Next week, we’re back with two unique development talks: mouse gastruloids 🐭 with @KStapornwongkul and turtles 🐢 with Agáta & Barbora. Mark your calendar—you won’t want to miss this!
🗓️ Dec 5, 12:30 EST / 18:30 CET / 17:30 UTC 🕥
🌟 New Paper Alert! 🚨
How does a developing embryo know where to place somite boundaries? 🦴🐟
Our latest study authors.elsevier.com/a/1kATe… in @Dev_Cell reveals a missing piece of the puzzle involving ERK oscillations and the segmentation clock (nature.com/articles/s41586-0…)
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This project eventually bud off the published work which showed how to convince vertebrate embryos lacking a molecular clock to make somites: nature.com/articles/s41586-0…
Unexpectedly, clock, a shortlived transcriptional repressor, lowers ERK activity by stabilizing ERK posphatases!
thanks all in @OzbudakLab and beyond who ended up collaborating with me and teaching me new things in this project as it came to its present form: authors.elsevier.com/c/1kATe…
Ontario friends I am visiting next week! On Wednesday I'll be speaking in Toronto at the MaRs building (1PM in 15th floor seminar room). On Thursday I'm speaking at McMaster (4-5 in MDCL). I'll talk about what happens when flies taste bacteria & swarm intelligence in stem cells!
The desynchronization of cell divisions in early mammalian embryos—once seen as a random process—instead plays a crucial role in ensuring robust development, shedding light on how embryos maintain precision despite biological noise, researchers report in Science. bit.ly/3Y523WH
Congratulations to Denis Duboule @Duboule for being awarded the 2025 ISDB Harrison Medal for his contributions to the understanding of gene regulation, particularly the Hox gene family, and their spatial collinearity in vertebrates 🎉🎉🏅 developmental-biology.org/ne…
🧪A team of researchers, led by @HelenFarrants & @ERSchreiter, developed a new way for engineered protein biosensors & bright, fluorescent Janelia Fluor dyes to work together, creating a new biosensor for measuring physiological signals in live animals.➡️janelia.org/news/new-biosens…
Finishing your PhD and interested in the Physics of Life? We are in the midst of our annual search for new Fellows. We are looking for both theorists and experimentalists ready for a bit more independence than a regular postdoc. To learn more: biophysics.princeton.edu/opp…
New preprint: We have developed an integrated pipeline to i) image gastruloids in toto with dual-view 2-photon🔬, ii) quantitatify cell and tissue-scale patterns of gene expression and morphometric features, iii) interact with the data in @napari_imaging. biorxiv.org/content/10.1101/…
I am on the job market this year for tenure-track positions in Canada and the US! My research program will investigate genetic and biological pathway bottlenecks in organ development that result in congenital anomalies, using animal models and microscopy imaging 1/2
1/ Thanks Rita! The @naturemethods comment follows from my “Confessions” talk last February and is motivated by my desire to recruit financial backers, AI collaborators, and highly motivated data scientists and biologists to join us for our “Cell Observatory” mission.
youtube.com/watch?v=OhCVBx_Z…
A quick and thought-provoking read on the state of fluorescence microscopy and what it will take to tackle the most complex questions in biology from Eric Betzig. Highly recommended reading!