We talk about bsAb revolution coming across the field of oncology - now more of it in classical hematology as well! Letter in big @TheLancet: Time-limited teclistamab in dara-refractory ITP with basically instant platelet normalization 👏 #MMsb bsAbs to the rescue!

🧵A brief thread on #CardiovascularSurgery and #PCI approaches for patients with heparin-induced thrombocytopenia (HIT) 🩸 Happy to share our review on this topic was recently published: mp.pl/paim/issue/article/169… #hemetwitter #hemesky #classicalhematology *not covering aHIT 1/8

Check out our latest episode "The Aquila Study: Blowing Hot Air or a Soaring Success for Smoldering Multiple Myeloma" with @ManniMD1 @ajperissinotti and @Berninini 🦅💨 #myeloma #badblood creators.spotify.com/pod/sho…

Simple concept of GN. It’s all about location! 1. Subendothelial deposits/injury by Ig, immune-complexes, complement, other mechanism leads to influx of leukocytes= inflammation=GN 2. Subepithelial deposits/injury= protected by GBM & endothelial cells=no inflammation=No GN. 1/3

1/6 TPE-FREE MANAGEMENT OF IMMUNE TTP (iTTP) Retrospective study from Austria and Germany ADAMTS13 activity at baseline <10% in all patients Treatment group (TPE-free): 42 acute iTTP episodes in 41 patients received TPE-free management with caplacizumab steroids /- Ritux

A comprehensive review in @BloodJournal on risk stratification/scoring in MPNs ashpublications.org/blood/ar…

Here is our article that defines and disambiguates both #ockhamsrazor and #hickamsdictum for #differentialdiagnosis link.springer.com/article/10… And a blog post with additional information: medicalevidenceblog.com/2024… And tweetorial as promised

Our first RCT on using an LLM on diagnostic reasoning is out! And the results are 🔥🌶️... adding ChatGPT did NOT improve diagnostic accuracy or reasoning, and the AI alone outperformed ALL the humans. What does this mean? A 🧵⬇️ x.com/EricTopol/status/18509…

1/ Challenge accepted. I have run a series of breast mammograms (x-rays), ultrasounds and MRIs through versions of GPT4 and posted the results here previously. Even though it's data contamination to repost images I already used on X, it's an easy bench mark. So how did Grok do on breast radiology? A little better than GPT4v, but not a single diagnosis correct. 👇

🆕 Infographic on Systemic Lupus Erythematosus! • Recognize signs/symptoms of #lupus and when SLE should be on your DDx • Learn what labs to send if you suspect SLE: And don’t forget to ☑️ UA/UPC ratio! 🫘 #RheumTwitter #MedX #MedTwitter #NephTwitter #Rheumatology

Great reminder that Na delivery to distal tubules and aldosterone needed for kaliuresis. - diuretics (including caffeine) increase Na delivery to distal tubules —> k loss - hypovolemia decreases Na delivery to distal tubules —> reduction in K excretion

Pseudo-AKI - some drugs cause an increase in creatinine due to decreased creatinine secretion. Cystatin C will be normal. #KidneyWk

Hey #NeuroTwitter , check out my #neuromuscularbuckets. It's a method to work backward when evaluating patients with neuromuscular disorders. Sometimes you know the patient has a peripheral nerve disorder, but you get stuck on where to go next. That's where the buckets are helpful. Prefilled buckets that localize to one of the six main aspects of the PNS can help you think of diseases/entities that you don't want to miss. If you have a clinical picture of those disease in your mind while thinking through the case, you'll check for certain things you may have otherwise skipped over! A thread... #medsocial30 @NDECinstitute Day 12

Approach to Atrial Fibrillation (Rate vs Rhythm Control) Ref: uptodate, AHA 2023, Mayo IM board review course (Dr Abhishek Deshmukh)

Approach to anticoagulation in atrial fibrillation Anyone using CHA2DS2-VA (omitting sex) to predict risk of stroke?

Approach to Abdominal Aortic Aneurysm (AAA)

This looks great! Here is our version of an approach to HLH/MAS — made with @nickmmark !

1/ I once heard that a fever in the ICU was a "fever of too many origins." Same can be said altered mental status/encephalopathy! We put together a comprehensive approach to these challenging patients for #SeminarsinNeurology A thread with our approach! pubmed.ncbi.nlm.nih.gov/3913…

Attended on our medicine consult service for 1 day Here are 5 teaching points that came up #MedTwitter #FOAMed #HospitalMedicine #NewsYouCanUse

1. Which prophylaxis do you chose after a hip or knee surgery? Simplistic: ASA=LMWH Correct: ASA has similar mortality & PE as LMWH but 1-2% more uncomplicated DVTs In people at very high VTE risk, may consider LMWH if convenience & cost not an issue x.com/AnilMakam/status/16161…