Axonal mRNA trafficking and local translation | Group leader @FGA_lab | NWO Veni fellow | father of two
Joined July 2015
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Pinned Tweet
5 Sep 2024
So excited and grateful that @ERC_Research #ERCStG will fund my project RNA.ORG to investigate the molecular mechanisms that regulate mRNA localization in neurons! There will be positions opening soon so get in touch if you are interested! @FGA_lab @VUamsterdam
5 Sep 2024
📣 The latest ERC Starting Grant competition results are out! 📣
494 bright minds awarded €780 million to fund research ideas at the frontiers of science.
Find out who, where & why 👉 europa.eu/!hrxyBp
🇪🇺 #EUfunded #FrontierResearch #ERCStG @HorizonEU @EUScienceInnov
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3 Dec 2024
The next speaker on the stage is @MaxKoppers #celltransportconf
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16 Nov 2024
very cool paper!
FMRP regulates MFF translation to locally direct mitochondrial fission in neurons | Nature Cell Biology nature.com/articles/s41556-0…
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5 Nov 2024
RNA granules in flux: dynamics to balance physiology and pathology — a Review by Michael A. Kiebler & Karl E. Bauer
go.nature.com/3UCa0Se
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31 Oct 2024
Check out our preprint using imaging-omics to characterize the #OrganelleSignature - the morphology interactions & distribution of #ER❤️ #Lysosomes🩵 #Mitochondria💚 #Peroxisomes🧡 #Golgi💛 & #LipidDroplets🩷 - of live #neurons and #astrocytes!
doi.org/10.1101/2024.10.30.6…
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31 Oct 2024
APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2 instead of H2O2. We use LaccID for EM imaging of cultured cells and fly brains, and for proteomic mapping of the changing surface composition of T cells that engage with tumor cells via antigen-specific T cell receptors.
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29 Oct 2024
Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!)
O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵
nature.com/articles/s41592-0…
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29 Oct 2024
Spatiotemporal dynamics and selectivity of mRNA translation during mouse pre-implantation development biorxiv.org/content/10.1101/…
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24 Oct 2024
Neuromuscular dysfunction in patient-derived FUSR244RR-ALS iPSC model via axonal downregulation of neuromuscular junction proteins biorxiv.org/content/10.1101/…
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Light-induced targeting enables proteomics on endogenous condensates 🤯
cell.com/cell/fulltext/S0092…
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21 Oct 2024
IGF2BP1 phosphorylation in the disordered linkers regulates ribonucleoprotein condensate formation and RNA metabolism: nature.com/articles/s41467-0…
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17 Oct 2024
Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43 ribonucleoprotein condensates disrupting mRNA transport and local translation in neurons
cell.com/developmental-cell/…
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3 Oct 2024
Getting ready (rushing) for #SfN24?Us too!😃
Excited about Neuron, Glia, RNA, Plasticity, FXS or Local Translation?Us too!😃
Come join us Tues 8th, with 14 great (&short!) talks on emerging roles of axonal, dendritic, glial proteostasis in health & disease
pls spread the word!
ALT mRNA Regulation and Translation in Plasticity Tues 8th @ 8am - 11:30am MCP Room S404 Speakers: Eurus Wang (Lai lab), City Univ. of Hong Kong Jacque Ip, The Chinese Univ. of Hong Kong Ruth Singer (Darnell lab), The Rockefeller Univ. Dong-Woo Hwang (Singer lab), Albert Einstein Col. of Med. Hovy Wong (Sjöström lab), McGill Univ. Ernesto Griego (Castillo lab), Albert Einstein Col. of Med. Pabitra Sahoo, Rutgers Univ. Newark Ulrich Hengst, Columbia Univ. Jimena Baleriola, Achucarro Bacque Ctr. for Neurosci., Spain Nisha Raj, Emory Univ. Aurore Thomazeau, CNRS, France Jewel Li (Sossin lab), McGill Univ. Haiyan He, Georgetown Univ. Michael Vasek (Dougherty lab), Washington Univ. in St. Louis
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19 Sep 2024
We are hiring! If you are looking for a PhD position and are interested in cellular and molecular neuroscience, consider applying! @FGA_lab @VUamsterdam @ERC_Research Please share 🙏
workingat.vu.nl/vacancies/ph…
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13 Sep 2024
AXON2025 is gearing up! If you're passionate about neural circuit development, this is the must-attend event of next year — set in an extraordinary, non-conventional location🚢that you won’t want to miss! #AXON2025 @JeroenPasterk
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13 Sep 2024
bioRxiv: Cytoplasmic ribosomes hitchhike on mitochondria to dendrites dlvr.it/TDBq1d
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26 Jun 2024
Conference in Grenoble 3th and 4th December 2024 "Organelles Transport in Health and Disease" --> Registrations are now open!! cell-transport.sciencesconf.…
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hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis
rdcu.be/dSCZF
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27 Aug 2024
Excited to share our latest work on how the RNA binding protein HNRNPA2B1 regulates RNA abundance and motor protein activity in neurites! biorxiv.org/content/10.1101/…
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