Sunrise run at #IKCS25 with amazing colleagues ✨ No better way to come together, recharge, and stay grounded in why we do this work. Grateful for this community and for every step we take to push kidney cancer care forward. #GUonc#KidneyCancer
Great talk by @MdArpita#ucsf at #IKCSNA25 succinctly summarizing options in the challenging setting of IO resistance in RCC. We are looking ahead to earlier implementation of HIF2a blockade and earlier access to trials for our patients. @KidneyCancer
From the May issue: 'Presence of Tertiary Lymphoid Structures and Exhausted Tissue-Resident T Cells Determines Clinical Response to PD-1 Blockade in RCC brnw.ch/21wSSDz
By Miya Hugaboom, @lena__wirth, Kelly Street, @nruthen16, Michael Atkins, Catherine Wu, @BraunMDPhD
Interested in myeloid cell anti-tumor immunity? I’ll be presenting at @theNCI Rising Scholars Seminar Series on 17 Apr our work on Fc-optimized CD40 Agonistic Antibody and TLS formation and induction of Systemic Antitumor Immunity cassyni.com/events/Eg84FXZjL…
(1/3) Check out our multicenter, IIT of sitravatinib nivolumab after ICI in patients with metastatic ccRCC shorturl.at/qGWgy This trial was terminated early (14 of 88 planned) but built upon our group’s experience with sitravatinib led by @PavlosMsaouel
Federal #kidneycancer research funding drops from $50 million to ZERO after 57% cut to CDMRP. All but 12 of the 35 disease research programs saw funding eliminated for 2025, including the Kidney Cancer Research Program. More about the impact on our blog. bit.ly/4hoXnCq
UPDATE 3/12: Last night the House voted to cut 57% of federally funded medical and cancer research through the CDMRP. Vote moves on to Senate and, if passed, to be signed into law by the President.
More details: kidneycancer.org/protect-fed…
🚨Protect Federal Funding for Kidney Cancer Research🚨
Right now, @CDMRP is facing a devastating 57% cut that directly impacts federal #kidneycancer research funding. Tell your reps to vote in support of continued funding.
Take action NOW - bit.ly/4hoXnCq
Interesting to consider a ‘very favorable risk’ subgroup of ccRCC patients and the role of VEGFR targeted therapies here. How will HIF2a blockade perform in these patients?
Congrats to @dsahil320 Sahil Doshi for this retrospective analysis of outcomes on first-line therapy in >100 patients with #chromophobe rcc. Looking forward to seeing longer term follow-up in patients in the doublet cohorts. @MVossMD@NazliDizman@OncHahn@dreaknezevic
Big news for bladder cancer in US!
“On December 15, 2023, the Food and Drug Administration (FDA) approved enfortumab vedotin-ejfv in combination with pembrolizumab for patients with locally advanced or metastatic urothelial cancer (la/mUC).”
JUST IN: @US_FDA approved belzutifan (HIF2 inhibitor) in advanced renal cell carcinoma (RCC) following PD1 and VEGF inhibitors!
A great day for the field and a new option for our Kidney Cancer patients!!!!
Via @ASCO#FDAAlerts@OncoAlert
Study presented at @myESMO#ESMO3 by @AlbigesL
Happy to share our findings at #IKCSNA23! In our single-institution retrospective cohort, no evidence of superiority of either IO/IO or TKI/IO in #kidneycancer 1L tx with regard to PFS2, including in groups w/ sarcomatoid features, BAP1 mutation, or deep RECIST response.
Zanzalitinib with activity in refractory RCC with manageable safety profile even in those patients who had previously received cabozantinib @montypal@DrChoueiri@KidneyCancer
Belzutifan vs everolimus in pretreated RCC #ESMO23: 25% ⬆️ in PFS, OS HR = 0.88 (95% CI 0.73-1.07) with RR=23% vs 3% & 25-45% ⬆️ in time to ⬇️ QOL. Tox of note: hypoxia. This looks attractive in VEGF/IO refractory disease instead of evero. Combos earlier in the disease awaited.