024
Thrilled to share our new work @biorxivpreprint:
biorxiv.org/content/10.1101/…
Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live cells. We reveal genome chromatin is essentially replicated from regions with greater nucleosome motions. 1/2
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Read the latest publication from Danny Nedialkova’s lab and collaborators! In their latest work, they show that increased translation during the maternal-to-zygotic transition sensitizes maternal mRNA decoding rates to #tRNA supply.
❕embopress.org/doi/full/10.10…
@ddnedialkova #RNA
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Read the latest @Nature Perspective of Kikuë Tachibana's lab:
❗️rdcu.be/dVOZh
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1 Oct 2024
A tour de force from Carl Wu's lab @JohnsHopkins .- lead author postdoc Robert Louder: Molecular basis of global promoter sensing and nucleosome capture by t... sciencedirect.com/science/ar…
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11 Sep 2024
We are hiring! Position open for a new assistant professor in the Department of Biophysics & Biophysical Chemistry in @HopkinsMedicine . Considering all areas in experimental and computational biophysics. Please spread the word. apply.interfolio.com/154014
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Duderstadt_lab retweeted
7 Aug 2024
What makes for a great DNA-PAINT experiment? How does the fluorescent dye affect the image quality? And how can we use this to extract the most out of our samples?
Check out our paper in @NatureMethods to see what state-of-the-art DNA-PAINT can do for you!
doi.org/10.1038/s41592-024-0…
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Duderstadt_lab retweeted
7 Aug 2024
We are excited to share new mechanistic insights into DNA replication fidelity! How does human DNA Polymerase Epsilon recognise and proofread errors made during synthesis? 🧬
Read @NatureSMB nature.com/articles/s41594-0…
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5 Aug 2024
Cool video of eukaryotic dna replication! #molecularnodes
5 Aug 2024
Here's a render of a full eukaryotic replisome carrying out DNA replication. This was built using real .pdb data from @buildmodels
I used this to make my latest video: (youtu.be/lv89fSt5jBY)
But now I want to do a quick works cited 🧵 (1/ ?)
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27 Jun 2024
Glad to present our latest results published today in @Nature revealing the activation mechanism of the AAA -dependent IS21 transposase. Congrats to all the authors!
@CIB_CSIC, @CSIC
Full story here:
rdcu.be/dLZgB
nature.com/articles/s41586-0…
and brief summary below 👇🧵
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26 Jun 2024
Thank you so much for the warm welcome!😍 It has already been such a stimulating and rewarding experience at @mpi_ie , looking forward to the years ahead!🧑🔬🧫🔬🧬
25 Jun 2024
We are so happy to welcome Valentin Flury (Follow: @ValeFlury) as the newest Group Leader of Max Planck #Freiburg. 🥳
His lab at the @mpi_ie aims to understand #chromatin dynamics and plasticity throughout the cell cycle.
📰INTERVIEW with the #NewPI: ie-freiburg.mpg.de/5849404/2…
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12 Jun 2024
Now online! Single-molecule imaging reveals the mechanism of bidirectional replication initiation in metazoa dlvr.it/T8BfVZ
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17 May 2024
How does Mcm10 activate an origin of replication?
Find the answer in our paper published today in @NatureSMB. Congratulations to Sarah Henrikus & our fantastic lab! 🥳🎉
rdcu.be/dIdI4
Great collaboration with Marta, Allie and John from @DiffleyLab @TheCrick
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