We are a young Chemical Biology/RNA/Molecular Genetics lab at Yale Chemistry, working toward discovering the dark matter of the human genome.

Joined February 2020
Photos and videos
SlavoffLab retweeted
Seven Chemistry students were awarded #NSF fellowships for their graduate research, showing great promise for future advancements in chemistry. We’ve spotlighted them and their research in this article. Meet the Yale Chemistry NSF Fellows! bit.ly/46QSiRN
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30 Jun 2025
Hello RNA World! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @CellReports, @FKHM and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac
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SlavoffLab retweeted
Ever wondered why we need respiratory supercomplexes? New findings from our lab, in collaboration with @LettsScience, show how a specialized supercomplex - the SC-XL - can help mitochondria overcome some respiratory defects & provide cardioprotective benefits. Studying #Microproteins (i.e. Brawnin) led to this amazing discovery, a testament to the power of small! cell.com/cell-metabolism/ful…
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@Slavofflab will continue our track record of sporadic-at-best social media engagement at🦋🌈. See you ... occasionally!
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29 Oct 2024
Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 nature.com/articles/s41592-0…

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SlavoffLab retweeted
Check out our News&Views highlighting the work of @Keribackus in @nchembio : a new form of cellular stress and collateral degradation of proteins induced by electrophilic small molecule fragments. Work of @RosaCarolinae @KaylaENutsch rdcu.be/dXZpw

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SlavoffLab retweeted
Thrilled to share our new study in @nchembio describing the proteome-wide impacts of electrophile stress in the context of covalent fragments. Big congratulations to first authors Ashley Julio @AshleyJulio4 and Flowreen Shikwana @FShikwana ! 1/5 nature.com/articles/s41589-0…
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SlavoffLab retweeted
Led by the Yale Nanobiology Institute's Julien Berro, a team of scientists have received an #NIHHighRisk award to build a new sensor to target the mechanical properties of diseased cells bit.ly/berro-sensor @NIH_CommonFund
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SlavoffLab retweeted
9 Oct 2024
Not for the first time, all Nobel Prizes in scientific disciplines this year have been awarded to men
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SlavoffLab retweeted
Please RT: We have TWO postdoctoral positions available to study microProtein function in tomato. If you’re interested in working in an international team in a strong plant research center in a literally cool location. Please apply here: umu.se/en/work-with-us/open-…

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SlavoffLab retweeted
My first op-ed is out! Starting my faculty career was challenging in many ways, and one of those is that I had a leadership job that I didn't expect and wasn't (really) prepared for. Thanks to @insidehighered for the chance to write about this and share some advice!
Career Advice | A Leadership Position We Aren’t Prepared For Faculty members who run a lab have a research job and a leadership job, but they are often only trained for one of those, @WUSTL's Jen Heemstra writes. bit.ly/3T7fTGb
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SlavoffLab retweeted
Dear small protein/microprotein/sORF enthusiasts. I am currently editing the first methods book on microproteins. If you would like to contribute a chapter please get in touch! I would also appreciate if you could share this information in your network.
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SlavoffLab retweeted
We’re hiring a tenure-track professor (any level) to teach courses and develop research programs in experimental physical, theoretical, or organic chemistry, starting 8/1/25. Apply by 9/30/24 to be considered for the first round of interviews. apply.interfolio.com/150561

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SlavoffLab retweeted
Our lab’s first @chemcomm! We find that amidine-capped cysteine residues can be cleaved by trypsin to improve detection of tough-to-ID cys (e.g. resis found in very long sequences lacking K/R). Congrats to first author @SamioOfori and team! pubs.rsc.org/en/content/arti…
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SlavoffLab retweeted
If you have a leadership job, then you also have a kindness job. Yes, there is work to get done and goals to meet. But we also have a responsibility to leverage our authority and decision making capability to uphold human dignity.
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SlavoffLab retweeted
How do intrinsically disordered regions (IDRs) regulate protein function? Today in @MolecularCell, we show how the IDR of LSD1 acts as a fuzzy molecular switch to tune transcription factor interactions & control leukemia differentiation. (1/6) sciencedirect.com/science/ar…

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SlavoffLab retweeted
Do you: A) Love chemical biology? B) Live in Europe or want to visit Germany? If you answered yes to either, why are you not yet already signed up for this year's EMBO Chemical Biology workshop, taking place Sept 9-12 in Heidelberg? embl.org/about/info/course-a…
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SlavoffLab retweeted
Then and now, 101 yrs later, we celebrate the science and community at the Sterling Chemistry Laboratory. Thank you alumni, department members, and friends for participating in the Sterling Chemistry Laboratory 101st Anniversary Celebration & Alumni Connect! Photo: John Dempsey
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SlavoffLab retweeted
Alumni, you’re invited back to the Sterling Chemistry Lab to celebrate its centenary on May 10. Historical and research talks, facilities tours, student posters, dinner, and more. Optional activities: 5/9 & 11. See program, register, and book your hotel at bit.ly/SCLcelebrate
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SlavoffLab retweeted
Very excited to team up with @LupoliLab @nyuniversity @nyuchemistry in organizing the End of Year Chemical Biology Symposium, which will take place 6/6 @WeillCornell! Plenty short talks and poster presentations available for our NYC Chem Bio community! events.nyas.org/event/bc29f8…

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