How do distal enhancers control transcription dynamics in living cells? Check out our latest work published in @MolecularCell!! We show that the dynamic assembly and disassembly of TF clusters at enhancers are a major source of transcriptional bursting. cell.com/molecular-cell/full…

Huge thanks to Mounia for a fantastic seminar! So many exciting unpublished stories!!

Cohesin activity accelerates the homology search biorxiv.org/content/10.64898…

Online Now: RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription dlvr.it/TT0yzt

来週月曜6/15にMounia Laghaさんのセミナーを定量研にて開催します。最新のRNA可視化解析について話してもらう予定です。所外からのご参加も大歓迎です！

Our TEAD1 condensate paper is now online at Nature Cell Biology! TEAD1, despite being a transcription factor, forms condensates at the heterochromatin. We found that it actually served as depots to sequester excess TEAD1. Nature is full of surprises! nature.com/articles/s41556-0…

My lab @UTD_Biology is hiring a research technician who studies the mechanisms of nuclear transport and organization using the Drosophila brain as a model system! jobs.utdallas.edu/postings/3…

RNAP at the apex: Cryo-ET unveils the torsional tango between plasmid DNA and double-helix-melting proteins dlvr.it/TSxKTl

Finally out in @Cellcellpress! Proteins with long intrinsically disordered regions (IDRs) are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. cell.com/cell/fulltext/S0092…

Excited to share the first pre-print from our lab!! Check it out here! biorxiv.org/content/10.64898… We found that many RNA-binding proteins understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.

Our paper on the cryo-EM structures of Bxb1 has finally been published in Molecular Cell after a two-year journey through Science and Molecular Cell! Thanks to a great collaboration with @ChrisWFell, @omarabudayyeh, and @jgooten. sciencedirect.com/science/ar…

Excited to host Mounia Lagha (IGMM, Montpellier) IQB on June 15 (Mon)! Everyone is welcome, including non-IQB members. Hope to see you there!!

Check out our new work in Cell Systems! Much of cellular biochemistry is organized by biomolecular condensates, but what mechanisms control their distribution throughout the cell? And is this mesoscale organization important for function? link: bit.ly/4vsl845

We are currently recruiting a PhD student for my lab at the Institute of Quantitative Biosciences, University of Tokyo. Please get in touch if you are interested and feel free to share!

Hello world, meet 1,000× Expansion Microscopy. 1,000,000,000× expansion by volume! A gel that starts at a few centimeters will then expand to the volume of an Olympic swimming pool. biorxiv.org/content/10.64898… In our new bioRxiv preprint, work carried out between MIT and UMG, led by Helena Hu in collaboration with scientists from the labs of @eboyden3 Ed Boyden, Silvio Rizzoli, and myself, we present Thousandfold Expansion Microscopy. By enlarging biological specimens across multiple rounds of expansion, molecular-scale features, as small as the distances between adjacent amino acids, can be visualized with conventional optical microscopes. Democratizing super-resolution microscopy.

Active RNA synthesis patterns nuclear condensates: Cell Systems cell.com/cell-systems/fullte…

Nifty work on plasmid chromatinization from @stergachislab ! "plasmids are indeed capable of recapitulating nuclear genome-encoded chromatin architectures, ... However, plasmids consistently adopt a heterogeneous and incomplete chromatin architecture relative to nuclear-encoded chromatin fibers, and surrounding sequence context plays an integral role in modulating whether a plasmid-encoded regulatory element will recapitulate nuclear genome-encoded chromatin architectures."

Fun2Fountain: Investigating transcription-replication conflicts in 3D genome dlvr.it/TSjmtw

For those who read our group’s Cas13 lncRNA study last year, we wanted to share an update: The corrected version of the study is now published in Cell Genomics.

Now out in @NatureBiotech ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones. nature.com/articles/s41587-0…