New from the lab: melanocytic lineage–specific #lncRNA interacts with the DDR machinery. Its loss in dedifferentiated #melanoma revealed that these cells repair damage better and are thus sensitive to #Olaparib! 💡
cell.com/iscience/pdf/S2589-…
El @CIMA_unav obtiene la acreditación como Centro de Excelencia #SeveroOchoa
"Refleja el trabajo y la dedicación de todos los profesionales por generar conocimiento de calidad para mejorar la vida de las personas” José Andrés GómezCantero, director general
cima.cun.es/actualidad/notic…
🆕 review with @jp_unfried out in @NatureSMB 🧐. Direct roles of lncRNAs in transcriptional activation. What do we understand about how lncRNAs lure Pol2 and set the stage for RNA production, and what do we still miss? nature.com/articles/s41594-0…
🚀 Excited to share SMART-PTA (miniaturized Primary Template Amplification) a high-throughput single-cell whole-genome amplification method that preserves clonal lineage information while enabling deep genomic and transcriptomic profiling. biorxiv.org/content/10.1101/…#SingleCell#WGS
Big, beautiful trees!!
SMART-PTA for whole-genome transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
biorxiv.org/content/10.1101/…
It’s been a privilege to be part of the 2025 #HealthResearchMeeting. Grateful to @CaixaResearch for supporting our work on uncovering the structural determinants of long non-coding RNAs involved in colorectal cancer development together with @LlorcaLab and @MaiteHuarteLab
🧬 Colorectal cancer is one of the most difficult to treat due to its resistance to therapies.
To improve treatment efficacy, with #CaixaImpulse@LuisaStatello (@CIMA_unav) is developing a therapy targeting the RNA molecules involved in this resistance. 🎯
tinyurl.com/yj8dhnuh
I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, out today in @NatureBiotech: nature.com/articles/s41587-0…. A short tread! (1/n)
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @CellCellPress, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/ar…
Thanks for the invitation to such an inspiring meeting. Excited to join a community tackling the challenges of cancer through innovative science — looking forward to contributing.
A massive thank you to everyone at #CGCecDNA, especially our co-organisers @mischellab, Mariam Jamal-Hanjani and @HowardYChang, and all of our fantastic speakers!
Together we’ll tackle the challenge of extrachromosomal DNA.
We're in the #Gene4Neuro summit in Gene Therapy for Neuro Degeneration and Rare Neurological Diseases, co-organized and hosted by @CIMA_unav , diving into in-depth discussions about #Neuroscience advancement with @JLLanciego@CSuojanen Pablo Sardi @sanofi and many others!
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵biorxiv.org/content/early/20…
Very excited to share our latest work in @MolecularCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. sciencedirect.com/science/ar…
Gracias, Maite, por aportar luz al complejo mundo de los RNAs Reguladores.
Si no has podido venir a la #raciencias, puedes recuperarlo en nuestro canal YouTubeRAC
youtube.com/watch?v=z6ZWl0lz…
Gracias, Maite, por aportar luz al complejo mundo de los RNAs Reguladores.
Si no has podido venir a la #raciencias, puedes recuperarlo en nuestro canal YouTubeRAC
youtube.com/watch?v=z6ZWl0lz…
1/ El ARN nos abrió la puerta a las vacunas contra la COVID-19 en tiempo récord.💉
Las terapias de ARN prometen transformar la medicina, pero… ¿Hasta dónde nos pueden llevar?🤔
4️⃣ investigadores de la red #CaixaResearch nos lo explican:👇
bit.ly/3F6dF6r
Check out our latest paper! A project that started a long time ago with @ElenaGrossi8@CIMA_unav and took an interesting twist with @MartaMontes3, showing how RNA tweaks metabolic pathways during senescence. Big thanks to all the collaborators!