🚀 Excited to share our latest research on metabolomic signatures of carfilzomib-related cardiotoxicity in multiple myeloma patients, highlighting our newly developed risk score! #CardioOncology #Research Our study investigates the endothelial dysfunction in patients undergoing carfilzomib treatment, focusing on creating a predictive risk score for cardiovascular adverse events (CVAE). #EndothelialDysfunction We found that lower levels of protective biomarker T-UDCA in patients who developed CVAE could indicate a predisposition to these adverse events. This finding was crucial in developing our risk score. #Biomarkers #CVAE By analyzing post-baseline/baseline ratios of metabolites, we identified key differences in dihydroxybenzoate, GCDCA, and ferulic acid between CVAE and non-CVAE patients. These metabolites are integral to our risk score. #Metabolomics Our risk score incorporates the levels of these metabolites, providing a quantifiable measure to predict the likelihood of CVAE in patients undergoing carfilzomib treatment. #RiskScore #PredictiveModeling Dihydroxybenzoate, known for its cardioprotective properties, plays a significant role in our risk score, linking metabolomic changes to potential cardiovascular risks. #Cardioprotection The risk score also considers the beneficial roles of T-UDCA, statins, and regular exercise in reducing CVAE, emphasizing the importance of preventive strategies in high-risk patients. #CardioHealth #PreventiveCare By integrating these factors, our risk score offers a personalized approach to predicting and mitigating cardiovascular risks, enhancing patient care and outcomes. #PersonalizedMedicine #CardioOncology Our research contributes to a better understanding of the mechanisms behind carfilzomib-related cardiotoxicity and provides a practical tool for clinicians to assess and manage these risks. #CancerTherapy #RiskAssessment 🔍 Dive into the full study for a comprehensive look at our methodology, detailed findings, and the development of our risk score: pubmed.ncbi.nlm.nih.gov/3878… #ResearchPublication #Science

if your parents worked hard to give you a safety net, don't insult them by playing it safe

Steve Sailer posted a cool new paper finding that boys who are old for their grade make more friends and become leaders. I checked it against Columbia admissions data: Kids who are youngest in their grade are measurably less likely to make it to Columbia.

🇺🇸 🇮🇷 If you’re keeping track at home: - Obama: $1.7B in unfrozen assets/cash for 98% reduction in uranium & limit enrichment to 3.7% - Trump: $24B in unfrozen assets/cash, $300B reconstruction fund, lifted sanctions in exchange for opened Strait under Iran/Oman control

I do not understand, in 2026, why anyone is shorting anything, and I have, over the last several years, watched a generation of intelligent, well-credentialed, technically sophisticated investors set fire to their capital on the short side of a market that has been telegraphing its direction with the subtlety of a marching band, and the only explanation I have ever been able to construct is that none of these people have read a single page of monetary history written before 1990. The setup is not subtle. The federal government is running a 7% structural deficit with no political coalition in either party willing to address it. The Treasury is issuing debt at a pace that will push publicly held debt-to-GDP past 130% within five years, which is the level at which, historically, every government in recorded history has either inflated its way out, defaulted, or both. The Fed is, regardless of what it says in public, the marginal buyer of that debt, and the only mechanism it has to fund the purchases is the creation of new dollars. The money is being printed. The debt is being monetized. The currency is being debased. And asset prices, which are denominated in the currency being debased, are doing the only thing they have ever done in any country that has ever tried this, which is going up. Every country that has run this experiment has produced the same chart. Weimar Germany in 1922 and 1923 produced one of the most violent equity bull markets in recorded history in nominal terms, as the mark collapsed and the Berlin exchange repriced upward by orders of magnitude. Argentina, across four separate inflationary cycles since 1975, produced in each cycle a nominal rally that outran every short thesis published, while the peso lost 99.9% of its purchasing power. Zimbabwe in 2007 and 2008 produced an equity market that rose so violently the exchange had to be closed because the calculations could not keep up. Turkey, right now, in front of the entire world, has produced a Borsa Istanbul up 1,400% in lira terms while the lira has lost 85% against the dollar, and every short of Turkish equities has been carried out in nominal terms even when they were right in real terms. The lesson is not that asset prices are going up because the businesses are getting better. The lesson is that asset prices are going up because the unit they are measured in is getting smaller, and any investor who positions short against this dynamic is betting against the will and capacity of a government to debase its own currency, which is the single most reliable bet you can lose in 4,000 years of recorded monetary history. The government always wins. The government always debases. The currency always loses purchasing power. The assets always reprice upward in nominal terms, on a path the shorts always insist is unsustainable and that always, somehow, sustains. You can short individual frauds. You cannot short the market. You cannot short the currency itself without being on the wrong side of the largest force in modern capital markets, which is the slow, politically inevitable destruction of the dollar’s purchasing power against everything that cannot be printed. The shorts have been wrong for five years. They will be wrong for the next five. The only investors who will, in real terms, preserve and grow their wealth are the ones who understood, early, that the game is not about being right on valuation, it is about being on the right side of monetary debasement, and the right side has always been owning real assets, productive businesses, scarce commodities, and the one monetary metal that has functioned as money continuously for 5,000 years, while the people on the other side continue to insist this time is different. This time has never been different. The math is the math. The shorts will continue to lose. The owners will continue to win.

It’s the emperors birthday, treaty signed with Persia, gladiatorial games done in front of the Capitol in celebration. Trump is Caesar Maxxing this weekend

Byron Donalds still won't debate. Why do you think he's avoiding the stage? 1️⃣ Doesn't know the issues 2️⃣ Doesn't want to defend his record 3️⃣ Doesn't want voters comparing candidates 4️⃣ All of the above

I'm still stunned by this. The largest group of voters in RPOF's own poll said they're undecided, and @FloridaGOP 's response is to say we don't need a debate. It's clear that Florida voters are looking for an alternative to Donalds and want to hear from the other candidates.

The chairman of the party should not be insulting the intelligence of Republican voters. A debate was promised and these ridiculous criteria are being used to renege on that promise and to engineer a preferred outcome. Why not just take 90 minutes, find a tv partner, and let the candidates mix it up? The only reason why you wouldn’t is if the party hierarchy is serving outside interests instead of the best interests of the voters.

Republicans are in charge because we promised: to Make America Healthy Again. to start No New Wars, to put people above corporations, to put America above foreign countries, to release the Epstein files, to not spy on citizens, to eliminate fraud, what the hell happened?!

🚨Governor DeSantis RIPS the @FloridaGOP to SHREDS for trying to RIG the election for Byron Donalds! Says they are BETRAYING voters by canceling the debate w their SHADY secret criteria! Says HE wouldn’t have won in 2018 if they rigged it this way! “Yeah, there should be a debate! They said they were going to do a debate. They didn't put out the criteria publicly. I don't think RPOF ever voted on any type of criteria. I've heard secondhand what the criteria was. I wouldn't have qualified when I ran in ‘18 for what they were trying to do! And so it's counterproductive when you try to engineer an outcome because you need a coalition of voters to do well. And this may be a tough cycle for Republicans if you look at some of the indicators, the way things are trending. And so having an open process and having people be able to have their say is always better than to try to engineer an outcome. So what the party should be doing is what's in the best interest of Republican voters. You shouldn't have another agenda. You shouldn't be answering to ANYONE ELSE (Susie Wiles) other than the voters there. Now, having said that, this whole notion that the party should control debates is ridiculous. You don't need the party to control it! They have NO AUTHORITY to control debates. We did a debate when I was running in 18. We did one on Fox News and had nothing to do with it. I mean, I think the party was involved in terms of like getting people to attend, but we did it. They put it on TV. And so you can do something like that, having nothing to do with the party. You know, the party has a very limited role. It should be a CANDIDATE-DRIVEN process and NOT for people to be making decisions who voters have never voted into those positions to begin with! So line up something with TV, line up something, radio, all these different forms. There's a whole host of ways that you can do, but to just set criteria, especially with polling when most people haven't started paying attention. Qualifying just ended today. So up until 11.59 this morning, you could have qualified to run in these races! So yeah, I think to do those types of criteria, I think ultimately is counterproductive. I think you alienate people for no reason. And look, we've had a great run in Florida, but part of it is, you know, we've really, I think respected the voters and worked really hard to build that trust and support that has seen us go from 300,000 more registered Democrats when I got elected in 18 to now 1.5 million more registered Republicans. I mean, I won this county in 2022, Palm Beach. First time in 40 years a Republican was able to do that. And Palm Beach used to have 170,000 gap between DNR. That gap is narrow dramatically to where you potentially could have Palm Beach have a plurality of Republican registrants. But I think that complicates it if people don't have confidence in the party label in the party brand.”

Florida Governor Ron DeSantis slammed the Florida GOP after the Sunshine State Showdown revoked gubernatorial candidate James Fishback’s debate invitation and announced that only Byron Donalds had qualified. DeSantis argued that, under similar standards, he would not have qualified for debates during his 2018 gubernatorial run, saying the party should not engineer outcomes or control the process from the top down. Follow: @AFpost

Tucker Carlson alleges that through bribes, assassination attempts, spying, and political pressure, Israel has forced Trump into war with Iran that he can’t get out of. Carlson has noted that Trump shut down his own investigation into the Butler Assassination Attempt, was terrified of Bibi Netanyahu giving him a golden pager, and that, despite his best efforts, Trump has been steadily slow-walked into a war with Iran against his will. Carlson has also alleged that Charlie Kirk, a chief opponent of war against Iran, was assassinated as part of a broader plot, with Israel covering it up, despite believing Tyler Robinson’s involvement. Carlson pointed to Joe Kent and numerous attempts made by Israel not only to spy on Trump, but to hinder “first responders” that would help Trump in an assassination attempt. Examining the war, Tucker points out that the US has spent more on defending Israel than on the Gulf states, and more defending Israel that it has spent on its own defense. Follow: @AFpost

Really neat: The huge uptick in early-onset colorectal cancer appears to be due to a classification change, rather than a real biological phenomenon.

> only 12.3% reached a level of “eminence,” defined as “full professors…Fortune 500 execx … judges, lawyers, leaders in biomedicine, award-winning writers.” This means 88% never did. GPT says this is 0.4% of adults So gifted 'only' achieve it at 31x the base rate.

Florida's population losses are compounding. Miami had the 4th-largest population loss among U.S. metros in Q1 2026. Orlando had the 6th biggest. And Tampa lost more people than Chicago. This data comes from Bank of America's internal account data and is a shocking revelation for anyone who thinks Florida's housing market is recovering. People continue to leave Florida due to still high prices, soaring property taxes, and expensive insurance. So much so that a state that was built on massive levels of in-migration of Americans is now losing people in its three biggest metro areas. As a result, don't be surprised if Florida's housing market continues to correct until things become cheap enough to keep people from leaving. Track migration by county at reventure.app/mobile.

Incomes not keeping pace with inflation has been the persistent economic issue for tens of millions of Americans for quite some time. When Congress borrows trillions and runs massive deficits, it is still an effective tax increase — it just comes in the form of higher prices.

The FDA just approved BEMT for sunscreens! That means sunscreen is about to get - More effective - Longer-lasting - Less absorptive - Better looking (no white cast!)

The psyop men fall for is, “You can have kids anytime.” While true, the other side of this coin is, “Every day you delay kids is a day you don’t get with your grandkids.”

I hope so

He has almost all of them.