The Moraga group studies cytokines and their central role in immune regulation. We combine protein engineering, structural biology & immunology in our research
Joined May 2019
- Tweets 100
- Following 139
- Followers 147
- Likes 393
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Moraga Lab retweeted
7 Mar 2024
After a hard year, I’m glad to see this finally over the line. A real team effort from @YiboJin @scott_d_gardner @TomasVoisin and others from @LabMoraga. As always, amazing data collection support @eBIC_Diamond #cryoem nature.com/articles/s41467-0…
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Moraga Lab retweeted
7 Mar 2024
Disease-associated variant in IL6ST gene encoding for gp130 led to increased flexibility including motion within the cytokine-binding core (IL-6 and IL-11) and increased distance between extracellular domains
nature.com/articles/s41467-0…
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7 Mar 2024
Excited to share our newest full collaboration with @BubeckLab. We provide structural insights that help explain how mutations in gp130 that do not disrupt cytokine binding cause signaling defects and immunodeficiencies in humans. doi.org/10.1038/s41467-024-4…, @UoDCellSigImm
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Moraga Lab retweeted
2 Aug 2023
🚨2 Yr Postdoc Available🚨
Jointly supervised with @scienceadvocacy working on normal and pathological HSCs, cytokines, malignancy, clonal expansion. Come and join us at the newly-formed @CBR_UoY @YBRI_UoY
Apply here 👇👇👇jobs.york.ac.uk/vacancy/post…
Pls retweet and DM!
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Moraga Lab retweeted
24 May 2023
Differential functional coupling in Gp130-JAK complexes expands the plasticity of the interleukin-6 signaling axis biorxiv.org/cgi/content/shor… #bioRxiv
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25 May 2023
Ever wonder why ancestral cytokine receptors, like Gp130, bind multiple JAKs, and whether the identity of the GP130-JAK complex instructs specific responses? Check our new work, in a full collaboration with the @PiehlerLab, for some answers
biorxiv.org/cgi/content/shor…
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Moraga Lab retweeted
24 May 2023
📜State-of-the-Art📜
Molecular and cellular factors determining the functional pleiotropy of cytokines
🖋️ By Alison McFarlane, Elizabeth Pohler and Ignacio Moraga from @dundeeuni
🔗 buff.ly/3pWOAme
#cytokinesignalling #endosomessignalling
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Moraga Lab retweeted
13 May 2023
So excited for this session, I couldn’t sleep! Cytokines, engineering, structures, and therapies.
Not a session to miss!
10:15 AM-12:15 PM room 102AB
11 May 2023
Attending @ImmunologyAAI this week and love cytokines? @CytokineSociety: Modulating Cytokine Activity through Structural Knowledge – Saturday; 10:15 AM – 12:15 PM; Room 102AB. Organized by @DrJuanLMendoza with lots of cool cytokine engineering @SpanglerLab @Regeneron
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Moraga Lab retweeted
17 Apr 2023
Interested in interleukin-6 and how you can therapeutically block its pro-inflammatory activities? See our latest review, just published in @NatRevImmunol — great team work together with @Lab_Jenkins, Stefan Rose-John @kieluni and Jens Moll/Jürgen Scheller @HHU_de
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Moraga Lab retweeted
9 Mar 2023
Join us for the ICIS-sponsored and organized session at Immunity 2023! Learn how both academic and industry members of ICIS are advancing our understanding of cytokine biology and developing future immunotherapeutics.
Going to AAI? Please join us for the ICIS Guest Symposium "Understanding and Modulating Cytokine Activity through Structural Knowledge" @DrJuanLMendoza Saturday, May 13; 10:15 AM – 12:15 PM Eastern Time in Room 102AB
cytokinesociety.org/understa… via @httpstwittercomCytokineSociety
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Moraga Lab retweeted
Going to AAI? Please join us for the ICIS Guest Symposium "Understanding and Modulating Cytokine Activity through Structural Knowledge" @DrJuanLMendoza Saturday, May 13; 10:15 AM – 12:15 PM Eastern Time in Room 102AB
cytokinesociety.org/understa… via @httpstwittercomCytokineSociety
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Moraga Lab retweeted
3 Feb 2023
NEW for 2023 on the @SciImmunology website is the dedicated CANCER IMMUNOLOGY block.
🔗➡️bit.ly/Cancer_Immuno
Scroll down to it & check out 6 recent #cancerimmunology papers. More exciting new content is on the way to this space soon!
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#Cancer
L’acidité des tumeurs nuit à l’efficacité des thérapies anticancéreuses, selon une nouvelle étude. Des résultats qui pourraient conduire à une nouvelle génération de traitements d’immunothérapie.
➡️bit.ly/3hLyjNq
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SPOTLIGHT: After showing that tumor-derived lactic acid limited IL-2 signaling, STAT5 phosphorylation, and antitumor activity in the TME, @Inserm @at_Mitralab used directed evolution to identify a pH-selective IL-2 mutein that bound IL-2Rα with [...] 👉 ow.ly/QAse50M3ptF
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Moraga Lab retweeted
Today's #shoutout to #womeninSTEM goes to SILVIA GAGGERO for her @SciImmunology paper w/ @at_Mitralab showing IL-2 is inactivated by the acidic pH environment of #tumors enabling engineering of a pH-selective mutein.
science.org/doi/10.1126/scii…
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Moraga Lab retweeted
14 Dec 2022
A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its binding affinity in low pH environments.
Read more in @SciImmunology: scim.ag/R5
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Moraga Lab retweeted
9 Dec 2022
A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its binding affinity in low pH environments.
Read more in @SciImmunology: scim.ag/O8
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Moraga Lab retweeted
Another straightforward reason why the Warburg metabolism causes immune suppression in the TME
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein science.org/doi/10.1126/scii…
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Moraga Lab retweeted
7 Dec 2022
A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its binding affinity in low pH environments.
Read more: scim.ag/ME @roychoudhurilab @LabMoraga @at_Mitralab @Inserm @Canther_Lille @CamPathology
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